Navigation Links
A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers
Date:7/31/2014

and so this remained as the critical unsolved piece of the puzzle. The new study completes the picture, by revealing which signaling molecules act as the Turing system" says James Sharpe, co-author of the study.

The approach taken was that of systems biology combining experimental work with computational modelling. In this way, the two equal-first authors of the paper were able to iterate between the empirical and the theoretical: the lab-work of Jelena Raspopovic providing experimental data for the model, and the computer simulations of Luciano Marcon making predictions to be tested back in the lab.

By screening for the expression of many different genes, they found that two signalling pathways stood out as having the required activity patterns: BMPs and WNTs. They gradually constructed the minimal possible mathematical model compatible with all the data, and found that the two signalling pathways were linked through a non-diffusible molecule the transcription factor Sox9. Finally, they were able to make computational predictions about the effects of inhibiting these 2 pathways either individually, or in combination which predicted how the pattern of fingers should change. Strikingly, when the same experiments were done on small pieces of limb bud tissue cultured in a petri dish the same alterations in embryonic finger pattern were observed, confirming the computational prediction.

This result answers a long-standing question in the field, but it has consequences that go beyond the development of fingers. It addresses a more general debate about how the millions of cells in our bodies are able to dynamically arrange themselves into the correct 3D structures, for example in our kidneys, hearts and other organs. It challenges the dominance of an important traditional idea called positional information, proposed by Lewis Wolpert which states that cells know what to do because they all receive information about their "coordinates" in s
'/>"/>

Contact: Juan Manuel Sarasua
juan.sarasua@crg.eu
34-934-160-159
Center for Genomic Regulation
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Penn research helps lay out theory for metamaterials that act as an analog computer
2. Surprise: Viruses Can Cause Disease during Latent Phase; New Evidence Supports Microcompetition Theory
3. Enteroviruses Cause Type 1 Diabetes; New Studies Support Dr. Hanan Polansky’s Microcompetition Theory
4. Surprise: Flu Vaccine Prevents Heart Attacks and Strokes; New Study on Flu Vaccine Supports Dr. Hanan Polansky’s Microcompetition Theory
5. Scientific Proceedings Published, Challenging Conventional Neo-Darwinian Theory
6. Orlando Holistic Medicine and Wellness Center Releases Conspiracy Theory Thriller Book
7. 31st International Symposium on Lattice Field Theory
8. Major grant to investigate limits of quantum theory
9. Maths experts question key ecological theory
10. Rice professors nanotube theory confirmed
11. Microlin Bio Files Registration Statement for $25,000,000 Proposed Initial Public Offering
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... Horovitz , Ph.D., from its board of directors effective on ... August 2003, and served as its chairman from June 2006 ... the Nominating and Corporate Governance and Audit Committees of the ... than a decade of dedicated service to GenVec, and its ...
(Date:10/19/2014)... The Latin American hardware encryption display market ... with analysis and forecast of revenue. This market was ... to reach $2,366.8 million by 2018, at a CAGR ... the TOC of the Latin American hardware encryption market ... provided. It also provides a glimpse of the segmentation ...
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report defines and ... and forecast of revenue. This market is estimated to ... by 2019, at a Compound Annual Growth Rate (CAGR) ... the TOC of the Asia-Pacific Speech Analytics market report ... It also provides a glimpse of the segmentation in ...
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, ... Human Insulin (Rapid Acting, Long Acting, Premixed)], by ... - Forecast to 2018” provides a detailed overview ... market trends, and strategies impacting the global human ... of the revenue and share analysis. , The ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5
... Informex , the leading meeting place for buyers ... the Global Pharma Sourcing Conference to be held December ... Philadelphia, Pennsylvania. The two day program will be jointly ... address key issues that global chemical and pharmaceutical industry ...
... Corp. (IDC), a privately held biotechnology company developing ... and allergy, announced today that it has entered ... investigate the use of IDC,s Glucopyranosyl Lipid Adjuvant ... in the field of allergy. (Logo: ...
... Inc. (Nasdaq: SGMO ) today reported third quarter ... third quarter ended September 30, 2011, Sangamo reported a consolidated ... to a net loss of $8.7 million, or $0.19 per ... 30, 2011, the Company had cash, cash equivalents and marketable ...
Cached Biology Technology:Informex Introduces a Thorough Global Pharma Perspectives Conference 2Sangamo BioSciences Reports Third Quarter 2011 Financial Results 2Sangamo BioSciences Reports Third Quarter 2011 Financial Results 3Sangamo BioSciences Reports Third Quarter 2011 Financial Results 4Sangamo BioSciences Reports Third Quarter 2011 Financial Results 5Sangamo BioSciences Reports Third Quarter 2011 Financial Results 6
(Date:10/18/2014)... patients referred for evaluation of suspected genetic conditions, ... 25 percent, including detection of a number of ... disease, according to a study appearing in ... coincide with the American Society of Human Genetics ... or coding regions of thousands of genes simultaneously ...
(Date:10/17/2014)... Researchers from the University of Copenhagen have shown for ... the lungs of Cystic fibrosis patients, giving them the ... growth in chronic infections. , The study also discovered ... fibrosis (CF) patients was halted or slowed down by ... consumed all the oxygen and helped "suffocate" the bacteria, ...
(Date:10/16/2014)... Oregon and Washington land managers have a new synthesis ... eastside moist mixed-conifer (MMC) forests in the two states. ... Forests in Eastern Oregon and Washington: A Synthesis of ... Management, a general technical report published by the U.S. ... response to a request from managers for a synthesis ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2
... at the Smithsonian and partnering organizations have discovered a remarkably ... the Republic of Palau. This fish exhibits many primitive anatomical ... 800 species of living eels, resulting in its classification as ... The team,s research is published online in the Proceedings ...
... Sons of male mice exposed to prenatal stress are ... in the August 17 issue of The Journal of ... lead to individual differences in stress response that may be ... of Pennsylvania, and colleagues previously found that male mice were ...
... and Switzerland have investigated the remarkable distance that microorganisms ... about their potential to colonise new lands and also ... John Moores University (LJMU), Swiss Federal Institute for Forest, ... Fdrale de Lausanne (EPFL) the University of Neuchtel published ...
Cached Biology News:Scientists discover the most primitive living eel 2Effects of prenatal stress passed across generations in mice 2Life on the wind: Study reveals how microbes travel the Earth 2
Although each Beacon 2000 System includes one preinstalled sample chamber (size specified at time of order), optional chambers are available and easily retrofit by the user....
Whole blood is collected from healthy guinea pigs of either sex from US source which are free of visible diseases at time of blood collection. Hemolytic titer: CH50 = 435 units...
...
... serial preparation of four ... cytosol/particulate/cytoskeleton/nuclear fractions from one ... can directly be used ... as 2-D gel/Western blot/gel-shift/translocation/enzyme ...
Biology Products: