Navigation Links
2 problems in chemical catalysis solved
Date:12/20/2012

The research group of Professor Petri Pihko at the Department of Chemistry and the NanoScience Center of the University of Jyvskyl has solved two acute problems in chemical catalysis. The research has been funded by the Academy of Finland.

In the first project, the researchers designed a novel intramolecularly assisted catalyst for the synthesis of beta amino acids. Previously published catalysts work only with aromatic side chains in the imines, but the new catalyst designed at Jyvskyl does not have this limitation. The new method might find uses in the synthesis of beta amino acids, which are important building blocks for chemical biology. For the understanding of the catalytic mechanism and design of the catalyst, the researchers collaborated with the group of Imre Ppai (Hungarian Academy of Sciences, computational studies) and Academy Professor Kari Rissanen (Jyvskyl, X-ray characterisation of catalysts).

In the second project, the researchers identified a completely new mechanism for the amine-catalysed Michael addition reaction between aldehydes and nitroalkenes. The mechanism has been a source of intense discussion within the scientific community, with the groups of Professor Yujiro Hayashi (Tokyo), Professor Donna Blackmond (La Jolla, USA) and Professor Dieter Seebach (ETH, Switzerland) each presenting different possible mechanisms.

The new model proposed by the Pihko and Papai groups includes a new species, a six-membered ring, as the key on-cycle intermediate that is protonated in the rate-determining step. The work is a combination of computational and experimental studies that complement each other in understanding the mechanism and demonstrate how difficult mechanistic puzzles can be solved by joining the forces of both approaches.


'/>"/>

Contact: Petri Pihko
petri.pihko@jyu.fi
358-505-289-132
Academy of Finland
Source:Eurekalert  

Page: 1

Related biology technology :

1. Cold Adds Up to Sandy Victims' Mold Problems; Optimal Chemical Reaches Out to Help by Advising the Use of Molderizer
2. Entrepreneurs to Eat Problems for Breakfast in San Diego
3. A thin-skinned catalyst for chemical reactions
4. 20% Off Your Entire Order of Scientific, Technical, Medical (STM) Titles Until the End of December at Chemical Publishing Company
5. Chemical Publishing Company Announces its Niche Catalog in the Water Technology and Water Treatment Space
6. Piedmont Chemical Launches 100 Percent Renewable Polyester Polyols Leveraging Renewable Chemicals from DuPont Tate & Lyle Bio Products and Myriant Corporation
7. Researchers improve technology to detect hazardous chemicals
8. From lectures to explosives detection: Laser pointer identifies dangerous chemicals in real-time
9. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
10. ESTEVE Announces the Publication of Comprehensive Phase I Data for a Novel Oral, First-in-class New Chemical Entity (NCE),E-52862, a Sigma-1 Receptor Antagonist (S1RA) Being Developed for Pain
11. Chemical makes blind mice see; compound holds promise for treating humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 problems in chemical catalysis solved
(Date:11/18/2014)... , Nov. 18, 2014 PDL BioPharma, ... that in connection with the acquisition of Durata Therapeutics, ... in connection with the termination of PDL,s credit agreement ... amount outstanding of $40 million, accrued interest, and prepayment ... entered into a structured financing transaction with Durata in ...
(Date:11/17/2014)... The new METTLER TOLEDO White Paper " Traceability ... becoming the first calibration laboratory in the world ... the microgram range. National Metrology Institutes (NMI's), private ... in nanotechnology applications will benefit from understanding the ... weights in the range of 0.05 mg to ...
(Date:11/15/2014)... Burlington, MA (PRWEB) November 13, 2014 ... today announced they were named one of the Boston ... among the Medium Sized Businesses in Massachusetts to receive ... Work’ honors employers who take care of their most ... The awards are presented annually, and are based on ...
(Date:11/15/2014)... Denver, Colorado (PRWEB) November 14, 2014 ... leading provider of proprietary, cloud-based analytics, and scientific ... results for the third quarter ended September 30, ... Quarter 2014 Highlights, ,     CannLabs – ... in Las Vegas, Nevada. ,     CannLabs – ...
Breaking Biology Technology:PDL BioPharma Announces Successful Conclusion of Debt Financing Agreement with Durata Therapeutics 2New White Paper on Microgram Weights Describes How to Achieve Traceable Measurement Down to 0.05 Milligrams 2Collaborative Consulting Honored with Boston Globe Top Places to Work 2014 2CannLabs Announces Third Quarter 2014 Results. 2CannLabs Announces Third Quarter 2014 Results. 3CannLabs Announces Third Quarter 2014 Results. 4CannLabs Announces Third Quarter 2014 Results. 5
... ... expanding its Research Triangle Operations. Scott Garrison is named a new partner. ... Research Triangle Park, ... and leading provider of outsourced CFO-level financial and management services for technology and biotechnology ...
... ... Improve Precision and Reduce Risk of False Positives/Negatives , ... Rochester, New York (PRWEB) January 8, 2010 -- ... announced today that a leading global CRO has selected iCardiac as a preferred vendor ...
... , , , , ... China,Yongxin Pharmaceuticals, Inc. (OTC Bulletin Board: CYXN; "China Yongxin,Pharmaceuticals" ... of Chinese traditional medicines, pharmaceutical products, natural,health products, health ... Company today announced that it had opened three new ...
Cached Biology Technology:TechCFO Continues Research Triangle Park Expansion; Garrison Named New Partner 2Leading Global CRO Selects iCardiac as Preferred Vendor 2China Yongxin Pharmaceuticals Opened Three New Stores in 2009 and Expanded Customer Base 2China Yongxin Pharmaceuticals Opened Three New Stores in 2009 and Expanded Customer Base 3
(Date:11/3/2014)... study published in this month,s Proceedings of ... of a recently discovered communication molecule of the body,s ... known to limit inflammation and the current study reports ... the ability of the immune system to recognize and ... IL-37,s effect on the immune system now allows us ...
(Date:11/2/2014)... (2 November 2014)—In support of a bold quest to ... Melinda Gates Foundation today announced an award of US$156 ... Initiative (MVI) in building new vaccines that will interrupt ... the "accelerating to zero" agenda. Such vaccines would ensure ... be called an "immunological bed net." , This ...
(Date:10/31/2014)... 1900s, Brazil was the world,s largest producer of cocoa. ... a 800, 000 ha region of rainforest in the ... shade trees. Whereas the surrounding rainforest was a biodiversity ... a handful of seeds introduced in the mid 1700s, ... Brazilian scientist Gonçalo Pereira, "This scenario created a very ...
Breaking Biology News(10 mins):PNAS: From HIV to cancer, IL-37 regulates immune system 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4Scientists seek cure for devastating witches' broom disease of the chocolate tree 2Scientists seek cure for devastating witches' broom disease of the chocolate tree 3
... not only uncomfortable, it can be deadlycausing proteins to ... scientists have understood the molecular mechanisms that enable animals ... that directly trigger heat sensor proteins known as TRP ... animals sense very small temperature differences in the comfortable ...
... and induced pluripotent stem cell technology are among ... through The Michael J. Fox Foundation,s Rapid Response ... to drive transformative treatments and a cure for ... 15 high-risk, high-reward Parkinson,s disease research projects under ...
... atmosphere, and from the human use of fossil fuels, the ... life support system. The chemical balance of the sea has ... pH of the sea,s surface water has gone down by ... just over a century ago. Jon Havenhand and Michael Thorndyke, ...
Cached Biology News:Summer heat too hot for you? What is comfortable? 2Summer heat too hot for you? What is comfortable? 3Michael J. Fox Foundation Funds $1.1 Million for Cutting-edge Approaches to Parkinson's Disease 2Michael J. Fox Foundation Funds $1.1 Million for Cutting-edge Approaches to Parkinson's Disease 3Acidification of the sea hampers reproduction of marine species 2
... negatively supercoiled DNA in presence of EDTA ... of supercoiling on transcription in vitro , ... the degree of supercoiling of naturally occurring DNA ... length by only one base-pair , Increasing ...
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
... Deletion Kit for Kilo-Sequencing is designed to ... cloned into the multiple cloning sites (MCS) ... plasmid or phagemid vectors (pUC18/19). The kit ... in the target DNA, thereby progressively moving ...
Applications: Immunohistochemistry, ISH, FISH, CISH....
Biology Products: