Navigation Links
2 problems in chemical catalysis solved
Date:12/20/2012

The research group of Professor Petri Pihko at the Department of Chemistry and the NanoScience Center of the University of Jyvskyl has solved two acute problems in chemical catalysis. The research has been funded by the Academy of Finland.

In the first project, the researchers designed a novel intramolecularly assisted catalyst for the synthesis of beta amino acids. Previously published catalysts work only with aromatic side chains in the imines, but the new catalyst designed at Jyvskyl does not have this limitation. The new method might find uses in the synthesis of beta amino acids, which are important building blocks for chemical biology. For the understanding of the catalytic mechanism and design of the catalyst, the researchers collaborated with the group of Imre Ppai (Hungarian Academy of Sciences, computational studies) and Academy Professor Kari Rissanen (Jyvskyl, X-ray characterisation of catalysts).

In the second project, the researchers identified a completely new mechanism for the amine-catalysed Michael addition reaction between aldehydes and nitroalkenes. The mechanism has been a source of intense discussion within the scientific community, with the groups of Professor Yujiro Hayashi (Tokyo), Professor Donna Blackmond (La Jolla, USA) and Professor Dieter Seebach (ETH, Switzerland) each presenting different possible mechanisms.

The new model proposed by the Pihko and Papai groups includes a new species, a six-membered ring, as the key on-cycle intermediate that is protonated in the rate-determining step. The work is a combination of computational and experimental studies that complement each other in understanding the mechanism and demonstrate how difficult mechanistic puzzles can be solved by joining the forces of both approaches.


'/>"/>

Contact: Petri Pihko
petri.pihko@jyu.fi
358-505-289-132
Academy of Finland
Source:Eurekalert  

Page: 1

Related biology technology :

1. Cold Adds Up to Sandy Victims' Mold Problems; Optimal Chemical Reaches Out to Help by Advising the Use of Molderizer
2. Entrepreneurs to Eat Problems for Breakfast in San Diego
3. A thin-skinned catalyst for chemical reactions
4. 20% Off Your Entire Order of Scientific, Technical, Medical (STM) Titles Until the End of December at Chemical Publishing Company
5. Chemical Publishing Company Announces its Niche Catalog in the Water Technology and Water Treatment Space
6. Piedmont Chemical Launches 100 Percent Renewable Polyester Polyols Leveraging Renewable Chemicals from DuPont Tate & Lyle Bio Products and Myriant Corporation
7. Researchers improve technology to detect hazardous chemicals
8. From lectures to explosives detection: Laser pointer identifies dangerous chemicals in real-time
9. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
10. ESTEVE Announces the Publication of Comprehensive Phase I Data for a Novel Oral, First-in-class New Chemical Entity (NCE),E-52862, a Sigma-1 Receptor Antagonist (S1RA) Being Developed for Pain
11. Chemical makes blind mice see; compound holds promise for treating humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 problems in chemical catalysis solved
(Date:9/2/2014)... NEW PROVIDENCE, N.J. , Sept. 2, ... a corporate sponsor for MassBio,s 20th Annual Golf Classic, ... MassBioEd Foundation. The event will be held on September ... Plymouth, Massachusetts . The ... Massachusetts through educational programs, workforce development, ...
(Date:9/2/2014)... Press attending the Project LIBERTY Grand Opening have ... people and events in Emmetsburg on Sept. 3. The ... day. Additionally, we will do our best to help ... well as representatives from the local community. Any advance ... remember to RSVP to Matt Merritt (matt.merritt@poetdsm.com) to receive ...
(Date:9/2/2014)... Opertech Bio, Inc., a company that ... approach to sensory evaluation, today announced the issuance ... Patent and Trademark Office, encompassing high-throughput sensory discrimination ... taste evaluation technology called Microtiter Operant Gustometer or ... for rapid characterization of taste sensory properties,” said ...
(Date:9/2/2014)... 2, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... orders consist of three large odour control systems for waste ... "These orders are consistent with the market resurgence in ... , President and CEO. "After a difficult period of restraint ... beginning to see sales growth. Our lower cost structure, technology ...
Breaking Biology Technology:Linde helps fund STEM education in Massachusetts 2Linde helps fund STEM education in Massachusetts 3Press agenda for Project LIBERTY Grand Opening 2Press agenda for Project LIBERTY Grand Opening 3Press agenda for Project LIBERTY Grand Opening 4Press agenda for Project LIBERTY Grand Opening 5Opertech Bio Receives U.S. Patent for High-Throughput Taste Evaluation Technology 2
... Third Wave Technologies is appointing more new ... to a press release. , ,Maneesh Arora, 37, will become ... has held senior positions in marketing and operations for the ... 35, will be vice president of finance. , ,John Bellano, ...
... investments in 2005 added up to more than $19 million ... report released on Wednesday. , ,The investor tax credits offered ... start to officially track the volume of investments by individuals. ... picture we've had of what's going on in the individual ...
... of financing is vital to a biotech company (it is ... "biotech" in the broadest sense) companies are continually faced with ... development cycle, this week's article will focus on venture capital ... on VC financing results from Burrill and Company's data. Burrill's ...
Cached Biology Technology:State tracks more angel investment, at least $19M last year 2U.S. VC funding flat in 2005 while life science funding grows 2U.S. VC funding flat in 2005 while life science funding grows 3U.S. VC funding flat in 2005 while life science funding grows 4
(Date:9/1/2014)... in the U.S. undergoes a battery of tests designed ... disease. Thousands of children born in the developing world, ... from the disease each year. , A.J. Kumar ... of those deaths. , A Post-Doctoral Fellow in ... George Whitesides, the Woodford L. and Ann A. Flowers ...
(Date:9/1/2014)... nucleotidethe basic building block of DNAcould initiate fragile X syndrome, the ... The Journal of Cell Biology . ... gene on the X chromosome called fragile X mental retardation ... 360 men carry a so-called premutation, in which a series of ... is slightly longer than normal. These repeats are prone to even ...
(Date:9/1/2014)... As nocturnal animals, bats are perfectly adapted to a life ... between the reflected echoes to measure distance to obstacles or ... different echo delays. A study carried out by researchers at ... that this map dynamically adapts to external factors. , ... bat flies in too close to an object, the number ...
Breaking Biology News(10 mins):Faster, cheaper tests for sickle cell 2Faster, cheaper tests for sickle cell 3A nucleotide change could initiate fragile X syndrome 2Zooming in for a safe flight 2
... are labeled a “night owl?report more pathological symptoms related ... for their nocturnal sleeplessness by extending their time in ... time, according to a study published in the April ... (JCSM). , The study, authored by Jason C. Ong, ...
... Southwestern Medical Center have found a new method for ... the most common acute infections in children. , ... by tracking down the virus or bacteria causing it. ... virus may not be present in the blood or ...
... Institutes of Health have discovered how a defect in ... several genes interact to create myelin, a fatty coating ... reliability of their electrical signals. , The discovery ... These disorders can affect the peripheral nervous system—the nerves ...
Cached Biology News:'Night owls' report more insomnia-related symptoms 2Infection detectives use disease 'fingerprints' to track common infections in children 2Infection detectives use disease 'fingerprints' to track common infections in children 3Researchers discover gene crucial for nerve cell insulation 2Researchers discover gene crucial for nerve cell insulation 3
UGT1A6 (D-20)...
... the Lone Wolf valve has the highest ... valve available on the market. This VSO ... performance, and ensures maximum accuracy., Achieves ... control and patient comfort. , Maintains ideal ...
Normal Hamster Serum...
...
Biology Products: