Navigation Links
2 problems in chemical catalysis solved
Date:12/20/2012

The research group of Professor Petri Pihko at the Department of Chemistry and the NanoScience Center of the University of Jyvskyl has solved two acute problems in chemical catalysis. The research has been funded by the Academy of Finland.

In the first project, the researchers designed a novel intramolecularly assisted catalyst for the synthesis of beta amino acids. Previously published catalysts work only with aromatic side chains in the imines, but the new catalyst designed at Jyvskyl does not have this limitation. The new method might find uses in the synthesis of beta amino acids, which are important building blocks for chemical biology. For the understanding of the catalytic mechanism and design of the catalyst, the researchers collaborated with the group of Imre Ppai (Hungarian Academy of Sciences, computational studies) and Academy Professor Kari Rissanen (Jyvskyl, X-ray characterisation of catalysts).

In the second project, the researchers identified a completely new mechanism for the amine-catalysed Michael addition reaction between aldehydes and nitroalkenes. The mechanism has been a source of intense discussion within the scientific community, with the groups of Professor Yujiro Hayashi (Tokyo), Professor Donna Blackmond (La Jolla, USA) and Professor Dieter Seebach (ETH, Switzerland) each presenting different possible mechanisms.

The new model proposed by the Pihko and Papai groups includes a new species, a six-membered ring, as the key on-cycle intermediate that is protonated in the rate-determining step. The work is a combination of computational and experimental studies that complement each other in understanding the mechanism and demonstrate how difficult mechanistic puzzles can be solved by joining the forces of both approaches.


'/>"/>

Contact: Petri Pihko
petri.pihko@jyu.fi
358-505-289-132
Academy of Finland
Source:Eurekalert  

Page: 1

Related biology technology :

1. Cold Adds Up to Sandy Victims' Mold Problems; Optimal Chemical Reaches Out to Help by Advising the Use of Molderizer
2. Entrepreneurs to Eat Problems for Breakfast in San Diego
3. A thin-skinned catalyst for chemical reactions
4. 20% Off Your Entire Order of Scientific, Technical, Medical (STM) Titles Until the End of December at Chemical Publishing Company
5. Chemical Publishing Company Announces its Niche Catalog in the Water Technology and Water Treatment Space
6. Piedmont Chemical Launches 100 Percent Renewable Polyester Polyols Leveraging Renewable Chemicals from DuPont Tate & Lyle Bio Products and Myriant Corporation
7. Researchers improve technology to detect hazardous chemicals
8. From lectures to explosives detection: Laser pointer identifies dangerous chemicals in real-time
9. Human brains share a consistent genetic blueprint and possess enormous biochemical complexity
10. ESTEVE Announces the Publication of Comprehensive Phase I Data for a Novel Oral, First-in-class New Chemical Entity (NCE),E-52862, a Sigma-1 Receptor Antagonist (S1RA) Being Developed for Pain
11. Chemical makes blind mice see; compound holds promise for treating humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 problems in chemical catalysis solved
(Date:9/17/2014)... September 17, 2014 Beckman Coulter ... science and healthcare, has renewed its agreement with ... part of the agreement, Personify will continue to streamline ... emphasis on recruitment analytics, including time-to-fill, time-to-source and a ... our agreement with Personify was based on the success ...
(Date:9/17/2014)... NASA’s MESSENGER has just celebrated its 10 year ... have one of its latch valves, V27200-818, operating onboard ... investigation of the planet Mercury. It is only the ... provided a vast amount of information and images of ... utilize solenoids that also include permanent magnets to maintain ...
(Date:9/16/2014)... BELLINGHAM, Washington, USA (PRWEB) September 16, 2014 ... how to create the features that we desire in ... Technology Center at Montana State University. “As we explore ... , Some of those lessons were presented in San ... Nature of Light: Light in Nature ” chaired by ...
(Date:9/16/2014)...  Biocom, the association representing the Southern ... th Annual National Health Information Technology Week, which ... improving our health care system. " ... world,s most vibrant hubs for health IT and digital ... genomic testing to remote patient monitoring," said Joe ...
Breaking Biology Technology:Beckman Coulter Signs 3-year RPO Contract with Personify 2Beckman Coulter Signs 3-year RPO Contract with Personify 3Nature’s designs inspire research into new light-based technologies 2Nature’s designs inspire research into new light-based technologies 3Nature’s designs inspire research into new light-based technologies 4Nature’s designs inspire research into new light-based technologies 5Biocom Recognizes National Health IT Week 2
... Nektar Therapeutics,(Nasdaq: NKTR ) will announce ... December 31, 2008 on Wednesday, February 25, 2009, after ... and chief executive,officer, will host a conference call to ... p.m. Pacific Time (PT). , ...
... Feb. 11 XTL,Biopharmaceuticals Ltd. (Nasdaq: XTLB ... Mr. Boaz Shweiger have been appointed to XTL,s Board ... also be assuming,the role of Co-Chief Executive Officer, with ... alternatives. , Ron Bentsur, Co-Chief ...
... ARLINGTON, Va., Feb. 11 Scientists engaged in biological ... in their 2009 lab budgets. BioInformatics, LLC ( ... the life science market, has released preliminary data from ... Down Market: Strategies for Life Science Suppliers. In ...
Cached Biology Technology:Nektar to Announce Year-End 2008 Financial Results on Wednesday, February 25, 2009 After Close of U.S.-Based Financial Markets 2XTL Biopharmaceuticals Announces Appointment of David Grossman and Boaz Shweiger to Board of Directors 2XTL Biopharmaceuticals Announces Appointment of David Grossman and Boaz Shweiger to Board of Directors 3Life Science Labs Reacting to the Economic Crisis 2
(Date:9/17/2014)... PROVIDENCE, R.I. [Brown University] After decades of decline, ... Cod,s saltmarshes. To the eye, the marsh in those ... clear that a key service of the marsh ... aesthetics back but the ecosystem function hasn,t come back," ... and senior author of the study in the journal ...
(Date:9/17/2014)... KNOXVILLEScience has learned a great deal about complex social ... might have something to teach too. , With their ... advanced cognition, parrots live in a complex social environment---not ... as bees or ants, but in a dynamic setting ... the most intelligent mammals: dolphins, whales, primates, and social ...
(Date:9/16/2014)... women in Australia is increased by lower socioeconomic ... September) in BJOG: An International Journal of ... high standards of living; however, existing research has ... indigenous and non indigenous Australians. , This case-control ... socioeconomic position on severe maternal morbidities associated with ...
Breaking Biology News(10 mins):Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3Being social: Learning from the behavior of birds 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 3
... sediments laid down shortly after an asteroid plowed into the ... is linked to widespread global extinctions including the demise of ... first fauna to show themselves following the global catastrophe. ... is often on the survival and proliferation of mammals, paleo-botanical ...
... The Dow Chemical Company has awarded UC Santa ... research initiative that will help shape the future of ... Materials Institute at UCSB will educate future scientists and ... with applications that range from novel polymers to next-generation ...
... Assigning environment-related legal cases to specialized tribunals, courts ... experts convene in Malaysia for a two-day United Nations ... and governance systems and sustainable development. High court ... country,s Supreme Court to ensure judges have the expertise ...
Cached Biology News:Worms among first animals to surface after K-T extinction event, CU-led study finds 2Worms among first animals to surface after K-T extinction event, CU-led study finds 3UCSB awarded $15 million by Dow to establish collaborative institute for materials research and education 2UCSB awarded $15 million by Dow to establish collaborative institute for materials research and education 3Specialized courts for environment cases among proposals as law experts mull green governance 2Specialized courts for environment cases among proposals as law experts mull green governance 3Specialized courts for environment cases among proposals as law experts mull green governance 4Specialized courts for environment cases among proposals as law experts mull green governance 5
...
... Immulon 2HB ELISA strips, ... increased binding affinity for hydrophilic proteins ... works well for reagent injection while ... Each strip accomodates 12 ...
...
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
Biology Products: