Navigation Links
UC Santa Barbara scientists learn how to unlock the destiny of a cell: A gift for the tin man?
Date:11/1/2012

(Santa Barbara, Calif.) Scientists have discovered that breaking a biological signaling system in an embryo allows them to change the destiny of a cell. The findings could lead to new ways of making replacement organs.

The discovery was made in the laboratory of Joel H. Rothman, a professor in the Department of Molecular, Cellular, and Developmental Biology at UC Santa Barbara. The studies were reported in the interdisciplinary journal Genes and Development, and were carried out by Ph.D student Nareg Djabrayan, in collaboration with Rothman and two other members of the laboratory, Ph.D student Erica Sommermann and postdoctoral fellow Nathaniel Dudley.

"At some point along the way toward becoming part of a complete individual, cells become destined to choose a particular identity and long-term profession," Rothman noted. "Once a cell chooses who it will be, it locks onto that identity for the remainder of its life."

A cell that is destined to become a heart cell functions exclusively in the heart until it dies, and never chooses later to change jobs by becoming, for example, a brain cell. "If Oz's wizard possessed the powers he claimed, and had a spare brain lying around, he could switch it to a heart as a gift for the Tin Man. And he could reverse the trick for the Scarecrow," Rothman said.

Similarly, the researchers have found a way to unlock cells' destinies and lead them to take on a new profession.

The scientists found that a widely used cell signaling system, known as "Notch" signaling, causes cells to commit to a particular occupation, such as a skin or brain cell. When they blocked the signal by genetic manipulation, the researchers discovered that they could force a cell to change its destiny, such that they instead became cells of the intestine.

"We found that we could break the signal in such a way that cells would follow their usual destinies, but were somehow less committed to doing so:
'/>"/>

Contact: George Foulsham
george.foulsham@ia.ucsb.edu
805-893-3071
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. inVentiv Health Selected to Provide Sales Operations Support for Santarus
2. Oracle chairman Jeff Henley makes $50 million gift to UC Santa Barbara
3. Kitware Announces Opening of Santa Fe Office
4. Scientists defuse the Vietnam time bomb
5. Singapore scientists lead human embryonic stem cell study
6. Sheffield scientists shine a light on the detection of bacterial infection
7. Nanowiggles: Scientists discover graphene nanomaterials with tunable functionality in electronics
8. Scientists solve mystery of colorful armchair nanotubes
9. iBioSeminars and iBioMagazine: Free, Online Biology Seminars and Short Talks by Leading Scientists
10. Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research
11. Scientists decode brain waves to eavesdrop on what we hear
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
 UC Santa Barbara scientists learn how to unlock the destiny of a cell: A gift for the tin man?
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... ... ... ... by longUrl, so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... tools inspired by video games are revealing how the ... human and animal research. Taking advantage of state-of-the art ... show with new detail how the brain navigates, identifies, ... apply these same technological advances to help people who ...
... by how long it took his computer to boot up, ... cheap and can store enormous quantities of data, but they ... are lost while information is transferred from the hard disk ... of lost productivity and energy consumption runs into the hundreds ...
Cached Biology Technology:Elsevier Sponsors 2010 Semantic Web Challenge 2Elsevier Sponsors 2010 Semantic Web Challenge 3Elsevier Sponsors 2010 Semantic Web Challenge 4Elsevier Sponsors 2010 Semantic Web Challenge 5Elsevier Sponsors 2010 Semantic Web Challenge 6Elsevier Sponsors 2010 Semantic Web Challenge 7Elsevier Sponsors 2010 Semantic Web Challenge 8Elsevier Sponsors 2010 Semantic Web Challenge 9Elsevier Sponsors 2010 Semantic Web Challenge 10Elsevier Sponsors 2010 Semantic Web Challenge 11Virtual reality helps researchers track how brain responds to surroundings 2Racetrack memory 2
(Date:4/15/2014)... (April 15, 2014) The American Association of Anatomists ... All awards will be presented during the Closing ... Hotel on Tuesday, April 29th at 7:30 p.m. during ... , The 2014 award winners are: , ... PhD, of the Icahn School of Medicine at Mount ...
(Date:4/15/2014)... are many viral diseases in the world for which ... fever, which is spread by mosquitoes in the tropics, ... more familiar in Finland and is easily spread by ... children and the elderly. , Researchers at Aalto University ... in preliminary tests to prevent the spread of one ...
(Date:4/15/2014)... University of Adelaide research into parasites of cuttlefish, ... parasites, astonishing life cycles, and shown how they ... , Researcher Dr Sarah Catalano has described 10 ... in the kidneys of cephalopods (cuttlefish, squid and ... species to be described from Australian waters. ...
Breaking Biology News(10 mins):American Association of Anatomists 2014 award winners 2Nanocrystalline cellulose modified into an efficient viral inhibitor 2Bizarre parasite may provide cuttlefish clues 2
... you know and where you,re positioned on the social ... for food. At least that,s the case with African ... the University of California, Berkeley, who collaborated with researchers ... in Kenya, and at the University of Oxford in ...
... been brought back to life in stunning 3D by ... a paper published in the latest issue of the ... University in Belgium report on the use of a ... to digitally dissect tiny fossils and reveal the preservation ...
... Gene therapy administered intravenously could be an effective ... effects of ionizing radiation in the event of large-scale ... an animal study presented today by University of Pittsburgh ... Society for Therapeutic Radiology and Oncology (ASTRO) in Los ...
Cached Biology News:Social standing influences elephant movement 2Social standing influences elephant movement 3Scientist brings 50 million year old spider 'back to life' 2Intravenous gene therapy protects normal tissue of mice during whole-body radiation 2
... Combining linear motor and ballscrew ... pre-engineered Cartesian solutions that include ... management, and motors., , ... Pass through high-flex cabling for ...
UGT1A6 (D-20)...
... T Squareds patented high efficiency dynamic valve ... With the most compact, lightweight package in ... use in portable air and gas applications., ... high efficiency. , Includes DC Motor. ...
... designed for moving loads quickly and accurately. ... output while limiting overall size. The P5S-P ... ball bearings guided on two rails., ... provide energy absorption and controlled deceleration , ...
Biology Products: