Navigation Links
Ubiquitin/Proteasome Fraction II Extract from GeneTex

ProductsUbiquitin/Proteasome Fraction II Extract from GeneTex
Company GeneTex
Item Ubiquitin/Proteasome Fraction II Extract
Price $380.00
Description Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80878 is the protein fraction of cell extract that binds to anion exchange resin. This fraction is essentially ubiquitin-free and ATP-free. GTX80878 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes (E2s), ubiquitin C-terminal hydrolases (UCHs) and the 20S and 26S proteasomes. GTX80878 is ideal for demonstrating ubiquitin and/or ATP dependent degradation of in vitro substrates.

  • Type: Proteins and peptides
  • Form: 11.0 mg/ml protein from rabbit reticulocytes in 25 mM HEPES, pH 7.6.
Info GeneTexGeneTex
14785 Omicron Dr. Suite101
San Antonio, TX 78245
Customer Service: (877) 436-3839
Fax Number: (210) 677-8843
Web Site: http://www.genetex.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. ProteomeLab PF 2D Protein Fractionation System from Beckman Coulter
2. UBC Fractions Extract from GeneTex
3. 26S Proteasome Fraction Extract from GeneTex
4. Ubiquitin Fraction I from ABR-Affinity BioReagents
5. 26S Proteasome Fraction Extract from GeneTex
6. Ubiquitin Fraction I Extract from GeneTex
7. FractionPREP Cell Fractionation Kit from BioVision
8. cDNA Size Fractionation Columns from Invitrogen
9. ZOOM® IEF Fractionator from Invitrogen
10. Nuclear / Cytosol Fractionation Kit from MBL International
11. Mitochondria / Cytosol Fractionation Kit from MBL International
... Fujifilm Life Science FLA-8000 Fluorescent Image Analyzer ... a single laser imaging system. This powerful ... labeled with fluorescent dyes or radioisotopes at ... demanding laboratories. Speed, image quality and flexibility ...
... cover slips for in situ hybridization,in ... on glass slides., Constant probe ... not adsorb probes. , Ready-to-use-Hybri-slips do ... , Avoid RNA degradation-Hybri-slips are supplied ...
...
...
Biology Products:
(Date:1/22/2015)... 2015  Today, FreeWavz ( www.FreeWavz.com ), the developer ... on Fundable, https://www.fundable.com/freewavz . FreeWavz will be ... to meet customer demand. Logo - ... Invented by Dr. ...
(Date:1/22/2015)... N.C. , Jan. 16, 2015  A man-made form ... memory and other mental capabilities in adults with mild ... pilot study led by researchers at Wake Forest Baptist ... adults diagnosed with amnesic mild cognitive impairment (MCI) or ...
(Date:1/22/2015)... Report Issued by Small Cap IR. In 2011, Nilson Report,s ... at merchants on the leading payment cards rose to $135.3 ... and prepaid cards reached 6.54 billion.  Eight million credit card ... in 2012, and credit and debit card fraud resulted in ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... John Smol of Queen,s University in Kingston, Ontario, Canada, ... one of the five prestigious Premier,s Discovery Awards for 2009. ... of the Environmental Scientists of the Year by The Royal ... is series editor of the Springer book series Developments in ...
... Mass., June 2, 2009 -- New research shows some bees ... hind legs while flying. But this approach comes at a ... flight by roughly 30 percent, and cutting into the bees, ... Proceedings of the National Academy of Sciences . ...
... Ocean acidification, a direct result of increased CO2 emission, ... and may have a direct impact on our economy, ... Intensive fossil-fuel burning and deforestation over the last ... 40%, which has in turn fundamentally altered ocean chemistry ...
Cached Biology News:Springer Series editor John Smol receives two prestigious biology awards 2Trading energy for safety, bees extend legs to stay stable in wind 2Who will pick up the bill? 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
(Date:1/22/2015)... Geneva, Switzerland (PRWEB) January 22, 2015 ... for characterized mammalian Research Cell Banks (RCBs) used for ... generated Research Cell Banks will include Next-Generation Sequencing ... cell’s genetic architecture de-risks biologic manufacturing by ensuring the ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... has been honored for its commitment to sustainability with inclusion ... Varian is the highest ranked healthcare equipment company among the ... during the World Economic Forum at Davos, Switzerland ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Varian Honored Among World's 100 Most Sustainable Corporations 2