Navigation Links
Ubiquitin Fraction I from ABR-Affinity BioReagents

ProductsUbiquitin Fraction I from ABR-Affinity BioReagents
Company ABR-Affinity BioReagents
Item Ubiquitin Fraction I
Price $355.00
Description Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome.

EP-500 is the protein fraction of HeLa cell extract that does not bind to anion exchange resin. EP-500 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). EP-500 is ideal for demonstrating if FI enzymes are critical for degradation of in vitro substrates as well as in vitro conjugation activity.

Info ABR-Affinity BioReagentsABR-Affinity BioReagents
ABR-Affinity BioReagents Inc.
4620 Technology Drive, Suite 600
Golden, CO 80403
USA

Customer Service: +1.800.527.4535
Fax Number: +1.303.278.2424
Web Site: http://www.bioreagents.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Ubiquitin/Proteasome Fraction II Extract from GeneTex
2. Ubiquitin Fraction I Extract from GeneTex
3. Mouse Anti-Ubiquitin, Multi Monoclonal Antibody, Unconjugated, Clone FK2 from Assay Designs/Stressgen Bioreagents
4. Ubiquitin Related I Sampler Kit from BD Biosciences Pharmingen
5. Rabbit Anti-Human Ubiquitin-conjugating enzyme E2N Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.
6. ProteomeLab PF 2D Protein Fractionation System from Beckman Coulter
7. UBC Fractions Extract from GeneTex
8. 26S Proteasome Fraction Extract from GeneTex
9. 26S Proteasome Fraction Extract from GeneTex
10. FractionPREP Cell Fractionation Kit from BioVision
11. cDNA Size Fractionation Columns from Invitrogen
ma. plate stack height 70mm...
Rotor for four tube-loaded buckets; ma RCF 2550g; sold without buckets...
CQCS kit for etra KR 4i , (other units)....
A compact, high-speed single tube reader unit designed for benchtop 2D barcode reading. The unit can be used with all of ABgene's 2D barcoded tubes, including the 2ml CryoCode tube....
Biology Products:
(Date:10/30/2014)... news release is available in German . ... as individuals prompt our fellow humans to behave socially? ... social dilemmas in game theory. Previous studies assumed that ... groups. Nonetheless, scientists from the Max Planck Institute for ... can exert an influence on the cooperative behaviour of ...
(Date:10/30/2014)... North Carolina State University researchers have developed a suite ... between dogs and humans, which has applications in everything ... our pets. , "We,ve developed a platform for computer-mediated ... to new avenues for interpreting dogs, behavioral signals and ... Dr. David Roberts, an assistant professor of computer science ...
(Date:10/29/2014)... oil and gas production are well over recommended levels ... access journal Environmental Health . High levels of ... is the first to be based on community sampling ... be used to supplement official air-quality monitoring programs. , ... not readily flow to the surface. This is because ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4New tech aims to improve communication between dogs and humans 2Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3
... not all plants from the same species can be ... only prevent the exchange of genes between well-established species ... but also between varieties of one and the same ... if one wants to understand the origin of biodiversity. ...
... global inventory of farm animals showing many breeds of ... extinction, scientists from the Consultative Group on International Agricultural ... genebanks to conserve the sperm and ovaries of key ... An over-reliance on just a few breeds of ...
... clear nearly a century ago that many genes likely influence ... has followed in defining the myriad genes. Now an international ... a genetic variant associated with human height the first ... in the September 2 advance online edition of Nature Genetics, ...
Cached Biology News:How the plant immune system can drive the formation of new species 2How the plant immune system can drive the formation of new species 3Report: African, Asian, Latin American farm animals face extinction 2Report: African, Asian, Latin American farm animals face extinction 3Report: African, Asian, Latin American farm animals face extinction 4Genome study shines light on genetic link to height 2Genome study shines light on genetic link to height 3
(Date:10/30/2014)... 2014  Ardelyx, Inc. (NASDAQ: ARDX ... gastrointestinal and metabolic diseases, today announced that it ... Thursday, November 6, 2014. Following the announcement, the ... call and webcast at 4:30pm ET to review ... update. The live webcast can be ...
(Date:10/30/2014)... 30, 2014 SoundConnect , ... offers Office 365 end users the key to ... phone system by adding voice enablement and hybrid ... Lync Online, a communication tool that includes presence, ... hosted voice, O365 becomes a comprehensive unified communications ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Whitehouse Laboratories ... its ICH Stability Testing and Package Test Capacity. Responding ... centers on a dramatic increase in environmental chamber storage ... stability, storage and aging samples to be securely held ... this major capital expenditure has already taken place with ...
(Date:10/30/2014)... A new report, commissioned by BioCrossroads and ... in-depth look at Indiana,s capital ... two different time frames: 1993 to 2002 and 2003 ... opportunities for investment growth.  The Life Science Innovation ... gains in innovation dollars as well as an increase ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5