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Rabbit Anti-Aph-1aL, S Loop (92-115) Polyclonal Antibody, Unconjugated from Covance Research Products, Inc

ProductsRabbit Anti-Aph-1aL, S Loop (92-115) Polyclonal Antibody, Unconjugated from Covance Research Products, Inc
Company Covance Research Products, Inc
Item Rabbit Anti-Aph-1aL, S Loop (92-115) Polyclonal Antibody, Unconjugated
Price $353.00
Description Polyclonal Antibody against Aph-1a (Aph-1aL,S Loop 92-115), O2F1

Affinity Purified Antibody

The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic activity. The gamma secretase complex catalyzes cleavage of a number of integral membrane proteins including Amyloid precursor protein, Notch, Erb4 and E-cadherin. While Aph-1 stabilizes the presenilin holoprotein within the gamma secretase complex, Pen-2 is required for endoproteolysis of presenilin and activation of the gamma secretase.
The Aph-1 homologue on human chromosome 1 is termed Aph-1a and on human chromosome 15 is referred to as Aph-1b. The antibody Aph-1aL/SLoop (O2F1) was raised against the human Aph-1aL/S Loop region 92-115 and recognizes the sequence CKLLKKADEGLASLSEDGRSPISIR.
Covance also offers an antibody O2C2 (PRB-550P) which recognizes the C terminal sequence 245-265 of Aph-1aL.

This antibody is effective in immunoblotting and immunostaining.

Info Covance Research Products, IncCovance Research Products, Inc
P.O. Box 7200
Denver, Pennsylvania 17517

Customer Service:
800-345-4114 (Toll Free)
717-336-4921

Fax Number:
717-336-5344

Web Site: http://www.crpinc.com
NOTE: Price information is approximate list price and actual prices may vary.

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