|Products||Rabbit Anti-Aph-1aL, S Loop (92-115) Polyclonal Antibody, Unconjugated from Covance Research Products, Inc|
|Company||Covance Research Products, Inc|
|Item||Rabbit Anti-Aph-1aL, S Loop (92-115) Polyclonal Antibody, Unconjugated|
|Description|| Polyclonal Antibody against Aph-1a (Aph-1aL,S Loop 92-115), O2F1|
Affinity Purified Antibody
The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic activity. The gamma secretase complex catalyzes cleavage of a number of integral membrane proteins including Amyloid precursor protein, Notch, Erb4 and E-cadherin. While Aph-1 stabilizes the presenilin holoprotein within the gamma secretase complex, Pen-2 is required for endoproteolysis of presenilin and activation of the gamma secretase.
This antibody is effective in immunoblotting and immunostaining.
|Info|| Covance Research Products, Inc|
P.O. Box 7200
Denver, Pennsylvania 17517
800-345-4114 (Toll Free)
Web Site: http://www.crpinc.com