Navigation Links
Qpatch HT from Sophion Bioscience

ProductsQpatch HT from Sophion Bioscience
Company Sophion Bioscience
Item Qpatch HT
Price Inquire
Description Sophions newly introduced QPatch HT is taking automated patch clamping to a new and even more powerful level. With its ability to generate thousands of high quality data points daily, QPatch HT is enabling new screening paradigms in ion channel drug discovery and safety testing. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. This can be expected to further fuel the revolution in ion channel drug discovery and safety testing.

The QPatch HT is a 48-channel gigaseal patch clamp system that can be applied to both voltage-gated and ligand-gated ion channels. The system includes 48 individual low-noise patch clamp amplifiers and pressure controllers. Independent pressure control (i.e. suction on each cell individually) is important because each cell performs uniquely. Gigaseals and/or whole cells are obtained with some cells quickly while with other cells more slowly.

The QPatch HT has eight pipettes attached to the fluid handling robot to keep pace with the liquid handling demand of up to 48 simultaneous patch clamp experiments. For comparison the QPatch 16 has four pipettes. To further optimize system performance, an intelligent, forward-looking strategy for allocation of the pipettes to the actual liquid application tasks has been implemented in the QPatch HT. Especially for ligand-gated ion channel applications the eight intelligently moving pipettes are leading to a significantly increased throughput compared to todays automated patch clamp systems.

The 48-channel QPlate measurement plate builds on the same technology as the original 16-channel QPlate. The individual measurement sites include glass-coated microfluidic channels for less compound absorption and hence more accurate IC50-values. The microfluidic channels require only small volumes of liquid for each experiment (approximately 5 l) and enable cumulative dose-response experiments or screening of multiple compounds on the same cell. The liquid exchange time is ~ 100 ms.

The unique automated cell preparation station is also a popular feature from the QPatch 16. It keeps the cells in suspension until the experiment begins. Prior to application to the QPlate, cells are transferred to the on-board centrifuge where they are spun down and resuspended in the extracellular ringer solution to a concentration that ensures optimal success rates. Elevator units for stacking and feeding compound plates and QPlates are featured in the QPatch HT. Together with the cell preparation station, the elevator units ensure more than four hours of unattended operation with the QPatch HT. This, for instance, means that the system can be put to work after normal working hours, thus enhancing daily throughput.

While automated patch clamping has lead to significantly increased data throughput, a new bottleneck of data analysis has emerged in the horizon. The new QPatch Assay Software offers elegant automated data analysis features to efficiently remove that bottleneck.

Info Sophion BioscienceSophion Bioscience
Sophion Bioscience, Inc. (USA Office)
P.O. Box 83
Annandale, NJ 08801 USA

Sophion Bioscience A/S
Baltorpvej 154
DK-2750 Ballerup
Denmark


Customer Service: (908) 638-6589
Fax Number: (908) 638-6374
Web Site: http://www.sophion.dk
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. QPatch 16 from Sophion Bioscience
2. Qplate from Sophion Bioscience
3. Mouse Anti-Mouse Glutathione S-transferase M1 (GSTM1) Monoclonal Antibody, Unconjugated from Lifespan Biosciences
4. Rabbit Anti-Human Vitamin K-dependent Protein S (PROS1) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
5. Rabbit Anti-Human Sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7 (SIRT7) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
6. BD Pathway 435 confocal bioimager from BD Biosciences - Bioimaging
7. Hybridoma Development from QED Bioscience Inc.
8. Random DNA mutagenesis Service from Yorkshire Bioscience Ltd
9. BD Pathway 415 bioimager from BD Biosciences - Bioimaging
10. SphingoBeads from Echelon Biosciences Inc.
11. BD Falcon Roller Bottle, smooth surface from BD Biosciences - Discovery Labware
Porcine Coronary Artery Smooth Muscle Cells (PCASMC) (>500,000 cells)...
... T4 DNA Ligase catalyzes the joining of ... and the 3´-hydroxyl groups of adjacent nucleotides ... (1). The enzyme has also been shown ... either a DNA or RNA strand in ...
... Chain MAP1A and MAP1B are microtubule-associated proteins ... components of the cytoskeleton. MAP1A and MAP1B each ... light chain subunits. The protein encoded by this ... and can associate with either MAP1A or MAP1B. ...
PC based system for advanced chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
Biology Products:
(Date:10/16/2014)... challenged conventional thinking on how the bowel lining develops ... how bowel cancer starts. , The researchers produced evidence ... the ,crypts, that are a feature of the bowel ... bowel cancer development, a controversial finding as scientists are ... 3D imaging technologies, Dr Chin Wee Tan and Professor ...
(Date:10/16/2014)... Syncytial Virus causes severe respiratory tract infections and ... year. Scientists at VIB and Ghent University have ... counteract this common virus infection. , Xavier ... that paves the way for the development of ... virus that causes suffering in numerous small children ...
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... leading edge technologies including Wocket™, the Smart Wallet, at ... Conferenece. FiRe is a leading global conference on the ... Hosted by Mark Anderson , founder and publisher ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2New perspectives for development of an RSV vaccine 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... In recent years, the possible applications for double-walled ... those working on developing renewable energy technologies. These ... thin enough to be transparent, yet can still ... advanced solar panels, sensors and a host of ...
... for Glycomics in collaboration with colleagues at the ... to identifying a broad spectrum treatment for the ... These highly-infectious viruses are the leading cause of ... of hospitalisations in the developed world, and hundreds ...
... Dec. 23, 2008 -- The reproductive spores of many ... to new research by mycologists and applied mathematicians at ... this week in the Proceedings of the National ... fungal spores is within one percent of the absolute ...
Cached Biology News:Researchers find chink in the armor of viral 'tummy bug' 2In many fungi, reproductive spores are remarkably aerodynamic 2
(Date:10/25/2014)... Charlotte, NC (PRWEB) October 24, 2014 ... high intensity focused ultrasound (HIFU) technology, announced that ... Carol, M.D. as Chief Executive Officer, President and ... new role Dr. Carol will take-on expanded responsibilities ... HIFU technology, as well as overseeing commercialization, manufacturing ...
(Date:10/25/2014)... JERUSALEM , October 24, 2014 ... a clinical-stage pharmaceutical company focused on the development of ... CEO, Nadav Kidron will present at FireRock ... ,FireRock Capital,s Annual Micro-Cap Conference ,Date: Tuesday, October 28, ... Building, New York City , ...
(Date:10/25/2014)... 2014 Investor-Edge has initiated coverage ... CYTR ), Vertex Pharmaceuticals Inc. (NASDAQ: VRTX ... Peregrine Pharmaceuticals Inc. (NASDAQ: PPHM ), and ... companies can be accessed at: http://investor-edge.com/register . ... ended on a positive note as the Dow Jones ...
(Date:10/22/2014)... 22, 2014 New test innovations will be ... diagnostic (IVD) test industry, especially as companies struggle with ... listed more than 25 testing innovations in important disease ... of IVD products. Kalorama details the new approaches its biennial ... for In Vitro Diagnostic Tests , 9th Edition ...
Breaking Biology Technology:SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 2SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 3Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3