Navigation Links
Qpatch HT from Sophion Bioscience

ProductsQpatch HT from Sophion Bioscience
Company Sophion Bioscience
Item Qpatch HT
Price Inquire
Description Sophions newly introduced QPatch HT is taking automated patch clamping to a new and even more powerful level. With its ability to generate thousands of high quality data points daily, QPatch HT is enabling new screening paradigms in ion channel drug discovery and safety testing. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. This can be expected to further fuel the revolution in ion channel drug discovery and safety testing.

The QPatch HT is a 48-channel gigaseal patch clamp system that can be applied to both voltage-gated and ligand-gated ion channels. The system includes 48 individual low-noise patch clamp amplifiers and pressure controllers. Independent pressure control (i.e. suction on each cell individually) is important because each cell performs uniquely. Gigaseals and/or whole cells are obtained with some cells quickly while with other cells more slowly.

The QPatch HT has eight pipettes attached to the fluid handling robot to keep pace with the liquid handling demand of up to 48 simultaneous patch clamp experiments. For comparison the QPatch 16 has four pipettes. To further optimize system performance, an intelligent, forward-looking strategy for allocation of the pipettes to the actual liquid application tasks has been implemented in the QPatch HT. Especially for ligand-gated ion channel applications the eight intelligently moving pipettes are leading to a significantly increased throughput compared to todays automated patch clamp systems.

The 48-channel QPlate measurement plate builds on the same technology as the original 16-channel QPlate. The individual measurement sites include glass-coated microfluidic channels for less compound absorption and hence more accurate IC50-values. The microfluidic channels require only small volumes of liquid for each experiment (approximately 5 l) and enable cumulative dose-response experiments or screening of multiple compounds on the same cell. The liquid exchange time is ~ 100 ms.

The unique automated cell preparation station is also a popular feature from the QPatch 16. It keeps the cells in suspension until the experiment begins. Prior to application to the QPlate, cells are transferred to the on-board centrifuge where they are spun down and resuspended in the extracellular ringer solution to a concentration that ensures optimal success rates. Elevator units for stacking and feeding compound plates and QPlates are featured in the QPatch HT. Together with the cell preparation station, the elevator units ensure more than four hours of unattended operation with the QPatch HT. This, for instance, means that the system can be put to work after normal working hours, thus enhancing daily throughput.

While automated patch clamping has lead to significantly increased data throughput, a new bottleneck of data analysis has emerged in the horizon. The new QPatch Assay Software offers elegant automated data analysis features to efficiently remove that bottleneck.

Info Sophion BioscienceSophion Bioscience
Sophion Bioscience, Inc. (USA Office)
P.O. Box 83
Annandale, NJ 08801 USA

Sophion Bioscience A/S
Baltorpvej 154
DK-2750 Ballerup
Denmark


Customer Service: (908) 638-6589
Fax Number: (908) 638-6374
Web Site: http://www.sophion.dk
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. QPatch 16 from Sophion Bioscience
2. Qplate from Sophion Bioscience
3. Mouse Anti-Mouse Glutathione S-transferase M1 (GSTM1) Monoclonal Antibody, Unconjugated from Lifespan Biosciences
4. Rabbit Anti-Human Vitamin K-dependent Protein S (PROS1) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
5. Rabbit Anti-Human Sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7 (SIRT7) Polyclonal Antibody, Unconjugated from Lifespan Biosciences
6. BD Pathway 435 confocal bioimager from BD Biosciences - Bioimaging
7. Hybridoma Development from QED Bioscience Inc.
8. Random DNA mutagenesis Service from Yorkshire Bioscience Ltd
9. BD Pathway 415 bioimager from BD Biosciences - Bioimaging
10. SphingoBeads from Echelon Biosciences Inc.
11. BD Falcon Roller Bottle, smooth surface from BD Biosciences - Discovery Labware
... For nucleofection of optimized cell lines in ... the nucleofection parameters. Nucleofector Kits are only ... Different cell lines can be transfected with ... are given in brackets in percent (Efficiency ...
... Human Pathogenic Viruses The National ... preserves well characterised, authenticated human ... facility, and NCPV is able ... nucleic acids derived from them, ...
B-FABP (FL-132)...
... a highly purified preparation of the catalytic ... which recognizes the identical cleavage site as ... enzymatic activity (1). Novagen&'s enzyme is produced ... the highest activity available, and is qualified ...
Biology Products:
(Date:9/2/2014)... hard to comprehend how bad the current rate of ... what it was before people came along. The newest ... lower than scientists had thought, which means that the ... about 1,000 times more frequent now than in the ... from lead author Jurriaan de Vos, a Brown University ...
(Date:9/2/2014)... of the University of Granada has revealed new data ... Iberian Peninsula around the mid Holocene (around 6.000 years ... the Sahara increased. The data came from a study ... Sierra Nevada (Granada) , This study, published in the ... sedimentation of atmospheric dust from the Sahara, a very ...
(Date:9/2/2014)... that professional baseball pitchers with poor core stability are more ... season because of injury than are pitchers who have good ... In the study, 347 pitchers were assessed for lumbopelvic control ... as they raised a leg to step up were up ... days cumulative, not consecutive during the season than ...
Breaking Biology News(10 mins):Extinctions during human era worse than thought 2Extinctions during human era worse than thought 3Scientists obtain new data on the weather 10,000 years ago from sediments of a lake in Sierra Nevada 2In pro baseball pitchers, weak core linked to more missed days 2In pro baseball pitchers, weak core linked to more missed days 3
... is to fund research exploring the link between Bisphenol A ... heart disease. The grant is for 119,169. In the ... have suggested that some manmade chemicals might be linked to ... used in some types of plastic containers. A ...
... An award-winning nature essay, written during a USDA Forest ... for nature writing. The essay, "Mind in the Forest," ... Indiana University, stresses the author,s connection with nature, especially ... issue of how humans engage with the natural world. ...
... Plants respond to attacks by herbivores or pathogens by ... the attackers. These defense responses require a great deal ... be invested in growth and reproduction. So, it,s very ... Hormones, such as the jasmonates, are crucial in this ...
Cached Biology News:Nature essay made possible by Forest Service program, is Orion Magazine selection 2Biologists discover an on/off button on plants' alarm system 2
(Date:9/2/2014)... YORK , September 2, 2014 ... Study on Membrane Technology in Pharmaceutical, Biopharma and Life ... Highest Growth by 2019" the global membrane technology market for pharmaceutical, ... million in 2014 and is expected to grow at ... reach an estimated value of USD 10,886.0 million in ...
(Date:9/2/2014)... Sept. 2, 2014  TransCelerate BioPharma Inc. ("TransCelerate") ... approach for protecting personal data in Clinical Study ... and others. The document describes an approach to ... CSRs and other related clinical trial documents, and ... goal of the TransCelerate CSR Redaction approach is ...
(Date:9/2/2014)... -- Technology Applications International Corporation (the "Company" or "NUUU")(OTC BB: ... Inc. has signed an additional exclusive licensing agreement with ... Johnson Space Center in Houston , ... Charles J. Scimeca , NUUU,s ... latest, exclusive agreement with NASA. In addition to our ...
(Date:9/2/2014)... Myriant Corporation, a global renewable chemicals ... agreement with Azelis Group, a specialty chemicals distribution ... in the Nordics, Benelux, France, Iberia, Italy, the ... industrial and base chemicals markets. , “As a ... chemical portfolio with extensive distribution networks providing Myriant ...
Breaking Biology Technology:Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 2Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 3Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 4Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 5TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 2TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 3Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2