Navigation Links
Fragment Library I: Large Volume with mixtures from ActiveSight

ProductsFragment Library I: Large Volume with mixtures from ActiveSight
Company ActiveSight
Item Fragment Library I: Large Volume with mixtures
Price 
Description 

A ready-to-use kit for a single fragment based screening project:

384 Individual compounds (5 uL each)

96 shape-diverse mixtures of 4 (5 uL each)

PDB and dictionary files for structure refinement

Individual compounds are dissolved in DMSO at ca. 200 mM, mixtures of 4 are at ca. 50 mM. Supplied in 5 96-well trays. Dilute library with protein crystallization solution to make soak solutions for a complete structure based fragment screening project. Includes CD-ROM containing a full description of each fragment including pdb and cif files for fitting and refinement with MIFit, CCP4 and other popular crystallographic software.

ActiveSight Fragment Library I consists of small fragments of "drug-like" molecules used to probe the functionality and shape of a protein binding site. The small size of the fragments allows "room to grow" through chemical elaboration to generate novel leads with high potency.

The majority of the compounds in library I consist of a single rigid core decorated with 1-3 short side groups. Average molecular weight of 142 Da; 95% of library members have weights in the range of 90-220 Da. Scaffolds include benzenes, pyridines, pyrimidines, indoles, indazoles, benzimidazoles, purines, pyrazoles, pteridines, cyclohexanes, napthalenes, quinolines, isoquinolines, quinazolines, piperidines, isoxazoles, oxazoles, thiazoles, and furans.

Sidegroups include -NH2, -OH, -CH3, -C(=O)(-NH2), -Br, -C-NH2, =O, -C(=O)(-OH), -F, -Cl, -SH, -CF3, -C(=O)(-NHOH),=NH,-C(=NH)(-NH2), -S(=O)(=O)(-NH2), -C(=O)(-CH3), -O-CH3, -C-OH

The fragments can be used singly or as mixtures to decrease the number of soaks and data sets needed. All of the fragments are commercially available for further chemical synthesis. Buying the library pre-made in plates will save considerable time and effort.

Info ActiveSightActiveSight
4045 Sorrento Valley Blvd.
San Diego, CA 92121 USA
Customer Service: 858-455-6870
Fax Number: 858-455-6932
Web Site: http://www.active-sight.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Fragment-based Screening Services from ActiveSight
2. DNA Polymerase I Large (Klenow) Fragment from New England Biolabs
3. Exo- Klenow Fragment (Cloned) from Ambion
4. DNA Polymerase I Large (Klenow) Fragment from Invitrogen
5. Klenow Fragment, Exonuclease Minus from Promega
6. ApoDIRECT DNA Fragmentation Assay Kit from MBL International
7. ApoBrdU DNA Fragmentation Assay Kit from MBL International
8. ApoBrdU Red DNA Fragmentation Kit from MBL International
9. Anti-Human IgG, Fd Fragment Monoclonal Antibody, Unconjugated from CHEMICON
10. DNA Fragment 2X Precipitation Solution from EPICENTRE Biotechnologies
11. Duck Anti-Cobra venom - Fab Fragment Polyclonal Antibody, Unconjugated from Abcam
... 45° Fixed Angle Rotor for ... CL2, Centra CL3CL3R, and Centra-MP4/MP4R. ... of sputum samples and other ... Provides individual aerosol containment. Complete ...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Buckets for tube holder inserts...
Rotor for four tube-loaded buckets; ma RCF 2550g; sold without buckets...
Biology Products:
(Date:11/30/2016)... and WARSAW, Poland , Nov. 30, 2016 Not ... one of the most crucial aspects of recovery so we need to do it ... health risks, including heart problems, high blood pressure, stroke, diabetes, and even cancer. ... sleep and find a Christmas present that could help them to manage their sleep ... ...
(Date:11/29/2016)... -- Nearly one billion matches per second with DERMALOG,s high-speed ... ... DERMALOG is Germany's largest Multi-Biometric supplier: ... (PRNewsFoto/DERMALOG Identification Systems) ... is Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part ...
(Date:11/22/2016)... 22, 2016   MedNet Solutions , an innovative ... of clinical research, is pleased to announce that the ... and Life Sciences Awards as "Most Outstanding in ... unprecedented year of recognition and growth for MedNet, which ... years. iMedNet ™ , MedNet,s ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... USA, and CARDIFF, UK (PRWEB) , ... December ... ... with very high precision light to control cells — optogenetics — is key ... the current state of the art, spatially patterned light projected via free-space optics ...
(Date:12/8/2016)... 2016 Oxford Gene ... seine Palette an anpassbaren SureSeq™ NGS-Panels mit dem ... das ein schnelles und kostengünstiges Studium der Varianten ... eine Erkennung von Einzel-Nukleotid-Variationen (Single Nucleotide Variation, SNV) ... kleinen Panel und ermöglicht eine individuelle Anpassung durch ...
(Date:12/8/2016)... Dec. 8, 2016  Anaconda BioMed S.L., a pre-clinical ... the next generation neuro-thrombectomy system for the treatment of ... G. Jovin, MD to join its Scientific Advisory Board ... strategic network of scientific and clinical experts to Anaconda ... the ANCD BRAIN ® to its clinical phase. ...
(Date:12/8/2016)... , ... December 08, 2016 ... ... the commercial launch of flexible packaging for their exceptionally efficient human mesenchymal ... system extends RoosterBio’s portfolio of bioprocess media products engineered to radically streamline ...
Breaking Biology Technology: