Navigation Links
Fragment Library I: Large Volume with mixtures from ActiveSight

ProductsFragment Library I: Large Volume with mixtures from ActiveSight
Company ActiveSight
Item Fragment Library I: Large Volume with mixtures
Price 
Description 

A ready-to-use kit for a single fragment based screening project:

384 Individual compounds (5 uL each)

96 shape-diverse mixtures of 4 (5 uL each)

PDB and dictionary files for structure refinement

Individual compounds are dissolved in DMSO at ca. 200 mM, mixtures of 4 are at ca. 50 mM. Supplied in 5 96-well trays. Dilute library with protein crystallization solution to make soak solutions for a complete structure based fragment screening project. Includes CD-ROM containing a full description of each fragment including pdb and cif files for fitting and refinement with MIFit, CCP4 and other popular crystallographic software.

ActiveSight Fragment Library I consists of small fragments of "drug-like" molecules used to probe the functionality and shape of a protein binding site. The small size of the fragments allows "room to grow" through chemical elaboration to generate novel leads with high potency.

The majority of the compounds in library I consist of a single rigid core decorated with 1-3 short side groups. Average molecular weight of 142 Da; 95% of library members have weights in the range of 90-220 Da. Scaffolds include benzenes, pyridines, pyrimidines, indoles, indazoles, benzimidazoles, purines, pyrazoles, pteridines, cyclohexanes, napthalenes, quinolines, isoquinolines, quinazolines, piperidines, isoxazoles, oxazoles, thiazoles, and furans.

Sidegroups include -NH2, -OH, -CH3, -C(=O)(-NH2), -Br, -C-NH2, =O, -C(=O)(-OH), -F, -Cl, -SH, -CF3, -C(=O)(-NHOH),=NH,-C(=NH)(-NH2), -S(=O)(=O)(-NH2), -C(=O)(-CH3), -O-CH3, -C-OH

The fragments can be used singly or as mixtures to decrease the number of soaks and data sets needed. All of the fragments are commercially available for further chemical synthesis. Buying the library pre-made in plates will save considerable time and effort.

Info ActiveSightActiveSight
4045 Sorrento Valley Blvd.
San Diego, CA 92121 USA
Customer Service: 858-455-6870
Fax Number: 858-455-6932
Web Site: http://www.active-sight.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Fragment-based Screening Services from ActiveSight
2. DNA Polymerase I Large (Klenow) Fragment from New England Biolabs
3. Exo- Klenow Fragment (Cloned) from Ambion
4. DNA Polymerase I Large (Klenow) Fragment from Invitrogen
5. Klenow Fragment, Exonuclease Minus from Promega
6. ApoDIRECT DNA Fragmentation Assay Kit from MBL International
7. ApoBrdU DNA Fragmentation Assay Kit from MBL International
8. ApoBrdU Red DNA Fragmentation Kit from MBL International
9. Anti-Human IgG, Fd Fragment Monoclonal Antibody, Unconjugated from CHEMICON
10. DNA Fragment 2X Precipitation Solution from EPICENTRE Biotechnologies
11. Duck Anti-Cobra venom - Fab Fragment Polyclonal Antibody, Unconjugated from Abcam
Purified anti-SOCS3...
Monoclonal Antibody toSynapsin I a and I b Neurofilament associated protein from mouse brain extracts (4)....
Human peripheral blood PBMCs, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Biology Products:
(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program ... honoring scientists who have made outstanding contributions to analytical chemistry and ... 2018, the world’s leading conference and exposition for laboratory science, which will be ...
(Date:10/9/2017)... ... 09, 2017 , ... The award-winning American Farmer television series will feature 3 ... airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten ... to continue to feed a growing nation. At the same time, many of our ...
(Date:10/9/2017)... Arizona (PRWEB) , ... October 09, 2017 , ... ... Kindred, a four-tiered line of medical marijuana products targeting the needs of consumers ... and packaging of Kindred takes place in Phoenix, Arizona. , As operators of ...
Breaking Biology Technology: