|Products||Anti-Heat Shock Protein 75 (hsp75) (TRAP-1) Ab-2 Monoclonal Antibody, Unconjugated from Lab Vision|
|Item||Anti-Heat Shock Protein 75 (hsp75) (TRAP-1) Ab-2 Monoclonal Antibody, Unconjugated|
|Description|| A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (HSPs), more appropriately called as stress response proteins (SRPs). The Hsp90 family of proteins in mammalian cells consists of Hsp90 alpha and beta, Grp94, and Trap-1 (Hsp75). It was found that human TRAP-1 is localized to mitochondria and exhibited ATPase activity that was inhibited by both geldanamycin and radicicol indicating that TRAP-1 has functions that are distinct from those of hsp90. It was also found that TRAP-1 had a biochemical activity to refold denatured retinoblastoma protein (Rb) into its native conformation.|
Species Reactivity: Human. Others-not tested.
|Info|| Lab Vision|
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