Navigation Links
26S Proteasome Fraction Extract from GeneTex

Products26S Proteasome Fraction Extract from GeneTex
Company GeneTex
Item 26S Proteasome Fraction Extract
Price $350.00
Description Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80880 contains the full Hela cell compliment of ubiquitin activating enzyme (E1), ubiquitin conjugating enzymes (E2s), 20S and 26S proteasomes, isopeptidase, proteasome PA28/11S REG complex, and ubiquitin ligase enzymes (E3s). GTX80880 is ideal for demonstrating ubiquitin proteasome degradation/conjugation of radiolabeled or immunodetectable substrates.

  • Type: Proteins and peptides
  • Form: 7.5 mg/ml in 25 mM HEPES, pH 7.6.
Info GeneTexGeneTex
14785 Omicron Dr. Suite101
San Antonio, TX 78245
Customer Service: (877) 436-3839
Fax Number: (210) 677-8843
Web Site: http://www.genetex.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. 26S Proteasome Fraction Extract from GeneTex
2. Ubiquitin/Proteasome Fraction II Extract from GeneTex
3. 20S Proteasome Fluorometric (AMC) Assay Kit from CHEMICON
4. Mouse Anti-20S Proteasome alpha1, 2, 3, 5, 6, & 7-Subunits Monoclonal Antibody, Unconjugated, Clone MCP231 from Calbiochem
5. ProteomeLab PF 2D Protein Fractionation System from Beckman Coulter
6. UBC Fractions Extract from GeneTex
7. Ubiquitin Fraction I from ABR-Affinity BioReagents
8. Ubiquitin Fraction I Extract from GeneTex
9. FractionPREP Cell Fractionation Kit from BioVision
10. cDNA Size Fractionation Columns from Invitrogen
11. ZOOM® IEF Fractionator from Invitrogen
TRIS-EDTA based buffer prepared from RNase-free water suitable for storage and dilution of siRNA, pH 8, store at 4 C ...
Request Info...
Agarose-LE, 250 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
IC50: 3 ng/ml · Limit of detection: 0.9 ng/ml...
Biology Products:
(Date:6/23/2015)... , June 23, 2015   MedNet ... that supports the entire spectrum of clinical research, ... ™ , the company,s intuitive, flexible ... awarded a Silver 2015 Stevie® Award by the ... Products & Services Website category.  The American Business ...
(Date:6/23/2015)... Fla. , June 23, 2015 /PRNewswire/ ... management and authentication solutions, today announced enhanced functionality ... multi-factor authentication solution.  The enhancements build on ... of the DigitalPersona Altus platform and provide ... compatibility. In today,s environment of ...
(Date:6/17/2015)... HILDEN , Deutschland und GERMANTOWN, Maryland ... Investigator ®   Produktlinie mit ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime ... neue STR-Testkits der Produktlinie Investigator ... DNA-Spuren in den Markt eingeführt. Die neuen Kits zur ...
Breaking Biology News(10 mins):MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6
... of the Blackleg fungus, which causes the most damaging disease ... time by a team of French and Australian scientists. ... University of Melbourne, who led the Australian research team, said ... Blackleg disease. "The 12,500 genes that constitute the genetic ...
... Optiqua Technologies Pte Ltd is collaborating with Nanyang ... in biomolecular sciences and sensor technology. Optiqua, ... provides the international water industry with innovative products ... detection of contaminants in water. The sensor technology ...
... , Scientists today agree that there are five molecules that ... an estimated five million Americans. The potency of these molecules ... Prof. Daniel Michaelson of Tel Aviv University,s Department ... Sciences has illuminating news about one of these five molecules ...
Cached Biology News:Uncovering the genome secrets of the Blackleg fungus 2Optiqua-NTU partnership to develop next-generation sensor technology 2Good diets fight bad Alzheimer's genes 2
(Date:6/30/2015)... ... 30, 2015 , ... uBiome and OpenBiome Partner for Microbiome ... fecal microbiota transplantation in C. difficile patients. , SAN FRANCISCO, uBiome and OpenBiome ... microbiota transplantation (FMT) as a treatment for Clostridium difficile infections (C. diff). , ...
(Date:6/30/2015)... , June 30, 2015  The University of ... Biosciences (CCE/Bio) and UC San Diego Extension announced ... be held Aug.  12 – 14, 2015, at ... three-day workshop provides an intense exposure to best ... and is well-suited to biologists, process engineers and ...
(Date:6/30/2015)... ... 30, 2015 , ... Smarter Alloys today announced a final ... that allows orthodontists to simultaneously apply different forces to different teeth. The additional ... thrilled about taking SmartArch one step closer to commercial availability for orthodontists and ...
(Date:6/29/2015)... ... June 29, 2015 , ... The ... 19% during the forecast period (2015 to 2020). The market is mainly driven ... and corporate funding for R&D. However, lack of adequate healthcare and research infrastructure ...
Breaking Biology Technology:uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5