Navigation Links
26S Proteasome Fraction Extract from GeneTex

Products26S Proteasome Fraction Extract from GeneTex
Company GeneTex
Item 26S Proteasome Fraction Extract
Price $350.00
Description Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80880 contains the full Hela cell compliment of ubiquitin activating enzyme (E1), ubiquitin conjugating enzymes (E2s), 20S and 26S proteasomes, isopeptidase, proteasome PA28/11S REG complex, and ubiquitin ligase enzymes (E3s). GTX80880 is ideal for demonstrating ubiquitin proteasome degradation/conjugation of radiolabeled or immunodetectable substrates.

  • Type: Proteins and peptides
  • Form: 7.5 mg/ml in 25 mM HEPES, pH 7.6.
Info GeneTexGeneTex
14785 Omicron Dr. Suite101
San Antonio, TX 78245
Customer Service: (877) 436-3839
Fax Number: (210) 677-8843
Web Site: http://www.genetex.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. 26S Proteasome Fraction Extract from GeneTex
2. Ubiquitin/Proteasome Fraction II Extract from GeneTex
3. 20S Proteasome Fluorometric (AMC) Assay Kit from CHEMICON
4. Mouse Anti-20S Proteasome alpha1, 2, 3, 5, 6, & 7-Subunits Monoclonal Antibody, Unconjugated, Clone MCP231 from Calbiochem
5. ProteomeLab PF 2D Protein Fractionation System from Beckman Coulter
6. UBC Fractions Extract from GeneTex
7. Ubiquitin Fraction I from ABR-Affinity BioReagents
8. Ubiquitin Fraction I Extract from GeneTex
9. FractionPREP Cell Fractionation Kit from BioVision
10. cDNA Size Fractionation Columns from Invitrogen
11. ZOOM® IEF Fractionator from Invitrogen
UltraMount is formulated for coverslipping sections stained with alcohol soluble chromogens, such as Fast-Red or AEC. No heating is required prior to use. Coverslips may be removed by soaking in wate...
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
...
... Fixation Buffer, used in conjunction with ... can be used to fix and ... staining of cytokines and other cytoplasmic ... been specially formulated for reducing non-specific ...
Biology Products:
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
(Date:11/7/2014)... Researchers led by Dr. Debra Auguste, associate professor, ... at The City College of New York, have ... treatment for one of the most aggressive forms ... (TNBCs) have a high mortality rate owing to ... effective therapeutic options. However, Professor Auguste,s team, discovered ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... MADISON, WI, SEPTEMBER 2, 2008 Varying the rate of ... intuitive sense, as farmers have long observed differences in ... The availability of spatial yield information from combines equipped ... improved management. So, optimizing inputs to match ...
... biomarkers for the detection of diseases including cancer and ... Cell Research . The findings pave the way ... are a class of naturally occurring small non-coding RNAs ... reporting individual miRNAs as diagnostic biomarkers of specific cancers ...
... University nanophotonics pioneer Naomi Halas has won one of ... the University of Pennsylvania,s Nano/Bio Interface Center (NBIC). ... the innovative synthesis of nanostructures. She will accept the ... ceremonies Oct. 29 in Philadelphia. Halas is the ...
Cached Biology News:A little nitrogen can go a long way 2A little nitrogen can go a long way 3
(Date:11/24/2014)... 24, 2014 Five American winners ... Al Maktoum Awards for Medical Sciences", in its 8 ... Arab Emirates , on 15 December 2014. ... The Carter Center which won the Hamdan Award ... in numerous programs that aim to improve health and ...
(Date:11/24/2014)... , Nov. 24, 2014 VolitionRx Limited ... tests for cancer and other conditions, today announced that data ... the Science for Business BioWin Day 2014, being held November ... data come from VolitionRx,s lung cancer pilot study, the samples ... Centre Hospitalier Universitaire (CHU) de Liege in Belgium ...
(Date:11/24/2014)... 2014   Veracyte, Inc. (Nasdaq: VCYT ... and chief executive officer, will present in a fireside chat ... Conference on Tuesday, December 2, 2014 at 12:30 p.m. ET ... live audio webcast and subsequent replay may be accessed by ... the website at least 15 minutes prior to the live ...
(Date:11/24/2014)... Continental Clinical Solutions, LLC (Continental) ... trials at its mid-Atlantic late-phase research facility, located ... with the idea of closing patient disparities in ... medical advances," said Continental's CEO, Saleh Stevens ... immortal cell line of Henrietta Lacks, dubious ethical ...
Breaking Biology Technology:Five US Winners Among Recipients of Hamdan Medical Awards 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3