Navigation Links
26S Proteasome Fraction Extract from GeneTex

Products26S Proteasome Fraction Extract from GeneTex
Company GeneTex
Item 26S Proteasome Fraction Extract
Price $380.00
Description Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80879 is the partially purified fraction containing 26S proteasome and none of the conjugation enzymes (E1, E2s, E3s). Preferred for the degradation of pre-formed ubiquitin-protein conjugates by the 26S proteasome since highly purified 26S is costly and more labile.

  • Type: Proteins and peptides
  • Form: 0.5 mg/ml in 50 mM HEPES, pH 7.6, 1 mM Mg-ATP, 150 mM NaCl and 10% glycerol.
Info GeneTexGeneTex
14785 Omicron Dr. Suite101
San Antonio, TX 78245
Customer Service: (877) 436-3839
Fax Number: (210) 677-8843
Web Site: http://www.genetex.com
NOTE: Price information is approximate list price and actual prices may vary.

Related biology products :

1. Ubiquitin/Proteasome Fraction II Extract from GeneTex
2. 20S Proteasome Fluorometric (AMC) Assay Kit from CHEMICON
3. 26S Proteasome Fraction Extract from GeneTex
4. Mouse Anti-20S Proteasome alpha1, 2, 3, 5, 6, & 7-Subunits Monoclonal Antibody, Unconjugated, Clone MCP231 from Calbiochem
5. ProteomeLab PF 2D Protein Fractionation System from Beckman Coulter
6. UBC Fractions Extract from GeneTex
7. Ubiquitin Fraction I from ABR-Affinity BioReagents
8. Ubiquitin Fraction I Extract from GeneTex
9. FractionPREP Cell Fractionation Kit from BioVision
10. cDNA Size Fractionation Columns from Invitrogen
11. ZOOM® IEF Fractionator from Invitrogen
GFX PCR DNA,Gel Band Purif,100, 1 EA. Category: Nucleotide Sample Handling....
Request Info...
DITHIOTHREITOL, 150UMOL, 1 EA. Dithiothreitol (DTT), 0.1 M Solution:, *0.1 M solution of DTT in high purity dH2O., *0.2 m filtered., *Storage: -20C. Category: SEQUENASE....
... 50 Microplate Reader accessory for ... analysis by extending the versatility ... Cary 50 instruments. Use it ... samples in microlitre volumes, at ...
Biology Products:
(Date:7/22/2014)... genus of planthopper known as Conosimus, which now includes ... in the southern part of the Iberian Peninsula in ... appears in the open-access Journal of Insect Science ... Conosimus baenai , has been named after Manuel ... taxonomy of Iberian Hemiptera. , Conosimus baenai ...
(Date:7/21/2014)... 2014 (Toronto) As part of a multinational, collaborative ... Health (CAMH) have helped identify over 100 locations in ... schizophrenia, in what is the largest genomic study published ... online in Nature , point to biological mechanisms ... to new approaches to treating the disorder, which has ...
(Date:7/21/2014)... of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in the ... the virus. The work, published this week in ... Society for Microbiology, indicates that further studies are needed ... the air. , MERS, a serious viral respiratory illness ... people as of June 11, according to the World ...
Breaking Biology News(10 mins):International team sheds new light on biology underlying schizophrenia 2International team sheds new light on biology underlying schizophrenia 3Middle East Respiratory Syndrome coronavirus detected in the air of a Saudi Arabian camel barn 2
... has revealed that the extremely hot, dry and windy conditions ... ,horizontal convective rolls, -similar to streamers of wind flowing through ... study is the first of its kind to produce such ... provides insights for future fire management and warning systems. ...
... looking for information on the evolution and function ... Ravosa is your man. His integrative research ... the mammalian musculoskeletal system during development and across ... increasingly central role of the chewing complex in ...
... international research collaboration recently demonstrated progress in protecting cassava ... disease, in a confined field trial in Uganda using ... planted in November 2010 following approval by the National ... in November 2011 and results were published in the ...
Cached Biology News:Unusual weather events identified during the Black Saturday bushfires 2Notre Dame researcher is shedding light on how jaws evolve 2Researchers demonstrate control of devastating cassava virus in Africa 2
(Date:7/21/2014)... July 21, 2014 Lawrence ... Investment Board (WIB) and Las Positas College (LPC) ... technical education and hands-on training for veterans, officials ... Program at Las Positas is designed to ... for engineering technician careers, and establishes a pipeline ...
(Date:7/21/2014)... (July 21, 2014) The yield so far is ... developed a low-energy, solution-based mineral substitution process to make ... use in electronics and alternative energy devices. , A ... of the July 21 issue of the journal ... research in the inorganic and nuclear chemistry fields. The ...
(Date:7/20/2014)... the process releases radioactive krypton and xenon gases. Naturally ... gas radon. A new porous material called CC3 effectively ... Nature Materials shows how: by breathing enough ... , The CC3 material could be helpful in removing ... air in buildings and also in recycling useful elements ...
(Date:7/18/2014)... LANSING, Mich. , July 18, 2014  Neogen ... Stephen Snyder , Neogen,s chief operating officer and ... said he will work as a consultant going forward ... Snyder has been in this position since ... be fulfilled by James Herbert , who has ...
Breaking Biology Technology:Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3Oregon chemists eye improved thin films with metal substitution 2A noble gas cage 2A noble gas cage 3