Navigation Links
Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

As you read this, cells in your eye are transmitting information to your brain, while cells in your heart and arteries work just as hard to keep that brain alive. Every one of these cells -- and others throughout the body -- depends on an internal process called endocytosis to keep the flow of cellular nutrients and information healthy and strong.

It's an incredibly important life process, and now researchers at Weill Medical College of Cornell University in New York City have used an exciting new technology to better understand how one key player -- a protein called clathrin -- helps regulate endocytosis like a well-oiled machine. It may also give us insights into the kinds of disease states that can happen when clathrin-regulated endocytosis goes wrong.

The findings, already published online, will appear in the April print edition of Molecular Biology of the Cell, whose editors have chosen to highlight the Weill Cornell research due to its quality and broader significance to the field.

"This is a kind of cellular fine-tuning, and we know that deficits in this fine-tuning can wreak havoc on health," said Dr. Timothy Ryan, Professor of Biochemistry at Weill Cornell Medical College. "It's well known in obesity, for example, that even a tiny change in metabolic rate results in someone becoming obese."

Endocytosis involves the shuttling back and forth of vesicles (sac-like objects) filled with nutrients, neurotransmitters, or other compounds; usually from the cell surface to the cell interior.

Previous work at Dr. Ryan's lab has helped clarify the role of some of the key players in this process, including a ubiquitous protein called clathrin, found in nearly every cell type.

"From our previous work in brain synapses, we've learned that endocytosis is a machine that really runs quite fast, and in this latest study we were trying to figure out what those speed limits are, especially with regard to varying amounts of clathrin
'"/>

Source:Cornell University


Page: 1 2 3

Related biology news :

1. Cornell finds natural selection in humans
2. Cornell researchers find serious fish virus in Northeast for first time
3. Cornell researcher helping develop quick, cheap HIV/AIDS test
4. Cornell lab confirms deadly fish virus spreading to new species
5. Researchers discover way to make cells in the eye sensitive to light
6. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
7. Researchers find how protein allows insects to detect and respond to pheromones
8. Researchers Uncover Key Step In Manufacture of Memory Protein
9. Research advances quest for HIV-1 vaccine
10. Research on Worms Yields Clues on Aging
11. Researchers reveal the infectious impact of salmon farms on wild salmon
Post Your Comments:
(Date:10/16/2014)... are anything but sustainable: environmental damage to soil ... increasingly evident. Despite their disadvantages, however, monocultures remain ... the sole possibility of achieving higher yields in ... an ecology professor at the University of Zurich, ... forestry. After all, a new study carried out ...
(Date:10/15/2014)... N.Y. , Oct. 15, 2014 ... solutions for home and community-based care, today announced ... of implementing Sandata,s Santrax® Electronic Visit Verification™ Solution ... Services is a home health company founded in ... Texas . The study ...
(Date:10/15/2014)... The Ebola virus is spreading rapidly and to an ... experienced in the past and the virus shows a ... been recorded before. For this reason, the German National ... of Science and Engineering, and the Union of the ... statement on the Ebola epidemic today. , In the ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Sandata Announces Case Study with Quality Care Services, Inc. 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... each living cell needs both to build new and ... a number of intracellular systems work in concert to ... damaged proteins. When proteins or peptides mutate, they can ... intracellular environment. In Huntington's disease (HD) the disease provoking ...
... Wildlife Conservation Society working in Iran has successfully fitted ... marking the first time this highly endangered population of ... found throughout the continent, Asiatic cheetahs now live only ... Kavir Desert. WCS's government partner in Iran, the Department ...
... An international group of scientists has announced a ... describe the activities of genes in living organisms. ... use to describe the complex events that occur ... host. Understanding these events is crucial for developing ...
Cached Biology News:Proteasome activator enhances survival of Huntington's disease neuronal model cells 2In Iran, cheetahs collared for the first time 2Uniform language for describing genes of pathogenic and beneficial microbes 2Uniform language for describing genes of pathogenic and beneficial microbes 3
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... Horovitz , Ph.D., from its board of directors effective on ... August 2003, and served as its chairman from June 2006 ... the Nominating and Corporate Governance and Audit Committees of the ... than a decade of dedicated service to GenVec, and its ...
(Date:10/20/2014)... 20, 2014 OncLive® ... Cancer Center at Thomas Jefferson University has joined ... the Strategic Alliance Partnership program, the Sidney Kimmel ... to raise awareness of the Center’s cutting-edge research ... projects. Clinicians and other health care professionals from ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is ... donor stem cells for dogs with osteoarthritis. Dr. McCarthy ... performed clinical stem cell therapy for 7 years. The ... a single injection of donor stem cells into one ... and inflammation in the treated joints. , Candidates ...
(Date:10/19/2014)... 20, 2014 OCTOBER 20-22, ... (ABIM). ABIM will take place at ... about ABIM 2014 is now available at ... representing companies and organizations from all over ... information on the latest products and developments ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... Norlight Telecommunications , a Brookfield, Wisconsin, ... Protocol service for small and medium-sized businesses in Wisconsin ... to offer the service to businesses in Minnesota, Michigan, ... marketing. , , IPLive will integrate voice, data ...
... Wisconsin-based Analogix joins French company to provide drug purification ... businesses Alliant Energy announces dip in ... furniture store selects Citrix IT tools ... purification products , Analogix , a maker of ...
... courtesy of Silicon Graphics Inc. Chippewa Valley, Wis. ... fastest supercomputer in about 129 days, and it was the ... SGI announced the completion of the $50 million project for ... after the space shuttle that crashed last year, runs on ...
Cached Biology Technology:Tech Digest: whats moving in the Midwest (11/1/04) 2SGIs Wisconsin branch builds fastest supercomputer yet in four months 2
Yields DNA greater than 50 kb in length from yeast, fungi, Gram neg. and Gram pos. bacteria...
Mouse monoclonal [1Q17] to TGE Virus peplomer ( Abpromise for all tested applications)....
Jak3 Antibody Ship: Hot Store: -20 C...
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Biology Products: