Navigation Links
Viral DNA sequence a possible trigger for breast cancer

A small sequence of DNA in the envelope (Env) protein of a mouse breast tumor virus (called MMTV) can transform breast cells into cancer cells, according to a study by Katz et al. in the February 7 issue of The Journal of Experimental Medicine. The ability of this motif to transform cells single-handedly suggests that viral infection may be an important and previously unrecognized trigger for breast cancer.

The DNA sequence in question is usually found in immune cells and helps trigger the activation and proliferation of the cells. These sequences have also been found in proteins from some other cancer-causing viruses such as Epstein Barr virus and Kaposi's sarcoma virus, but what role this sequence plays in cancer development has remained unexplored.

Katz and colleagues now show that this sequence is contained in the Env protein of MMTV and show that expression of Env in mouse breast cells transforms them. This study puts the spotlight on a potential new mechanism for virus-induced breast cell transformation, which has largely been attributed to the integration of viral DNA into locations that trigger the expression of host cancer-causing genes. An intriguing wrinkle to this study is the previously reported presence of sequences highly homologous to MMTV Env protein in the DNA of as many as 40% of human breast tumors, although a human homologue of MMTV has yet to be found.


'"/>

Source:Journal of Experimental Medecine


Page: 1

Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Viral protein influences key cell-signaling pathway
3. Viral protein helps infected T cells stick to uninfected cells
4. Viral fitness explains different resistance patterns to aids drugs
5. Viral genetic differences are possible key to HIV dementia
6. Viral hitchhiker inhibits Wolbachia bacterias ability to proliferate
7. Viral marker of human migration suspect
8. Viral protein is an effective preventative against infection
9. GATA: a graphic alignment tool for comparative sequence analysis
10. Found: Missing sequence of the human Y chromosome
11. Researchers uncover sequence of major rice pathogen
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Viral DNA sequence possible trigger for breast cancer

(Date:3/30/2015)... DUBLIN , Mar. 26, 2015 Research and ... addition of the "Global Gesture Recognition Market in ... The analysts forecast the Global Gesture Recognition market ... 12.8% over the period 2013-2018. Gesture recognition ... respond to different gestures of an individual. Gesture recognition ...
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ) ... Sensors Market Forecast and Opportunities 2020" report ... is projected to grow at a CAGR over ... industrial and healthcare sectors are the key application ... adoption of MEMS technology in sensors is growing ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... Lugano, Switzerland, 14 September 2012 -- Ahead of the ... be released during the ESMO 2012 Congress, over 1,600 ... 2012 at 9:00 (CEST) to anticipate the flavor of ... emerging strategies set to combat cancer, signposting future directions ...
... have developed a method that for the first time ... proteins and subsequently remove them in a repeatable cycle., ... this week in the journal Nature Methods , ... naturally formed proteins in order to create better antibiotics, ...
... ,Boston (Sept. 14, 2012) Eye injuries in ... as weapons, tactics, technology and strategies have evolved. ... cause extensive damage areas not protected by body armor. ... Institute, Massachusetts Eye and Ear will convene in Boston, ...
Cached Biology News:Noteworthy studies at the ESMO 2012 Congress 2Noteworthy studies at the ESMO 2012 Congress 3Noteworthy studies at the ESMO 2012 Congress 4Noteworthy studies at the ESMO 2012 Congress 5Noteworthy studies at the ESMO 2012 Congress 6Noteworthy studies at the ESMO 2012 Congress 7Chemists develop reversible method of tagging proteins 2Chemists develop reversible method of tagging proteins 3
(Date:4/17/2015)... Horsham, PA (PRWEB) April 17, 2015 ... Tech), a leader in regulatory data management, preparation, and ... announced today the availability of a new Lot Distribution ... that are required to remain compliant with the FDA’s ... Used by the FDA to monitor the volume and ...
(Date:4/17/2015)... SYDNEY , April 17, 2015  US-Australian drug ... signed a Memorandum of Understanding with the Feinstein ... New York to collaborate with ... cancers. The collaboration brings together the ... and clinical expertise of the Feinstein Institute in ...
(Date:4/16/2015)... 17, 2015 Spirax Sarco, the ... released their newly designed, state-of-the-art website in the ... website effectively promotes the Spirax Sarco brand, company ... information that a site visitor might be looking ... capabilities, industries serviced, the latest company news, careers, ...
(Date:4/16/2015)... 2015 Capillus, LLC announces plans ... network in Europe and Asia. The Miami-based medical ... Bermúdez, former Business Development Director of Svenson Group ... Mr. Bermúdez’s professional achievements include increasing the number ... also penetrating the Portuguese marketplace with centers in ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6Spirax Sarco website has a new look 2Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2
... 5 Experts from PAREXEL International Corporation (Nasdaq: ... services provider, will address important industry issues at ... being held from March 23 - 25, 2009 ... leaders will present on topics ranging from global ...
... BEACH, California and AMSTERDAM, March 5 ,Agendia, a ... the,appointment of Dr. Albert A. (Al) Luderer to ... Dr. Luderer has more than 30 years of ... therapeutic development. Currently, he,is the Chief Executive Officer ...
... WALTHAM, Mass., March 5 Proteon Therapeutics, Inc., announced ... Series B equity financing, led by MPM Capital on ... L.P. This announcement follows the initiation of a ... PRT-201, in patients with end stage renal disease undergoing ...
Cached Biology Technology:PAREXEL Experts to Present Leading Insights at Drug Information Association 21st Annual Euromeeting 2PAREXEL Experts to Present Leading Insights at Drug Information Association 21st Annual Euromeeting 3PAREXEL Experts to Present Leading Insights at Drug Information Association 21st Annual Euromeeting 4PAREXEL Experts to Present Leading Insights at Drug Information Association 21st Annual Euromeeting 5Agendia Appoints Seasoned Diagnostics Executive Albert A. Luderer to Supervisory Board 2Proteon Therapeutics Completes $38M Equity Financing; Initiates Phase 1/2 Clinical Study of PRT-201 in Hemodialysis Patients and Signs Option Agreement With Major Pharmaceutical Company 2
Rabbit polyclonal to XTP4 ( Abpromise for all tested applications). entrezGeneID: 84299 SwissProtID: Q9BRT3...
...
Rabbit polyclonal to XTP4 ( Abpromise for all tested applications). entrezGeneID: 84299 SwissProtID: Q9BRT3...
...
Biology Products: