Navigation Links
Variations in detoxifying genes linked to Lou Gehrig's disease

sible twofold increased risk for developing ALS in veterans of the Gulf War, indicating a war-related environmental exposure to organophosphates and sarin in genetically susceptible individuals as a possible cause. PON gene cluster variants have previously been associated with other neurodegenerative and vascular disorders, including Alzheimer's disease, Parkinson's disease, coronary artery disease and stroke.

Although the Northwestern DNA study samples were not analyzed for inclusion of Gulf War veterans, Siddique and co-researchers found significant evidence that gene variations (polymorphisms) on the chromosome region encompassing PON2-PON3 were strongly associated with sporadic ALS.

"Thus, single nucleotide polymorphism genotyping in the intergenic regions of the PON gene cluster, and replication, gene expression, gene-gene interaction and PON serum/enzymatic studies may help elucidate the complexity of PON cluster association with ALS," Siddique said.

Siddique hopes to study DNA samples from Gulf War veterans with increased incidence of sporadic ALS and has applied for their DNA from the Veterans Administration collection.


'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Inexpensive, mass-produced genes core of synthetic biology advances at UH
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. U-M scientists find genes that control growth of common skin cancer
5. Researchers find missing genes of ancient organism
6. Scientists document complex genomic events leading to the birth of new genes
7. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
8. Advances in the characterisation of the oyster mushroom genes
9. Researchers find new genes necessary to make embryo
10. Protein helps regulate the genes of embryonic stem cells
11. Compounds in plastic packaging act as environmental estrogens altering breast genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Variations detoxifying genes linked Lou Gehrig disease

(Date:4/2/2015)... , April 2, 2015 At its ... Salt Lake City , the American College of ... five new directors to its Board.  Members of the ... ACMG and for forming and advancing its policies and ... genetics profession. "It,s an eventful time in ...
(Date:4/1/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces the second shipment ... underway to early access pre-order customers. ... retail outlets including Walmart, Target, AT&T, Dunkin, Donuts, Stop ... accepted at all outlets and very easy to use. ...
(Date:3/31/2015)... March 31, 2015   Guidepoint , a leading ... the Post-Surgical Pain Management TRACKER, part of the ... trends in the medical device and therapeutics markets. The ... including treatment volumes, market share, and adoption rates across ... with joint surgery. The Post-Surgical Pain Management ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... development, it can regenerate itself to such an extent ... of the heart cells remain healthy. Dr. Jrg-Detlef Drenckhahn ... Berlin-Buch made this discovery together with colleagues from Australia. ... the healthy cells of the heart divide more frequently ...
... on other planets and in extreme environments on Earth ... initiative under a five-year grant from NASA,s Astrobiology Institute ... Christopher H. House, associate professor of geosciences, will lead ... characterize life, look for biological signatures in relevant ecosystems ...
... stick to surfaces and walk up walls has inspired many ... a gecko,s foot. The secret behind the gecko,s ability to ... micro-/nano-scale on the underside of the gecko,s foot. Because there ... tightly to the surface the gecko is walking on by ...
Cached Biology News:Repair in the developing heart 2Penn State receives new NASA astrobiology grant 2Penn State receives new NASA astrobiology grant 3
(Date:4/24/2015)... 24, 2015  Navitas Life Sciences is delighted to announce ... Clinical and Regulatory Services. Shalabh is a proven leader in ... CEO of Kinapse, as well as a Strategy consultant at ... - http://photos.prnewswire.com/prnh/20150423/201261LOGO ... "I am delighted to welcome Shalabh into this critical role ...
(Date:4/23/2015)... 2015 Athena San Diego, an organization ... women in San Diego’s technology and life science sectors, ... Awards at their Gala on April 30, 2015 from ... at http://athenasd.org/events/ , The Pinnacle Awards recognize ... Diego vision of fostering networking, risk taking and diversity ...
(Date:4/23/2015)... Washington, D.C. (PRWEB) April 23, 2015 ... Washington, D.C. region on April 4-17 as part ... visit marks the fourth group of biotechnology startups ... University of Nizhny Novgorod (UNN) and the University ... to deepen ties between their respective universities in ...
(Date:4/23/2015)... 2015  Cryoport, Inc. (OTCBB: CYRX) ("Company"), the ... the life sciences industry, today announced that the ... within the animal husbandry market by signing a ... the shipment of equine semen for artificial insemination ... Animal husbandry is a multi-billion dollar ...
Breaking Biology Technology:Shalabh Kumar Joins Navitas Life Sciences to Lead their Clinical and Regulatory Services Teams 2Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 3
... Call Scheduled for October 31, 2008 at 11:00 am ... plc,(Nasdaq: TRIB ), a leading developer and manufacturer ... will report,financial results for the third quarter of fiscal ... scheduled a conference call for that same,day, Friday, October ...
... Oct. 23 WaferGen Biosystems,Inc. (OTC Bulletin Board: ... cell biology and stem cell research systems,today announced ... will deliver a corporate presentation at the Seventh,Annual ... October 28-31, 2008,at the Palace Hotel in San ...
... SuperGen, Inc.,(Nasdaq: SUPG ), a ... of novel cancer therapies, today presented data ... additional posters, at the 20th,EORTC-NCI-AACR Symposium on ... MP-470, an orally bio-available multi-targeted,tyrosine kinase inhibitor, ...
Cached Biology Technology:Trinity Biotech plc to Announce Third Quarter 2008 Financial Results on October 31, 2008 2WaferGen to Present at the Seventh Annual BIO Investor Forum 2SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 2SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 3SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 4
...
... APAgene kits are designed to rapidly ... using our patented APA Technology. ... at an extraordinarily competitive price. All ... kit. The Locator Kit can be ...
Protein YIPF6 (YIP1 family member 6). [Source:Uniprot/SWISSPROT;Acc:Q96EC8] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
... to deparaffinize and perform Heat Induced Antigen ... sections mounted on glass microscope slides. Deparffinization ... the high temperature used in HIER (over ... paraffin by detergent. Formaldehyde fixation impairs or ...
Biology Products: