Navigation Links
Variations in detoxifying genes linked to Lou Gehrig's disease

sible twofold increased risk for developing ALS in veterans of the Gulf War, indicating a war-related environmental exposure to organophosphates and sarin in genetically susceptible individuals as a possible cause. PON gene cluster variants have previously been associated with other neurodegenerative and vascular disorders, including Alzheimer's disease, Parkinson's disease, coronary artery disease and stroke.

Although the Northwestern DNA study samples were not analyzed for inclusion of Gulf War veterans, Siddique and co-researchers found significant evidence that gene variations (polymorphisms) on the chromosome region encompassing PON2-PON3 were strongly associated with sporadic ALS.

"Thus, single nucleotide polymorphism genotyping in the intergenic regions of the PON gene cluster, and replication, gene expression, gene-gene interaction and PON serum/enzymatic studies may help elucidate the complexity of PON cluster association with ALS," Siddique said.

Siddique hopes to study DNA samples from Gulf War veterans with increased incidence of sporadic ALS and has applied for their DNA from the Veterans Administration collection.


'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Inexpensive, mass-produced genes core of synthetic biology advances at UH
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. U-M scientists find genes that control growth of common skin cancer
5. Researchers find missing genes of ancient organism
6. Scientists document complex genomic events leading to the birth of new genes
7. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
8. Advances in the characterisation of the oyster mushroom genes
9. Researchers find new genes necessary to make embryo
10. Protein helps regulate the genes of embryonic stem cells
11. Compounds in plastic packaging act as environmental estrogens altering breast genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Variations detoxifying genes linked Lou Gehrig disease

(Date:9/30/2014)... environment on Earth, but when the climate changes and ... limit. The amount of time needed to adjust to ... cope in the future, reveals a new study from ... scientific journal Proceedings of the Royal Society B ... levels of greenhouse gases in the atmosphere. The greenhouse ...
(Date:9/30/2014)... DURHAM, N.C. -- Pollution in urban and farm runoff ... a new study finds. , The study, published ... shows that nitrogen in the runoff ends up in ... tumors on the animals, eyes, flippers and internal organs. ... and the National Oceanic and Atmospheric Administration (NOAA) conducted ...
(Date:9/30/2014)... of Ludwig-Maximilians-Universitaet (LMU) in Munich report that a ... more sensitive to chemotherapeutic drugs. They have also ... new target for anti-tumor agents. , Researchers ... Stephan Sieber of the Technische Universitt Mnchen have ... potential new weapon in the fight against malignant ...
Breaking Biology News(10 mins):Shape up quickly -- applies to fish, too! 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Cancer therapy: Driving cancer cells to suicide 2
... Advancement of Science (AAAS) meeting in Washington, D.C., February ... from solar and renewable energy solutions to the latest ... president, will deliver the President,s Address at the opening ... Friday, February 18 ...
... affordable, high throughput DNA sequencing, coupled with improved bioinformatics ... the field of molecular plant breeding. Multidisciplinary breeding programs ... investigate genome-wide variations in DNA sequences and link them ... many genes, such as hybrid vigor. Furthermore, there has ...
... a method based on geographic positioning systems that allowed ... in a way similar to how geographers characterize mountain ... that reflects how "rugged" the surface of the tooth ... the shearing molars in insect eaters and omnivores to ...
Cached Biology News:Tip sheet: Caltech researchers presenting at AAAS 2Tip sheet: Caltech researchers presenting at AAAS 3UMass Amherst biologists use GPS to 'map' bats teeth to explore evolutionary adaptations to diet 2
(Date:9/30/2014)... Lyme Research Alliance (LRA), the ... at universities, today announced the awarding of seven grants ... and cure for Lyme and other tick-borne diseases. ... in its history—over 20 grant proposals—a 100 percent increase ... to receive so many solid applications from talented scientists ...
(Date:9/30/2014)... Windsor, CT (PRWEB) September 30, 2014 ... distributor of scientific research products, recently opened an ... its comprehensive cell culture product lines developed and ... through its online store include Biological Industries’ Nutristem® ... (hMSC) and human embryonic stem cell (hESC) culture. ...
(Date:9/30/2014)... 2014 UFP Technologies, a producer ... has recently introduced a custom insulated shipping container ... The new insulated shipper solves the issue of ... UFP Technologies’ BioShell is a universal storage container ... handling and shipping. The insulated shipper keeps frozen ...
(Date:9/30/2014)... Toronto, Ontario, Canada (PRWEB) September 30, 2014 ... requirements based on 500 square feet. per employee, which included ... different world back then.” says Jeff Howell, partner at ... tenant advisory firm in Toronto. “By the year 2000, ... We are now seeing that number come down to 175 ...
Breaking Biology Technology:Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3
... Telephone Corp. is opening a liason office with one ... campus. Hiroki Tanaka, vice president and general manager of ... seeking out opportunities for the company to expand further ... relationship during governor Jim Doyle's trade mission to Japan ...
... card American businesses have left to play if they ... and chief information officers must take the lead in ... Peters. , ,Peters spoke on Wednesday of the merits ... Wisconsin business executives during the Wisconsin Innovates Conference in ...
... Wis. Neurognostics Inc. said it has partnered ... combined functional magnetic resonance imaging software product. , ,"Both ... practice," said Doug Tucker, CEO of Neurognostics , ... collaborate on our efforts to develop clinically useful fMRI ...
Cached Biology Technology:Peters: Innovation the only edge that remains for American business 2
... EZ-Spread Plating Beads Sterile plating in ... glass rods and potentially hazardous ethanol flaming, ... choices of ready-to-use sterile packaging: dispenser bottle for ... plating, Fastest and easiest way to ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... a regulated environment, Pipette Tracker Pro ... that automates gravimetric pipette calibration and ... meets todays regulatory compliance requirements. Pipette ... that includes a full security implementation, ...
... the yolk protein Vtg in plasma from juvenile ... biomarker for endocrine disrupting chemicals (EDCs) with estrogenic ... an accepted screening test for the estrogenic effects ... EIA kit is a double-antibody immunometric (sandwich) EIA ...
Biology Products: