Navigation Links
Variations in detoxifying genes linked to Lou Gehrig's disease

Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), and possibly responsible for a reported twofold increased risk of ALS in Gulf War veterans.

These findings, from a study led Teepu Siddique, M.D., and colleagues at Northwestern University, open the door to investigating gene-environment interactions as a cause of ALS and other illnesses and to the development of molecular targets for specific treatments. The study was published in the August 22 online issue (available now) of the journal Neurology.

Siddique is Les Turner ALS Foundation/Herbert C. Wenske Professor, Davee Department of Neurology and Clinical Neurosciences, professor of cell and molecular biology and director of the Neuromuscular Disorders Program at Northwestern University Feinberg School of Medicine.

ALS is a complex neurodegenerative disorder of the motor neurons that results in muscle weakness, difficulty speaking, swallowing and breathing and eventual total paralysis and death generally within five years.

In 1993 Siddique and collaborators determined that mutations in a gene known as SOD1 account for 20 percent of familial, or inherited, ALS (2 percent of all cases of ALS). However, the cause of sporadic ALS is still unknown.

In earlier research Siddique and other researchers hypothesized that sporadic ALS is modulated by variations in multiple genes interacting with each other and environmental exposures.

The genes for human paraoxanases (PON 1, PON 2 and PON 3), which are located on chromosome 7q21.3, code for the production of detoxifying enzymes involved in the metabolism of a variety of drugs, organophosphate insecticides, such as parathion, diazinon and chlorpyrifos, and nerve gas agents such as sarin.

Previous research described a pos
'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Inexpensive, mass-produced genes core of synthetic biology advances at UH
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. U-M scientists find genes that control growth of common skin cancer
5. Researchers find missing genes of ancient organism
6. Scientists document complex genomic events leading to the birth of new genes
7. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
8. Advances in the characterisation of the oyster mushroom genes
9. Researchers find new genes necessary to make embryo
10. Protein helps regulate the genes of embryonic stem cells
11. Compounds in plastic packaging act as environmental estrogens altering breast genes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Variations detoxifying genes linked Lou Gehrig disease

(Date:8/26/2015)... , August 26, 2015 The ... and Five Factor), Application (Travel & Immigration, Government, Banking, ... Global Forecast to 2020", published by MarketsandMarkets, Multi-Factor Authentication ... 2020, growing at a CAGR of 17.7% between 2015 ... 82 F igures spread through 169 ...
(Date:8/20/2015)... Aug. 20, 2015 The wearable technology ... are active and healthy. However, wearable technology has ... environment to help improve diagnostic capabilities and therapeutic ... the Wearable Technologies Conference 2015 , where ... for wearables in healthcare.    "Over ...
(Date:8/18/2015)... PRINCETON, N.J. , Aug. 18, 2015 ... be a key contributor to the Submission ... hosted by IRISS, a non-profit forum. Dedicated to ... IRISS provides a neutral platform for industry, ... to share information and work towards a ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3
... by King,s College London has discovered 24 new genes that ... a major cause of blindness and visual impairment worldwide, ... in the journal Nature Genetics , reveal genetic causes ... or ways of preventing the condition in the future. ...
... track the movements of giant endangered sharks living in ... led by a researcher from Imperial College London, is ... are suitable for use in conservation work. Tourists ... underwater pictures of the spectacular and docile whale shark, ...
... DNA sequencing (NGS) technology has revolutionized biomedical research, ... used tool for a wide variety of research ... become a critical bottleneck for many researchers and ... Next-Generation DNA Sequencing Informatics provides a ...
Cached Biology News:New genes for short-sightedness identified 2Scientists using holiday snaps to identify whale sharks 2
(Date:9/4/2015)... 2015 Research and ... the "Biopreservation Market by Product, Biospecimen, Application ... report to their offering. The ... 3,731.03 Million by 2020 from USD 2,150.48 Million ... between 2015 and 2020. Biopreservation ensures ...
(Date:9/3/2015)... ... , ... The latest addition to the Mettler-Toledo PCE portfolio is ... in the pharmaceutical and healthcare industry can use the LSS to print track-and-trace labels ... Serialization Station can be fully integrated into the production line and is also available ...
(Date:9/3/2015)...  Vermillion, Inc. (NASDAQ: VRML ), a bio-analytical ... Herbert Fritsche , Ph.D., the Lab Director of ... of the 2015 Abbott Award, given by the International ... to the field of basic or clinical oncology. Dr. ... in Zakopane, Poland . Prior ...
(Date:9/3/2015)... -- According to a new market research ... Flash), GC, Other Components (Autosamplers, Detectors, Fraction Collectors), by ... & Global Forecasts to 2020", published by MarketsandMarkets, The ... Billion by 2020 from USD 7.062 Billion in 2015, ... tables and 36 figures spread through 277 Pages and ...
Breaking Biology Technology:Global Biopreservation Market 2015-2020 - Product, Biospecimen, Application and End User Analysis of the $3.73 Billion Industry 2Global Biopreservation Market 2015-2020 - Product, Biospecimen, Application and End User Analysis of the $3.73 Billion Industry 3Print and Verify Labels On The Production Line With New Label Serialization Stations 2Print and Verify Labels On The Production Line With New Label Serialization Stations 3Vermillion Announces Dr. Herbert Fritsche as Recipient of the 2015 Abbott Award from the International Society of Oncology and Biomarkers 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 3Chromatography Instruments Market Worth $ 9.223 Billion by 2020 4
... Research and,Engineering (IMRE), led by Professor Christian Joachim 1 ... first in the world to invent a,molecular gear of ... This achievement marks a radical shift in the scientific ... 2009 2 in Nature Materials 3 ...
... ... and control devices and level gauges, today announced that it has acquired certain assets ... liquid delivery solutions for the global semiconductor, solar, and electronics industries. Financial terms of ... ...
... Role of Chairman of the Board - , , ... INSM ), a biopharmaceutical company, today announced that Geoffrey Allan, ... Chairman of the Board of Directors, effective immediately, due to ... President, Chief Executive Officer and Chairman of the Board since ...
Cached Biology Technology:A*STAR scientists invent the world's only controllable molecule gear of minuscule size of 1.2nm 2Brooks Instrument Completes Acquisition of Celerity's Instrumentation Division 2Brooks Instrument Completes Acquisition of Celerity's Instrumentation Division 3Insmed CEO Resigns Due to Health Concerns 2Insmed CEO Resigns Due to Health Concerns 3