Navigation Links
VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells

Researchers at the Virginia Commonwealth University Massey Cancer Center have found a new signaling component that influences movement of human breast cancer cells toward epidermal growth factor.

In the August issue of the Journal of Biological Chemistry, researchers showed that epidermal growth factor, which plays a critical role in breast cancer progression, stimulates sphingosine kinases - SphK1 and SphK2 - a family of enzymes that forms the potent lipid mediator, sphingosine-1-phosphate, and that breast cancer cells are unable to move without these kinases.

"If we understood how tumor cells spread or metastasize, we would be able to design better tools to help treat cancers," said lead author Sarah Spiegel, Ph.D., chair and professor in the VCU Department of Biochemistry and co-leader of the Massey Cancer Center Cell Signaling program.

Spiegel, who is internationally recognized for her pioneering work on new lipid mediators that regulate cell growth and cell death, and her colleagues, first discovered the role of sphingosine-1-phosphate in cell growth regulation nearly a decade ago. While researchers know that SphK1 is stimulated by multiple growth factors, less is known about how SphK2 is regulated. Spiegel and her team are continuing this work to better understand the functions of these enzymes.

"Our work suggests that sphingosine kinases are potential new targets in cancer therapy," she said.


'"/>

Source:Virginia Commonwealth University


Page: 1

Related biology news :

1. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
2. VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum
3. Massey researchers induce cell death in leukemia
4. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
5. Jump-starting T Cells In Skin Cancer
6. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
7. Fox Chase Cancer Center scientists identify immune-system mutation
8. Breakthrough Microarray-based Technology for the Study of Cancer
9. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
10. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
11. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
Post Your Comments:
(Date:9/12/2014)... dendritic cells in human skin have assorted functions in ... researchers in the journal EMBO Molecular Medicine . ... composition of dendritic cells in psoriatic skin lesions might ... disease. , "We urgently need new ways to ... patients and reduce the incidence of known side effects ...
(Date:9/11/2014)... The classical treatise "Flora of Northumberland and Durham" ... Advanced Books platform as an example of ... create a new sort of resource and data re-use. ... botany of the region, which can be seen as ... on-line semantically enriched re-publication marries the meticulous detail ...
(Date:9/11/2014)... of DDT, American peregrine falcons ( Falco peregrines anatum ... to stop rearing young birds in captivity and placing ... published models that year in ESA,s journal ... falcon in California, with and without direct human intervention ... birds would continue to recover without captive rearing, though ...
Breaking Biology News(10 mins):Dendritic cells affect onset and progress of psoriasis 2Re-publication of 'Flora of Northumberland and Durham' (1831): A dramatic account of change 2Re-publication of 'Flora of Northumberland and Durham' (1831): A dramatic account of change 3Volunteer 'eyes on the skies' track peregrine falcon recovery in California 2Volunteer 'eyes on the skies' track peregrine falcon recovery in California 3Volunteer 'eyes on the skies' track peregrine falcon recovery in California 4Volunteer 'eyes on the skies' track peregrine falcon recovery in California 5
... Tom Corbett was honored today by the ... the Year Award in recognition of his leadership and commitment ... Pennsylvania . Corbett received the award ... Chicago, Ill. "This recognition from the ...
... R. Lewandowski, who opened with the line, "What if I ... with just refrigerator magnets and a laser pointer?", got raves ... team,s product, based on those common items, is a hand-held ... when digesting red blood cells. The Rapid Assessment of ...
... by Cornell University,s Creative Machines Lab has created a computer ... their squishy, muscle-like features in order to teach themselves to ... how nature builds complex animals from jellyfish to jaguars. ... evolve a diverse series of gaits and gallops. The ...
Cached Biology News:Governor Corbett Presented 2013 Biotechnology Industry Organization Governor of the Year Award 2Governor Corbett Presented 2013 Biotechnology Industry Organization Governor of the Year Award 3Hand-held device cheaply, quickly diagnosis malaria 2Hand-held device cheaply, quickly diagnosis malaria 3
(Date:9/12/2014)... Nasa Ames Research Base, Mountain View, CA (PRWEB) September ... announces the launch of its fundraising campaign on Indiegogo. ... producer Matt Rutherford, features Stephen Hawking, Buzz Aldrin, Shimon ... , Exponential technology is changing the world and there’s ... students how to harness it to help change the ...
(Date:9/11/2014)... it has uncovered the secret behind the unusual ... metal dichalcogenide (TMDC) materials, the two-dimensional semiconductors that ... , Using two-photon excitation spectroscopy, the researchers ... most promising of 2D materials, and found evidence ... energy states in which single photons can be ...
(Date:9/11/2014)... SARASOTA, Fla. , Sept. 11, 2014 ... novel anti-infective pharmaceuticals, announced today that the ... issued a ,Notice of Allowance, for patent ... Their Uses,.  The ,486 patent application relates ... act through gene-silencing and can be designed ...
(Date:9/11/2014)... TORONTO , Sept. 11, 2014 /PRNewswire/ - Portage ... Canadian Securities Exchange: PBT.U), announces that it intends ... to US$ 2 million for funding its preclinical ... Holding Company Limited, ("Biohaven"). The Company ... up to 20 million common shares at a ...
Breaking Biology Technology:Documentary Film that Follows Singularity University Students as They Change the World Launches its IndieGoGo Fundraising Campaign 2Excitonic dark states shed light on TMDC atomic layers 2Excitonic dark states shed light on TMDC atomic layers 3Lakewood-Amedex Receives Notice Of Allowance From The United States Patent and Trademark Office (USPTO) For A New Patent Covering Its nanoRNA Gene-Silencing Technology 2Lakewood-Amedex Receives Notice Of Allowance From The United States Patent and Trademark Office (USPTO) For A New Patent Covering Its nanoRNA Gene-Silencing Technology 3Portage Announces Proposed Private Placement 2Portage Announces Proposed Private Placement 3Portage Announces Proposed Private Placement 4
... Halozyme Therapeutics,Inc. (Nasdaq: HALO ), a biopharmaceutical ... that it will present at two investor conferences in ... Summit to be held at the,Mark Hopkins InterContinental Hotel ... a.m. Pacific Time (12:30 p.m. Eastern Time); and, ...
... Masimo (Nasdaq:,MASI), the inventor of Pulse CO-Oximetry ... purchasing the Masimo Radical-7, the company,s flagship,product, ... as a standard feature., Conventional pulse ... drops in oxygen saturation values, known as ...
... Washington, DC Widespread use of nanoscale silver ... benefits against the possibility of significant environmental risk, ... this emerging technology, according to a new report ... (PEN). , But existing information about the ...
Cached Biology Technology:Halozyme Therapeutics to Present at Upcoming Investor Conferences 2Masimo Announces Desaturation Index 3D Alarm as Standard Feature in All Radical-7 Pulse CO-Oximetry Devices 2Masimo Announces Desaturation Index 3D Alarm as Standard Feature in All Radical-7 Pulse CO-Oximetry Devices 3Nanoscale silver: No silver lining? 2Nanoscale silver: No silver lining? 3
... the MSn performance of the LTQ linear ... generate extensive structural information for the most ... Multiple dissociation techniques (PQD, ETD, CID) , ... , Fast polarity switching for high-sensitivity analysis ...
Request Info...
The Synergy HT utilizes a unique dual-optics design combined with monochromator wavelength selection to provide uncompromised performance in absorbance, fluorescence and luminescence reading modes. ...
... SYBR Green I nucleic acid gel stain ... that has bright fluorescence when bound to dsDNA ... for detecting dsDNA in gels using laser scanners ... acid stain has also found uses in capillary ...
Biology Products: