Navigation Links
Used in a new way, RNA interference permanently silences key breast cancer gene

In laboratory mouse experiments, researchers at The University of Texas M. D. Anderson Cancer Center have developed a way to use RNA interference (RNAi) so that it permanently hampers breast cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human breast tumors, thus reducing the cancer's ability to become invasive.

The study, presented at the annual meeting of the American Association for Cancer Research (AACR), used a modified form of RNAi to silence STAT3 in a permanent way. Typically, only a transient effect is achieved with RNAi before the tiny bits of genetic material are become inactive as the cell population continues to expand.

"We are a long way from using this technique in patients, but this study shows that that it may be possible to use RNAi in more than just experiments that silence genes temporarily," says the study's principal investigator, Ralph Arlinghaus, Ph.D., a professor and chair of the Department of Molecular Pathology. Details of the study appeared in the April 1 2005 issue of the journal Cancer Research.

"The technique is also providing some valuable insights into the role of STAT3 and its downstream targets," adds Arlinghaus, who also will discuss the work in a mini symposium at the AACR meeting.

RNAi has been employed as a laboratory tool to knock down expression of genes in a variety of cells and organisms. It works by introducing a small double-stranded RNA (RNAi) that specifically targets a gene's product, its messenger RNA. This action then blocks translation and production of the protein that the gene encodes.

In this study, the researchers used a lentivirus (a type of retrovirus) to deliver a specifically designed long-acting small interfering RNA (termed a short hairpin RNA, shRNA) for mouse STAT3 into a mouse breast cancer cell line. They chose STAT3 because when activated, it is involved in the formation of multiple types of tumors, including
'"/>

Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2

Related biology news :

1. Scientists identify genetic pathways essential to RNA interference
2. Silence the gene, save the cell: RNA interference as promising therapy for ALS
3. Scientists identify genetic pathways essential to RNA interference
4. RNA interference stops colon cancer spread in mice
5. Cocaine high caused by interference in neuronal receiving stations
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Interfering RNA silences genes in slippery immune cells
8. Researchers find protein that silences genes
9. MIT: Pulsing light silences overactive neurons
10. Viral DNA sequence a possible trigger for breast cancer
11. Biomarkers isolated from saliva successfully predict oral and breast cancer
Post Your Comments:
(Date:12/4/2014)... , Dec. 3, 2014  Crossmatch™, a ... announced that its DigitalPersona ® Pro Enterprise ... have been deployed throughout First Bank branch locations ... South Carolina and Virginia. First Bank, ... Southern Pines, North Carolina , selected ...
(Date:11/21/2014)... MOUNTAIN VIEW, Calif. , Nov. 20, 2014 /PRNewswire/ ... for higher driver efficiency are piloting the North American ... the number of accidents growing, gesture recognition systems that ... will make a mark in the industry. ... of the Automotive Gesture Recognition Market in ...
(Date:11/18/2014)... BETHESDA, Md. , Nov. 17, 2014 The ... European and U.S. regulatory agencies will speak and at least ... Quality Metrics Conference at the Omni Shoreham Hotel in ... is pleased once again to have significant support from the ... and Europe in our effort to ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... press release is available in French . ... Laval researchers and their colleagues from the Canadian Forest Service ... and fir has remained very much the same for over ... between today,s conifers and fossils dating back to the days ...
... Rochelle, NY, December 13A leading scientific society of university ... research in the sciences and technologies of environmental protection, ... (AEESP) , has selected the peer-reviewed journal ... Environmental Engineering Science is read around the ...
... animal cell is like a small city, with factoriescalled ... life functions. A network of intercellular "highways," called microtubules, ... speedily about the cell to keep this vital machinery ... Proceedings of the National Academy of Sciences ...
Cached Biology News:Your Christmas tree and its genome have remained very much the same over the last 100 million years 2Association of Environmental Engineering and Science Professors name Environmental Engineering Science as its official journal 2Study sheds light on how cells transport materials along crowded intercellular 'highways' 2Study sheds light on how cells transport materials along crowded intercellular 'highways' 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... - Mercedes Walton, Chairman and CEO of Cryo-Cell International ... Fla., March 17 As the CEO of Cryo-Cell ... bank, Mercedes Walton has been an active participant in ... She has seen first-hand the changes that have taken ...
... Spiral Biotech, an Advanced Instruments company, will ... -- which delivers faster cycle times, a ... processing speed and efficiency in microbiology laboratories -- ... Meeting in May, 2009."The introduction of the new ...
... Ferring Pharmaceuticals Inc., a specialty pharmaceutical company, ... to Senior Vice President of the Ferring International ... for Ferring Pharmaceuticals Inc. Dr. Korner was ... Orthopaedics, Urology, and Gastroenterology therapeutic areas, as well ...
Cached Biology Technology:Stem Cell Industry Insider Mercedes Walton Discusses President Obama's Stem Cell Executive Order 2Stem Cell Industry Insider Mercedes Walton Discusses President Obama's Stem Cell Executive Order 3Spiral Biotech to Introduce New Autoplate Spiral Plating System at ASM General Meeting in May 2Spiral Biotech to Introduce New Autoplate Spiral Plating System at ASM General Meeting in May 3Dr. Paul Korner Promoted to Senior Vice President of Ferring International PharmaScience Center U.S. 2
...
Whole blood is collected from healthy guinea pigs of either sex from US source which are free of visible diseases at time of blood collection. Hemolytic titer: CH50 = 435 units...
... l-[35S]in vitro cell labeling mix, ... *Aqueous solution stabilized with 0.1% ... pyridine 3,4-dicarboxylic acid. *Amino acid ... labeling containing l-[35S]Methionine and l-[35S]Cysteine. ...
...
Biology Products: