Navigation Links
Unusual mechanism keeps repair protein accurate

o had a predicted structure that should allow it to "dock" with other proteins. "This suggests that this protein may do more than just fix DNA damage," Suo says.

Region two held the surprise. It is called the proline-rich domain because it has high levels of the amino acid proline.

"There was no known function for a structure like the proline-rich domain, so we at first thought it did nothing more than connect the docking region of the protein with regions three and four," Suo says.

"Then by accident we learned that this was not just a structural connection, but that it is critical to the protein's ability to replicate DNA with very few mistakes."

For this study, Suo and his colleagues wanted to learn how efficiently the new protein made new DNA. But the researchers initially considered the protein too large and difficult to produce in the laboratory. So instead of making the entire protein, the researchers made only the part that does the repair work, regions three and four.

When they tested this short version of the protein, however, they found that it made up to a 100 times more mistakes than did the similar repair protein, DNA polymerase beta.

"That error rate is too high," Suo says. "If the entire repair protein produced that many errors, it would cause more problems than it would fix."

Next, the researchers made the entire protein and found that it could repair DNA as accurately as the comparison protein.

Last, they tested a version of the protein that lacked the docking region. This shortened molecule also accurately made DNA.

"To find that the proline-rich domain was responsible for this repair protein's high fidelity came as a complete surprise," Suo says.

Presently the scientists are studying the three-dimensional structure of the entire protein to learn how the presence of a proline-rich region influences the ability of the protein to accurately make DNA.
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Unusual antibiotics show promise against deadly superbugs
2. A new mechanism of regulating RNA degradation
3. Plants, animals share molecular growth mechanisms
4. PET/MRI scans may help unravel mechanisms of prenatal drug damage
5. Researchers discover molecular mechanism that desensitizes us to cold
6. Chemists identify immune system mechanism for methamphetamine binges
7. Key mechanism in genetic inheritance during cell division identified
8. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
9. Mouse gene shows new mechanism behind cardiac infarction in man
10. UCSD research reveals mechanism involved with type of fatal epilepsy
11. Ancient immune defense mechanism is no match for HIV-1
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Unusual mechanism keeps repair protein accurate

(Date:10/14/2014)... fish oil supplements, rich in omega-3 fatty acids, do not ... which the heart can beat as fast as 150 beats ... the Montreal Heart Institute were published in the Journal ... , For the trial, 337 patients with atrial fibrillation not ... of fish oil a day or to placebo for up ...
(Date:10/14/2014)... led by the Chinese Academy of Agricultural Sciences in ... a brief genomic history of tomato breeding, based on ... The C.M. Rick Tomato Genetics Resource Center at UC ... providing seed of both cultivated tomato varieties and related ... first tomato genome sequence completed just two years ago, ...
(Date:10/14/2014)... 14 October 2014 – Researchers from Stanford University School ... mechanism used by cells and the activation of muscle ... blocks" and generate energy during times of nutrient deprivation. ... that when this protective mechanism is operational it also ... "Our study reveals that when stem cells emerge from ...
Breaking Biology News(10 mins):Autophagy helps fast track stem cell activation 2
... honour, the American entertainer Jack Benny once said, "I don,t ... deserve that either." Unfortunately, Benny was not alone in ... associated with significant discomfort and simple activities such as going ... A variety of treatments are available, usually involving a combination ...
... of a new scientific study from Oxford Brookes University show ... short-term total energy intake in men and women. ... Jeya Henry of the Functional Food Centre at Oxford Brookes ... compensation effect of liquid calories on short-term energy consumption, by ...
... the Entomological Society of America, will feature two plenary ... 12-15, 2010. Christopher Marley, an author and insect ... "insect-phobe" into an aficionado during a speech called "The ... CA in the late 1960,s, where he had a ...
Cached Biology News:A dog's life -- physiotherapy for arthritic pets 2Research shows gender difference in energy compensation effect 2Christopher Marley and James McWilliams to give plenary speeches at Entomology 2010 2
(Date:10/19/2014)... The report "Unmanned Ground Vehicle ... Technology, Payload, Type & by Geography - Forecasts ... unmanned ground vehicle market into various sub segments ... sizes. The report also identifies the factors driving ... along with the adoption trends. , The unmanned ...
(Date:10/18/2014)... The “Human Insulin Market- by Product ... Modern Human Insulin (Rapid Acting, Long Acting, Premixed)], ... Others) - Forecast to 2018” provides a detailed ... current market trends, and strategies impacting the global ... forecasts of the revenue and share analysis. , ...
(Date:10/18/2014)... October 18, 2014 The report ... Trends and Forecasts to 2019", analyzes the global ... order to understand the industry details such as ... across various geographic regions. , Browse 81 Market ... Slides and in-depth TOC on “1,6-Hexanediol Market by ...
(Date:10/18/2014)... 2014 The Asia-Pacific hardware encryption display ... Asia-Pacific with analysis and forecast of revenue. This market ... to reach $51,362.6 million by 2018, at a CAGR ... the TOC of the Asia-Pacific hardware encryption market report, ... This also provides a glimpse of the segmentation of ...
Breaking Biology Technology:Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 51,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3
... of mobile devices that run longer on lighter, slimmer ... University of Illinois engineers have developed a form ... 100 times less energy than similar available memory. The ... life between charges. Led by electrical and computer ...
... LLC, a Honeywell (NYSE: HON ) company, announced ... (Malaysia) Sdn. Bhd. to perform the engineering design for a ... to convert palm biomass to renewable heat and electricity. ... late 2011 and completed in early 2013, will be Malaysia,s ...
... Volcano Corporation (Nasdaq: VOLC ), a ... therapy guidance tools designed to enhance the treatment of ... will be participating in the Roth 23rd Annual Orange ... The presentation by David Sheehan, President, IVUS and ...
Cached Biology Technology:New technology would dramatically extend battery life for mobile devices 2New technology would dramatically extend battery life for mobile devices 3Honeywell's Envergent Technologies Selected by Malaysian Company for Renewable Energy Project 2Honeywell's Envergent Technologies Selected by Malaysian Company for Renewable Energy Project 3
...
Anti-ZFP-38/RU49 Family: Zinc Finger Peptide Sequence: SVKVEDKDFPSTCSKK...
...
... plant total protein western blot ... screening tissue specific protein expression ... total protein is included in ... control for comparison between different ...
Biology Products: