Navigation Links
Tumor cells that border normal tissue are told to leave

The thin, single-cell boundary where a tumor meets normal tissue is the most dangerous part of a cancer according to a new study by scientists at Washington University School of Medicine in St. Louis. The researchers found that tumor cells bordering normal tissue receive signals that tell them to wander away from the tumor, allowing the cancer cells to establish deadly metastatic tumors elsewhere in the body.

The researchers say their discovery demonstrates the importance of the tumor's environment and shows more precisely how the metastatic process occurs and might be stopped. Their study appears in the January 10 issue of Developmental Cell.

"What actually kills in cancer is not the primary tumor--it's metastasis," says senior author Ross L. Cagan, Ph.D., associate professor of molecular biology and pharmacology and a researcher with the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. "You can't study that in a laboratory dish. You have to look at the tumor cells in their natural environment--surrounded by normal tissues."

To do this, the research team created tumors in fruit fly eyes and wings that permitted them to study the behavior of individual tumor cells.

"We found that the tumor cells in direct contact with normal cells had a different behavior than cells further inside the tumor," says lead author Marcos Vidal, Ph.D., research associate in molecular biology and pharmacology. "They were exclusively the ones that tended to leave the tissue."

The tumors were generated by turning off an inhibitor of a major oncogene called Src (pronounced sarc), making the tumor cells high in Src oncogene activity. (An oncogene is a gene that increases the malignancy of a tumor cell.) This particular genetic change is common in human breast tumors.

Boundary tumor cells were shown to lose surface proteins that attach them to other cells and stabilize their position within tissues. T
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Missing Receptor Molecule Causes Tumor Growth
2. Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors
3. New Therapeutic Target Identified In Inherited Brain Tumor Disorder
4. Tumor wizardry wards off attacks from the immune system
5. Tumor cells evade death through autophagy
6. Tumor-suppressor gene is critical for placenta development
7. Wisconsin scientists grow critical nerve cells
8. Spleen may be source of versatile stem cells
9. Researchers discover way to make cells in the eye sensitive to light
10. Priming embryonic stem cells to fulfill their promise
11. Lack of enzyme turns fat cells into fat burners
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tumor cells that border normal tissue are told leave

(Date:8/28/2014)... MARC (Maximizing Access to Research Careers) Program has ... Society of America,s 27th Annual Mouse Molecular Genetics ... in Pacific Grove, California. These awards are ... doctorates and scientists from underrepresented groups into the ... encourage the participation of young scientists at the ...
(Date:8/28/2014)... delivering compounds that could positively impact the ... be possible, thanks to researchers in Penn ... vaginal suppository made from the seaweed-derived food ... drug Tenofovir provides a woman-initiated, drug-delivery vehicle ... sexually transmitted infections during unprotected heterosexual intercourse, ...
(Date:8/28/2014)... Dyslexia, the most commonly diagnosed learning disability in ... that occurs when the regions of the brain ... The use of non-invasive functional neuroimaging tools has ... dyslexia. However, most prior work has focused on ... a gap in our understanding of how multiple ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Dyslexic readers have disrupted network connections in the brain 2
... , NEW YORK, Sept. 8 Reportlinker.com announces ... catalogue. , , Carbon Dioxide ... , , This report analyzes the ... by the following segments: End-tidal Carbon Dioxide (EtCO2) Monitors, and ...
... , , REDWOOD CITY, Calif., ... authentication solutions, today announced that NCR Corporation is now ... on NCR,s next-generation integrated point-of-sale (POS) workstation, the NCR RealPOS ... which is embedded in the top of the NCR RealPOS 70 ...
... MADISON, WI, SEPTEMBER 21, 2009 -- In looking ... carefully examining the role of nitrogen fixation in delivering ... long, nitrogen fixation of the soil has involved a ... thus tying the agricultural industry to the availability and ...
Cached Biology News:Reportlinker Adds Carbon Dioxide Monitors Report 2Reportlinker Adds Carbon Dioxide Monitors Report 3Reportlinker Adds Carbon Dioxide Monitors Report 4Reportlinker Adds Carbon Dioxide Monitors Report 5Reportlinker Adds Carbon Dioxide Monitors Report 6Reportlinker Adds Carbon Dioxide Monitors Report 7Reportlinker Adds Carbon Dioxide Monitors Report 8Reportlinker Adds Carbon Dioxide Monitors Report 9NCR Embeds DigitalPersona U.are.U(R) 4500HD Fingerprint Sensor in New NCR RealPOS(TM) 70XRT Point-of-Sale Workstations 2Is nitrogen the new carbon? 2
(Date:8/28/2014)... (PRWEB) August 28, 2014 Best Sanitizers, ... for the food processing industry, is asking industry professionals ... side comparison of the E2 soap they’re currently using ... Foam Soap . Hand hygiene is critical to ... food processing environment. Six key criteria are identified to ...
(Date:8/28/2014)... devices in spintronics, an electronic which is not ... also on their spin and the spin-related magnetism. ... magnetic signals and vice versa. Recently, the research ... of Physics at Johannes Gutenberg University Mainz in ... Japan, has for the first time realised a ...
(Date:8/28/2014)... ATLANTA , Aug. 28, 2014   SunTrust ... of three industry veterans to its equity research ... "Our ongoing expansion in equity research demonstrates ... with unique insights to enhance their investment decision ... Equities at STRH.  "We continue to make significant ...
(Date:8/28/2014)... Washington, USA (PRWEB) August 27, 2014 ... next month for SPIE Laser Damage 2014 ... optical materials for high-power lasers will run 14-17 September. ... society for optics and photonics . , The premier ... for understanding laser damage to optical materials will engage ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3
... Stock Exchange Symbol: MS, EDMONTON, June 12 /PRNewswire-FirstCall/ - BioMS ... sclerosis (MS), today,announced that Mr. Kevin Giese, President and CEO, will ... San Diego,California., WHEN: ... WHERE: ...
... Raptor Pharmaceuticals Corp.,(OTC Bulletin Board: RPTP), today announced ... development subsidiary, will,present at the 2008 BIO International Convention ... Convention Center in San Diego, CA., Mr. Daley,s ... 2008 at 1:15p.m. (PT) in room 4 of the ...
... Calif., June 11 Jazz,Pharmaceuticals, Inc. (Nasdaq: ... shelf registration statement with the U.S. Securities and,Exchange ... registration,statement has been declared effective by the SEC, ... to an aggregate of $100 million of its,common ...
Cached Biology Technology:BioMS Medical to present at 2008 BIO International Convention 2Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 2Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 3Raptor Pharmaceuticals Corp. To Present at BIO 2008 International Convention 4Jazz Pharmaceuticals Files Form S-3 Registration Statements 2Jazz Pharmaceuticals Files Form S-3 Registration Statements 3
... is a new technology for sensitive ... small amounts of DNA (5). This ... to modify the DNA, followed by ... to distinguish methylated from unmethylated DNA. ...
... used for the synthesis of 5' capped ... Substitution of cap analog for a large ... vitro transcription reaction results in the incorporation ... fraction of the transcripts. Capped mRNAs are ...
... Incubator/Shaker HT is designed for ... Incubator/Shaker HT is ideal for ... and primer extension assays. The ... as a one-cabinet model, allowing ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. It can incubate up to ...
Biology Products: