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The molecular mechanism of a diabetes vaccine revealed

sually make which lead to autoimmune disease. This double action of the peptide weakens the damaging activities of the immune response further. The scientists also showed that in order to activate this response, p277 must be bound to the receptor TLR-2, which is found on the cell walls of the regulatory T cells.

"These findings are important, as it means that by identifying the molecular activity of p277 with such precision, we can copy nature's own system in regulating the immune system and therefore, help to boost the immune system in preventing the destruction of insulin-producing pancreatic cells," says Cohen.

Postdoctoral fellow Dr. Alexandra Zanin-Zhorov spearheaded the project; the other scientists participating in this study were: the late Prof. Ofer Lider, Dr. LioraCahalon, postdoctoral fellow Guy Tal, and Raanan Margalit.


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Source:American Committee for the Weizmann Institute of Science


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