Navigation Links
The molecular mechanism of a diabetes vaccine revealed

A team of researchers led by Prof. Irun Cohen of the Weizmann Institute of ScienceImmunology Department has revealed the molecular mechanism of a vaccine for Type 1 diabetes. The new findings should help amplify the effectiveness of the vaccine, which is currently in advanced stages of clinical trials. Type 1 diabetes is an autoimmune disorder in which the immune system mistakenly attacks the body's own insulin-producing pancreatic cells, reducing and ultimately eliminating the production of insulin ?a hormone needed to convert sugar, starches, and other foods into energy.

Several years ago, Prof. Cohen and colleagues developed a vaccine that arrests the progression of Type 1 diabetes in laboratory animals. They had discovered that a particular protein called HSP60, or even only a small particular fragment of it ?the peptide designated p277 ?is able to shut down the autoimmune response causing this disorder. The vaccine is currently being tested in clinical trials in Europe and the United States, but its precise mechanism has until now been unknown.

"When translating these findings into a practical vaccine, we knew enough about the mechanism to understand that this protein is able to cause a decrease in the immune response, but how it actually works eluded us," says Cohen. In a paper published in the Journal of Clinical Investigation, the scientists have managed to identify the exact immune cells that p277 acts upon and its mechanism of action.

Autoimmune diseases occur when certain T cells in the immune system attack the body's own cells and tissues. The scientists discovered that p277 directs the activity of the immune system in two ways. First, the p277 peptide steps up the activities of a different type of T cell that regulates the amount of potentially harmful T cells available. In addition, T cells treated with p277 cause the delinquent T cells to secrete anti-inflammatory substances instead of the inflammation-causing ones that they u
'"/>

Source:American Committee for the Weizmann Institute of Science


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Source of molecular triggers in cutaneous T cell lymphoma identified
3. Plants, animals share molecular growth mechanisms
4. NYU researchers simulate molecular biological clock
5. Scientists reveal molecular secrets of the malaria parasite
6. Scientists identify molecular events that drive cell senescence
7. Researchers discover molecular mechanism that desensitizes us to cold
8. Findings have implications for tracking disease, drugs at the molecular level
9. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
10. At the molecular level, the predator is the prey
11. By creating molecular bridge, scientists change function of a protein
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The molecular mechanism diabetes vaccine revealed

(Date:10/28/2014)... of Health (NIH) announced awards to expand the ... National Center for Advancing Translational Sciences (ORDR-NCATS) collaborative ... the network, physician scientists at 22 consortia will ... clinical research and investigate new treatments for patients ... by $29 million in fiscal 2014 funding from ...
(Date:10/27/2014)... researchers have delivered a scientific one-two punch with a ... self-assemble via their sticky ends. , Collagen is the ... bone and the fibrous tissues that support cells and ... better synthetic collagen for tissue engineering and cosmetic and ... has been studying synthetic collagen for a decade, teasing ...
(Date:10/27/2014)... 27, 2014) — Recent breakthroughs may pave the ... infected by parasitic helminths. These flatworms, including tapeworms ... and blood flukes (schistosomes), infect more than 300 ... life years lost due to chronic illness and ... , professor of microbiology, immunology, and tropical medicine, ...
Breaking Biology News(10 mins):NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 2NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 3'Sticky' ends start synthetic collagen growth 2'Sticky' ends start synthetic collagen growth 3GW researcher adapting breakthrough technologies to combat parasitic worm infections 2
... of the brain are over-stimulated and this leads to ... this process was finally shown last year to be ... stroke. But very few targets for drugs to block ... detailed study, researchers have discovered a previously missing link ...
... an evolutionary geneticist at Fred Hutchinson Cancer Research Center who ... with opposing functions that drives evolutionary change has been ... is among 27 of the nation,s top biomedical scientists to ... more than 1,100 applicants. , "HHMI has a very ...
... Solanaceaea flowering plant family with some species producing foods ... effect against Parkinson,s disease. The study appearing today in ... American Neurological Association and Child Neurology Society, suggests that ... nicotine, such as peppers and tomatoes, may reduce risk ...
Cached Biology News:Researchers discover a missing link in signals contributing to neurodegeneration 2Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator 2Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator 3Could eating peppers prevent Parkinson's? 2
(Date:10/30/2014)... The severe flooding that devastated a wide swath of ... the bridges, roads and other infrastructure had been upgraded ... University of Colorado Denver. , "People need to understand ... PhD, associate professor of structural engineering at the CU ... author the study. "There is an assumption that a ...
(Date:10/27/2014)... Kalorama Information says that PCR is demonstrating ... the United States and is the ... said the FDA,s Emergency Use Authorization (EUA) to authorize the ... detection of the Ebola virus was an indication that ... the IVD industry and its biennial survey on diagnostics ...
(Date:10/27/2014)... 2014 Pressure BioSciences, Inc. (OTCQB: PBIO) ... the development and sale of high pressure-based sample ... today announced that Professor Ruedi Aebersold ... reproducible, and robust method to allow – for ... on small needle biopsy samples by mass spectrometry ...
(Date:10/25/2014)... The report “Adipic Acid Market by ... Global Trends & Forecast to 2019” report analyzes ... drivers, opportunities, and trends in different regions. , ... spread through 217 slides and in-depth TOC on ... to 2019”., http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , Early buyers will ...
Breaking Biology Technology:CU Denver study says upgrading infrastructure could reduce flood damage 2Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 4Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 5Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4
... that going from a positive to a negative is a ... scientists from the National Institute of Standards and Technology (NIST) ... extended the reach of their novel microfluidic system for analyzing ... how the system, meant to analyze real-world, crude mixtures such ...
... help resolve the public debate over America,s future light source ... compact fluorescent lamp. It could be neither. ... new breed of light emitting diode, or LED, that conjures ... an article in the current online issue of the journal ...
... Ariz., Aug. 31, 2011 SynCardia Systems, Inc. ( www.syncardia.com ... today that it has launched company pages on Facebook ... to educate a larger audience about the world,s only FDA, ... have been more than 950 implants of the Total Artificial ...
Cached Biology Technology:Researchers expand capabilities of miniature analyzer for complex samples 2Manufacturing method paves way for commercially viable quantum dot-based LEDs 2Manufacturing method paves way for commercially viable quantum dot-based LEDs 3SynCardia Goes Social on Facebook, Twitter and LinkedIn 2SynCardia Goes Social on Facebook, Twitter and LinkedIn 3SynCardia Goes Social on Facebook, Twitter and LinkedIn 4
... 2 real-time PCR detection system uses a ... (470-505 nm) and two photomultiplier tubes for ... Opticon 2 system is built on an ... thermal gradient feature. This item includes the ...
Fingerprinting II Informatix cluster analysis is an optional module that adds dendrogram and phylogenetic tree construction, cluster and group significance, and congruence of techniques functions to ...
... Fingerprinting II Informatix ... an optional module ... component analysis, multidimensional ... and MANOVA, and ...
... Cell Lines ,High Quality, Functionally-Validated, Ion Channel ... known for having a critical role in ... a key function in pain, CNS and ... have been investigated in therapeutic areas, such ...
Biology Products: