Navigation Links
Texas scientists discover how a hepatitis C protein promotes liver cancer

Scientists at the University of Texas Medical Branch at Galveston (UTMB) have identified a key biochemical connection between the hepatitis C virus and liver cancer.

The molecular mechanism is similar to the one that links the human papilloma virus (HPV), the cause of genital warts, and cervical cancer, according to Dr. Stanley M. Lemon, the senior author of a paper on the discovery that will be published this week in the online early edition of the Proceedings of the National Academy of Sciences.

"What we've found is that one of the hepatitis C virus proteins targets a cell protein that is crucial for suppressing the development of tumors, interfering with its ability to control cell proliferation," Lemon said. "By knocking out this 'tumor suppressor' and promoting the proliferation of liver cells, this viral protein is setting up the liver for cancer."

According to the federal Centers for Disease Control and Prevention, about 85 percent of liver cancer cases in the United States occur in people infected by the hepatitis C virus. Approximately 200 million people worldwide suffer from chronic hepatitis C, which can persist in the body for decades after an initial infection, often causing so much liver damage that a transplant may be a patient's only chance for survival. The most effective treatment available, interferon therapy, works only about half the time and often causes debilitating side effects. Those who fail treatment are at risk for fatal cirrhosis or developing liver cancer.

Researchers have known for a long time that hepatitis C virus infection can lead to liver cancer. But how the virus goes about this has been unclear.

The UTMB group discovered that the tumor-suppressing retinoblastoma protein is present at markedly reduced levels in cells containing a hepatitis C virus "replicon," a large piece of hepatitis C genetic material that is able to reproduce itself in cultured cells and also able to produce proteins m
'"/>

Source:University of Texas Medical Branch at Galveston


Page: 1 2

Related biology news :

1. Sugar beet virus mutation requires Texas touch
2. Research suggests fitness of Florida panthers improved by limited breeding with Texas animals
3. Fire ant-attacking fly spreading rapidly in Texas
4. Wisconsin scientists grow critical nerve cells
5. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
6. UAB scientists discover the origin of a mysterious physical force
7. Fox Chase Cancer Center scientists identify immune-system mutation
8. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
9. U-M scientists find genes that control growth of common skin cancer
10. UCLA scientists transform HIV into cancer-seeking missile
11. RNA project to create language for scientists worldwide
Post Your Comments:
(Date:8/25/2014)... one of the first U.S. outbreaks of the H1N1 ... some 2,000 people. A university math and biology professor ... time to gain insight into how only a few ... the university community., The fall 2009 semester hadn,t even ... university,s Health and Wellness Services clinic11 one day, and ...
(Date:8/25/2014)... of substances known as endocrine disrupting chemicals (EDCs), ... pass from one generation to the next, but ... to EDC may show especially adverse reactions to ... researchers from The University of Texas at Austin ... are affected differently by ancestral exposure to a ...
(Date:8/25/2014)... by manipulating the behavior of ants emits a ... of its natural target host, but not when ... The findings, which suggest that the fungus "knows" ... molecular mechanisms underlying this phenomenon, according to researchers., ... secrete chemicals that affect their environment," noted lead ...
Breaking Biology News(10 mins):WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3Exposure to toxins makes great granddaughters more susceptible to stress 2Zombie ant fungi 'know' brains of their hosts 2Zombie ant fungi 'know' brains of their hosts 3
... In the five months since passage of the ... of research-related awards have been made, supporting important scientific ... increase in basic research funding in American history - ... scientific research and education projects, while $3.5 billion is ...
... 30, 2009) A team of 80 researchers from ... Shifting Sands: Environmental and Cultural Change in Maryland,s Coastal ... barrier islands making up Maryland,s Atlantic coastline. Published ... the history, setting, context and ecology of these waterways, ...
... from the talents of Rembrandt, Van Gogh and other ... of colors on a palette. In a similar manner, ... (NIST) have created an innovative device called the "microfluidic ... concentration across an areain a miniature chamber about the ...
Cached Biology News:'Microfluidic palette' may paint clearer picture of biological processes 2
(Date:8/26/2014)... Mich. , Aug. 26, 2014   ... development of breakthrough oral medicines to treat autoimmune ... immune modulation, today announced the appointment of ... company,s scientific advisory board.  Dr. Singh will lead ... to advance Lycera,s multiple ongoing research programs and ...
(Date:8/26/2014)... , Aug. 26, 2014 Trovagene, ... Next Generation Dx Summit; Moving Assays to the ... Detection and Monitoring of Cell Free Tumor DNA ... analytical component of its Precision Cancer Monitoring (PCM) ... clinical sensitivity for the detection of tumor DNA ...
(Date:8/26/2014)... (PRWEB) August 26, 2014 InstantGMP, Inc., ... processes, implemented a new pricing structure with increased user ... with cGMP and 21 CFR Part 11 requirements. , ... Practices any way we can” said Rick Soltero, President ... of available users allowed customers to have separate accounts ...
(Date:8/26/2014)... 26, 2014 Spartan Bioscience today ... Director of Business Development. Mr. Shah is responsible ... CYP2C19 System in the United States and ... business opportunities and strategic initiatives for the company’s ... Spartan, Mr. Shah was the Global Marketing Product ...
Breaking Biology Technology:Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 2Lycera Appoints Harinder Singh, Ph.D., as Chair of Scientific Advisory Board 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 2Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 4Spartan Bioscience Names Charudutt Shah as Director of Business Development 2
... Market Research, a global provider of pharmaceutical competitive intelligence ... "Thought Leader Insight & Analysis: Alzheimer,s Disease," designed to ... with a stake in the market for diagnostics and ... ). , , MedPredict interviewed ...
... ... On-Site at Komen Western New York Race for the Cure® , ... Ottawa, ON (PRWEB) June 12, 2009 -- DNA Genotek , a ... Roswell Park Cancer Institute (RPCI) to collect DNA saliva samples on-site at the Susan ...
... ... biofuels could be entering the tanks of aircraft, according to the Geneva-based Air Transport Action ... this "new age in flight", the group this week launches a new publication, The Beginner,s ... ...
Cached Biology Technology:New MedPredict Report Reveals Top Alzheimer's Experts' Insights on Diagnostics and Treatments in Development Pipeline 2DNA Genotek Partners with Roswell Park Cancer Institute to Accelerate Breast Cancer Research 2DNA Genotek Partners with Roswell Park Cancer Institute to Accelerate Breast Cancer Research 3Welcome to the Biofuel Age of Flight 2Welcome to the Biofuel Age of Flight 3
... particle based purification systems provide high speed ... sample. They offer increased throughput and reproducible ... KingFisher, KingFisher mL and KingFisher 96, covering ... Each system consists of an instrument, specially ...
... engineered for efficient drying down of synthetic ... cover and a post-trap with ammonia neutralizing ... of samples in ammonium hydroxide., , ... , Comes standard with ...
... Thermo Savant SpeedVac™ Concentrators set the standard ... series SC210A SpeedVac with large chamber uses a ... dry multiple samples in a single run. , ... Rotor Chamber for long lasting chemical compatibility ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
Biology Products: