Navigation Links
Tamoxifen-like drug suggests new ways to selectively block estrogen

The ability of an experimental drug known as GW5638 to change the shape of the estrogen receptor is helping researchers understand why drugs like tamoxifen and raloxifene behave the way they do, simulating the effects of estrogen in some tissues and blocking it in others. The finding indicates that this little-known drug may play an important role in preventing, as well as treating, breast cancer and suggests ways to design new drugs with even more specific effects.

In the May 13, 2005, issue of Molecular Cell, researchers from the University of Chicago, Renz Research, Inc., Duke University and GlaxoSmithKline show how GW5638 fits into a pocket in the estrogen receptor in a way that differs slightly, but importantly, from how tamoxifen fits. The slight difference changes the shape of the receptor in ways that alter its effects on the numerous coregulatory proteins that interact with it.

"We found a small, but significant, change in conformation that goes a long way towards explaining why these drugs have different effects in different tissues," said Geoffrey Greene, Ph.D., professor in the Ben May Institute for Cancer Research at the University of Chicago.

"This type of information should help us design drugs that produce even more specific outcomes. In particular, we could design new small molecules that would be more effective than tamoxifen or raloxifene at preventing breast cancer, heart disease and bone loss without increasing the risk of endometrial cancer."

Tamoxifen and raloxifene are the best-known members of a class of drugs known as specific estrogen receptor modulators or SERMs. These drugs mimic some effects of estrogen and block others. For example, tamoxifen blocks the effects of estrogen in the breast and thus is widely used to treat and prevent breast cancers that depend on estrogen. But it has the opposite effect in the uterus, acting like estrogen to stimulate tissue growth and increasing the risk of uterine cancer.<
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3

Related biology news :

1. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
2. Light therapy may combat fungal infections, new evidence suggests
3. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
4. Community MRSA is re-emergence of 1950s pandemic, study suggests
5. Neandertal femur suggests competition with hyenas and a shift in landscape use
6. Discovery suggests why stem cells run through stop signs
7. Research suggests fitness of Florida panthers improved by limited breeding with Texas animals
8. Preventing a pandemic: Study suggests strategies for containing a flu outbreak
9. Logging doubles threat to the Amazon, rivaling clear-cutting, study suggests
10. Storing carbon to combat global warming may cause other environmental problems, study suggests
11. Same-sex mating by fungi spawned infection outbreak, evidence suggests
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen like drug suggests new ways selectively block estrogen

(Date:11/11/2014)... 2014  Forensicon, Inc., a Chicago ... announce the promotion of Yaniv Schiff from ... In Schiff,s new role as Director, he will lead ... forensics examiners and provide leadership within the company,s digital ... http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined Forensicon in ...
(Date:11/6/2014)... groundbreaking paper from a team of Florida State University ... plants could adapt to and survive environmental swings such ... the latest issue of the journal The Plant ... of DNA and proteins) is organized in a cell ... genes are turned on and others are turned off. ...
(Date:11/5/2014)... has dedicated his career to understanding the Earth,s ... audience. , As deputy director and regional climatologist ... Desert Research Institute, Redmond has more than three ... dissemination of climate data to the general public. ... San Francisco on December 15-19, 2014 the American ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
... tracts (guts) of healthy American children have numerous antibiotic ... by scientists at Washington University School of Medicine in ... they can be shared with harmful microbes, interfering with ... to serious illness and, in some cases, death. ...
... researchers report that the deletion of any single gene in ... leading to a mutation in another gene. Their discovery, which ... DNA is conserved across species, could have significant consequences for ... areas of research, they say. Summarized in a report ...
... of Oceanography at UC San Diego and their colleagues ... that produces a dazzling bioluminescent display in the form ... Found around the world in muddy environments, from shallow ... Chaetopterus marine wormcommonly known as the "parchment ...
Cached Biology News:Gut microbes in healthy kids carry antibiotic resistance genes 2Gut microbes in healthy kids carry antibiotic resistance genes 3Deletion of any single gene provokes mutations elsewhere in the genome 2Deletion of any single gene provokes mutations elsewhere in the genome 3Nature's glowing slime: Scientists peek into hidden sea worm's light 2Nature's glowing slime: Scientists peek into hidden sea worm's light 3
(Date:11/21/2014)... 21, 2014 2014 Deep Research ... is a professional and in-depth research report on ... information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/21/2014)... VANCOUVER , Nov. 20, 2014 /CNW/ - ... pleased to announce that it has closed a ... special warrants for approximately C$3.7 million.  Cormark Securities ... agents in the Brokered Offering for a syndicate ... and PI Financial Corp. (collectively the "Agents"). Concurrently ...
(Date:11/18/2014)... SAN BRUNO, Calif. , Nov. 18, 2014 ... is a platinum sponsor of the 10th Annual World Stem ... and regenerative medicine stakeholders. The 2014 World Stem Cell Summit ... San Antonio, Texas . ... the discovery and development of lifesaving cures and therapies, convening ...
(Date:11/18/2014)... (PRWEB) November 17, 2014 pH measurement ... processes across the pharmaceutical, chemical, and food and beverage ... so important, and how do pH sensors work? METTLER ... assist those in process industries with these questions and ... pH measurement in the process industries. The actual sensor, ...
Breaking Biology Technology:Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2
... End of 2008, NOVATO, Calif., Sept. 25 ... today that its partner Merck,Serono, a division of ... for Kuvan(R) (sapropterin dihydrochloride) as an oral,treatment for ... (BH4) deficiency from the Committee for,Medicinal Products for ...
... 25 Bion Environmental Technologies,Inc. (OTC Bulletin Board: BNET) ... entitled, "Low Oxygen Organic Waste,Bioconversion System" has been granted ... Standard Patent number of 2002227224. The,official filing date is ... be,in force until an expiration date of November 8, ...
... ... in FUNCTIONAL FOOD market-- LAVAL, QC, Sept. ... TSX.V.NTB) reported today,that it entered a worldwide alliance with Marine ... Nutrition for the distribution,of dietary supplements and functional food products ...
Cached Biology Technology:Kuvan Receives Positive Opinion From CHMP for European Approval 2Kuvan Receives Positive Opinion From CHMP for European Approval 3Kuvan Receives Positive Opinion From CHMP for European Approval 4Bion Announces Approval of New Australian Patent for Low Oxygen Organic Waste Bioconversion for Livestock Waste Environmental Treatment 2Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 2Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 3Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 4
Mouse Cell Line Slides...
Request Info...
Human Cell Line Slides...
... Level 2 Detection System combines the ... bonding principle and Signets unique formulation ... specificity and reliablility. Signet reagents will ... manual and automated protocols. ,Signets USA ...
Biology Products: