Navigation Links
Tamoxifen-like drug suggests new ways to selectively block estrogen

The ability of an experimental drug known as GW5638 to change the shape of the estrogen receptor is helping researchers understand why drugs like tamoxifen and raloxifene behave the way they do, simulating the effects of estrogen in some tissues and blocking it in others. The finding indicates that this little-known drug may play an important role in preventing, as well as treating, breast cancer and suggests ways to design new drugs with even more specific effects.

In the May 13, 2005, issue of Molecular Cell, researchers from the University of Chicago, Renz Research, Inc., Duke University and GlaxoSmithKline show how GW5638 fits into a pocket in the estrogen receptor in a way that differs slightly, but importantly, from how tamoxifen fits. The slight difference changes the shape of the receptor in ways that alter its effects on the numerous coregulatory proteins that interact with it.

"We found a small, but significant, change in conformation that goes a long way towards explaining why these drugs have different effects in different tissues," said Geoffrey Greene, Ph.D., professor in the Ben May Institute for Cancer Research at the University of Chicago.

"This type of information should help us design drugs that produce even more specific outcomes. In particular, we could design new small molecules that would be more effective than tamoxifen or raloxifene at preventing breast cancer, heart disease and bone loss without increasing the risk of endometrial cancer."

Tamoxifen and raloxifene are the best-known members of a class of drugs known as specific estrogen receptor modulators or SERMs. These drugs mimic some effects of estrogen and block others. For example, tamoxifen blocks the effects of estrogen in the breast and thus is widely used to treat and prevent breast cancers that depend on estrogen. But it has the opposite effect in the uterus, acting like estrogen to stimulate tissue growth and increasing the risk of uterine cancer.<
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3

Related biology news :

1. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
2. Light therapy may combat fungal infections, new evidence suggests
3. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
4. Community MRSA is re-emergence of 1950s pandemic, study suggests
5. Neandertal femur suggests competition with hyenas and a shift in landscape use
6. Discovery suggests why stem cells run through stop signs
7. Research suggests fitness of Florida panthers improved by limited breeding with Texas animals
8. Preventing a pandemic: Study suggests strategies for containing a flu outbreak
9. Logging doubles threat to the Amazon, rivaling clear-cutting, study suggests
10. Storing carbon to combat global warming may cause other environmental problems, study suggests
11. Same-sex mating by fungi spawned infection outbreak, evidence suggests
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen like drug suggests new ways selectively block estrogen

(Date:6/24/2015)... , June 24, 2015  Synaptics Inc. ... human interface solutions, today announced that Sharp has ... provide secure authentication for its latest flagship smartphone ... more than 200 million shipments of its fingerprint ... reinforces Synaptics, strength, scalability and leadership in the ...
(Date:6/23/2015)...   MedNet Solutions , an innovative SaaS-based ... of clinical research, is pleased to announce that ... company,s intuitive, flexible and affordable cloud-based eClinical technology ... Award by the American Business Awards (SM) ... The American Business Awards are considered the nation,s ...
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
Breaking Biology News(10 mins):Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
... The way the liver renews itself may be simpler than ... the April 13 issue of The Journal of Biological Chemistry, ... regenerating livers that could significantly affect the way physicians make ... hepatitis, or cancer. , "The human liver is one ...
... many to be creepy-crawly, are giving new meaning to ... whip spiders, or amblypygids, mothers caress their young with ... maturity, and all mix in social groups. This is ... aggressive and anti-social, according to a Cornell researcher. ...
... scientists for a dog snapper is actually a new ... of the South Atlantic Ocean. , The international science ... new snapper species that belongs to the Lutjanidae family, ... Kenyon Lindeman of Environmental Defense. The study published in ...
Cached Biology News:Liver regeneration may be simpler than previously thought 2Liver regeneration may be simpler than previously thought 3A rarity among arachnids, whip spiders have a sociable family life 2A rarity among arachnids, whip spiders have a sociable family life 3New species of snapper discovered in Brazil 2
(Date:7/1/2015)... , ... July 01, 2015 , ... Apex Therapeutics announced ... International Convention in Philadelphia, PA. , The presentation took place on Tuesday, ... the plans for the development of APX3330 for the treatment of pancreatic cancer. ...
(Date:6/30/2015)... 2015 R-Japan Co.,Ltd. obtained the license of cell ... Medicine from the Ministry of Health, Labour and Welfare Kinki ... The fact that R- Japan ... from Pharmaceuticals and Medical Devices Agency (PMDA) on May 18, ... provide stem cell manufacturing service to medical institutions. As of ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... a webinar to provide advanced scientific research into new classes of Nanoscale Graphene-based ... energy. Touted as 'the wonder material of the 21st Century' by the ...
(Date:6/30/2015)... Americord Registry, one of the fastest growing cord blood banks ... at Kirkland & Ellis LLP, as the newest member of ...   "We are thrilled about Andrew Horne,s ... , CEO of Americord. "He brings a wealth of knowledge ... growth and vision." Andrew Horne is ...
Breaking Biology Technology:Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4Americord Registry Announces Andrew Horne as Advisory Board Member 2
... week, I gave you my predictions for the coming year ... few of these predictions come true, 2007 is going to ... Lamis , founder of Singularity University , a community ... worried. Second Life becomes a credible next-generation platform ...
... Wis. - To find out whether radio frequency ... blood banking process, the RFID Lab at the ... banks and multiple vendor partners on what is being called ... at RFID's potential role from donation to transfusion, involves the ...
... Inc. , has announced it will price a forthcoming ... at $3.75 per share. , ,Proceeds from the ... 2006, will be used to support research and development ... and intellectual property protection. The Madison-based company, which has ...
Cached Biology Technology:Reader predictions would make 2007 quite a year 2Reader predictions would make 2007 quite a year 3Reader predictions would make 2007 quite a year 4Reader predictions would make 2007 quite a year 5RFID pilot project aims to improve blood banks 2RFID pilot project aims to improve blood banks 3
... is the most thoroughly characterized enzyme available ... its overall utility and efficacy. , Its ... PCR applications. , It is QC ... AmpliTaq DNA Polymerase is a 94 kDa ...
Taq DNA Polymerase (T. aquaticus), 4 x 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying En...
... DNA Polymerase is a versatile and easy-to ... PCR applications. GCpro Taq DNA Polymerase is ... E. coli, containing the DNA polymerase I ... a highly processive 5'-3' DNA polymerase activity. ...
Aspergillus (IgG) Ab EIA Sample Size: 100 l...
Biology Products: