Navigation Links
Tamoxifen for breast cancer prevention does not benefit most women

develop an estrogen receptor-negative tumor, which has a worse prognosis. (Cancers prevented by tamoxifen are mostly estrogen receptor-positive).

In the new study, Melnikow and her colleagues calculate that tamoxifen can be expected to extend life expectancy only when a woman's five-year risk of developing breast cancer reaches 3 percent or more. This is especially true for women who have not had a hysterectomy, and therefore face the risk of endometrial cancer related to tamoxifen use.

Cost-effectiveness was also calculated in the study. For women at the 1.67-percent risk level, taking tamoxifen to stave off breast cancer came to $1.3 million per year of life saved based on the U.S. price of the drug -- a prohibitively expensive cancer-prevention strategy. Melnikow and her co-authors note, however, that the cost-effectiveness equation could be improved if pharmaceutical prices were negotiated at a national level. At Canadian prices, for example, the researchers showed that taking tamoxifen to prevent breast cancer comes to $123,780 per year of life saved for women at the 1.67-percent risk level.

In comparison, annual flu shots cost about $980 per year of life saved for patients ages 65 and older; colonoscopy every 10 years costs about $11,000 per year of life saved for people 50 and older; and annual mammography costs about $58,000 per year of life saved for women ages 40 to 80.

To arrive at their findings, Melnikow and her colleagues used a complex mathematical model based on a hypothetical group of 50-year-old women.

Melnikow specializes in research to better understand women's health-care preferences and how women make health-care decisions. In a study published in the journal Cancer last year, she reported that among women with a five-year breast cancer risk of 1.67 percent or higher, fewer than one in five were inclined to take tamoxifen to prevent the disease. Concern about potential side effects was the primar
'"/>

Source:University of California - Davis


Page: 1 2 3

Related biology news :

1. Tamoxifen-like drug suggests new ways to selectively block estrogen
2. Viral DNA sequence a possible trigger for breast cancer
3. Used in a new way, RNA interference permanently silences key breast cancer gene
4. Biomarkers isolated from saliva successfully predict oral and breast cancer
5. Study reveals dramatic difference between breast cancers in US and Africa
6. Compounds in plastic packaging act as environmental estrogens altering breast genes
7. Alcohol consumption disrupts breastfeeding hormones
8. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
9. Scientists discover genetic pathway responsible for breast cancer cell growth
10. Study hints at role of stem cell genes in testicular, breast cancers
11. Microarray technology for tailoring breast cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen for breast cancer prevention does not benefit most women

(Date:4/22/2014)... Winsor Lowe, interim director of the University of Montana,s ... in the Proceedings of the National Academy of Sciences ... network. , ... the U.S. Geological Survey, the University of Washington, the Cary ... U.S. Forest Service Northern Research Station examined 664 water samples ...
(Date:4/22/2014)... Scientists at the University of Massachusetts Amherst and the ... week report that they have discovered a new genus ... the Negro River in the Amazonia State of Brazil. ... Adlia Nogueira and Jos Antnio Alves-Gomes of INPA, describe ... the journal Proceedings of the Natural Sciences of ...
(Date:4/22/2014)... Mass. Analyzing thousands of breeding bird surveys sent ... and Canada over 35 years, wildlife researchers report that ... either northward or toward higher elevation in response to ... This means that most previous studies of potential climate ... factor or the other have likely underestimated the effects ...
Breaking Biology News(10 mins):New research focuses on streamwater chemistry, landscape variation 2New electric fish genus and species discovered in Brazil's Rio Negro 2Wildlife response to climate change is likely underestimated, experts warn 2
... 2011 Reportlinker.com announces that a new ... catalogue: Global Biometrics Industry ... This report analyzes the worldwide markets ... the following Technologies: AFIS (Automated Fingerprint Identification ...
... CA ---- Researchers at the Salk Institute for Biological Studies ... potentially cure sickle cell disease and many other disorders caused ... The technique uses cells from a patient,s skin to ... developing into various types of mature tissues -- including blood. ...
... the endowments of genes in other animals and plants are like ... a genetic sense introduces an element of variety and surprise that ... in a review of more than 100 studies on the topic ... and colleagues focus on cytosine, one of the four chemical "bases" ...
Cached Biology News:Global Biometrics Industry 2Global Biometrics Industry 3Global Biometrics Industry 4Global Biometrics Industry 5Global Biometrics Industry 6Global Biometrics Industry 7Global Biometrics Industry 8Global Biometrics Industry 9Global Biometrics Industry 10Global Biometrics Industry 11Global Biometrics Industry 12Global Biometrics Industry 13Global Biometrics Industry 14Global Biometrics Industry 15Global Biometrics Industry 16Global Biometrics Industry 17Global Biometrics Industry 18Global Biometrics Industry 19Global Biometrics Industry 20Global Biometrics Industry 21Global Biometrics Industry 22Global Biometrics Industry 23Global Biometrics Industry 24Salk researchers develop safe way to repair sickle cell disease genes 2Salk researchers develop safe way to repair sickle cell disease genes 3Salk researchers develop safe way to repair sickle cell disease genes 4
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
(Date:1/14/2014)... The largest international professional organization of scientists ... derivatives thereof has endorsed an educational program that ... challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural Product ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), ... solutions for patients, physicians, the biopharmaceutical industry, regulators, ... the signing of a three-year Research Collaboration Agreement ... (FDA). This initiative is designed to generate ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... North ... America, DEERFIELD, Ill., ... Cartago, Costa Rica has been,recognized with the 2008 Shingo Prize for Operational ... North America,-- is being honored for its achievements in driving higher quality ...
... announced today it,submitted to the U.S. Food & ... Application (BLA) for motavizumab, an investigational,monoclonal antibody (MAb) ... supported by clinical trial data from more than ... of serious disease,caused by respiratory syncytial virus (RSV) ...
... Unique and Innovative Formulation Available Without a ... Prescription ... today announced the,launch of PSORENT, a clinically proven, steroid-free, ... which has,proven efficacy against psoriasis symptoms, in a novel, ...
Cached Biology Technology:Baxter's Costa Rica Facility Recognized With Shingo Prize for Excellence in Manufacturing 2MedImmune Submits Biologics License Application to FDA for Motavizumab 2MedImmune Submits Biologics License Application to FDA for Motavizumab 3NeoStrata(R) Announces the Launch of PSORENT(TM) Psoriasis Topical Treatment 2
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... FbxL7 The F box, named ... was originally observed, is an approximately ... F-box proteins are components of modular ... (SKP1, cullin, F-box proteins), which function ...
Rabbit polyclonal to SERHL ( Abpromise for all tested applications). entrezGeneID: 94009 SwissProtID: Q9H4I8...
Sheep polyclonal to Staphylococcus DNase ( Abpromise for all tested applications). Antigen: Full length native protein (purified)....
Biology Products: