Navigation Links
Tamoxifen for breast cancer prevention does not benefit most women

Most women at high risk for breast cancer do not increase their life expectancy by taking the drug tamoxifen, according to a new analysis by researchers from UC Davis, UCSF, the University of Pittsburgh and McMaster University in Ontario, Canada. In addition, the researchers showed that tamoxifen is an extraordinarily expensive cancer-prevention strategy, costing as much as $1.3 million per year of life saved. The study will be published in the Sept. 1 issue of the American Cancer Society's journal Cancer, and appear online on Monday.

"We found that for women at the lower end of the high-risk range for developing breast cancer, there is a very small likelihood that taking tamoxifen will reduce mortality," said Joy Melnikow, professor of family and community medicine at UC Davis School of Medicine and Medical Center and lead author of the study. "This would support revising the current recommended risk threshold for physicians to counsel women about tamoxifen."

Tamoxifen was approved by the U.S. Food and Drug Administration in 1998 for breast cancer prevention in women who have at least a 1.67-percent chance of developing the disease over the next five years. Such women are considered at high risk for breast cancer. Groups such as the U.S. Preventive Services Task Force and the Canadian Task Force on Preventive Health Care recommend that physicians counsel women above this threshold about the benefits and risks of tamoxifen as a means of preventing the disease.

Tamoxifen is a selective estrogen receptor-modulating drug used to treat estrogen receptor-positive breast cancers. In addition, it has been shown to reduce the incidence of invasive breast cancer among high-risk women by up to 49 percent.

However, tamoxifen is associated with significant adverse effects, including cataracts requiring surgery, deep vein thromboses, endometrial cancer and stroke. Women taking tamoxifen, if they do develop breast cancer, are also more likely to
'"/>

Source:University of California - Davis


Page: 1 2 3

Related biology news :

1. Tamoxifen-like drug suggests new ways to selectively block estrogen
2. Viral DNA sequence a possible trigger for breast cancer
3. Used in a new way, RNA interference permanently silences key breast cancer gene
4. Biomarkers isolated from saliva successfully predict oral and breast cancer
5. Study reveals dramatic difference between breast cancers in US and Africa
6. Compounds in plastic packaging act as environmental estrogens altering breast genes
7. Alcohol consumption disrupts breastfeeding hormones
8. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
9. Scientists discover genetic pathway responsible for breast cancer cell growth
10. Study hints at role of stem cell genes in testicular, breast cancers
11. Microarray technology for tailoring breast cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen for breast cancer prevention does not benefit most women

(Date:5/20/2015)... 20, 2015 ... announced the addition of the  "5-year ... Recognition Market"  report to their offering.  ... service analyses trends in the iris ... commercial sectors, globally. Despite hardware pricing ...
(Date:5/19/2015)... 2015 Research and ... of the  "Genetic Testing Market Outlook 2018" ... , ,A recent report, Genetic Testing Market ... the current and future genetic testing market. ... working principles and types are covered in ...
(Date:5/11/2015)... 2015  Synaptics Incorporated (NASDAQ: SYNA ), ... announced the appointment of Wajid Ali ... reporting to Rick Bergman , President and ... Officer, Kathleen Bayless , who announced her ... Ali brings extensive financial management expertise to Synaptics, ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Global Genetic Testing Market Outlook 2018 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... developed a more efficient technique for producing biofuels ... that results from conventional biofuel production techniques. The ... commercially viable new source of biofuels. "This ... expensive," says Dr. Ratna Sharma-Shivappa, associate professor of ...
... water, soda pop, or micro brew-beer that you drank in ... natural chemical imprint related to geographic location. When you consume ... hair that could be used to track your travels over ... the first concerted effort to describe the use of beverages ...
... have linked a brain compound called kynurenic acid to ... memory function and treat catastrophic brain diseases, according to ... of Medicine. When researchers decreased the levels of kynurenic ... shown to improve markedly, according to the study, which ...
Cached Biology News:New technique improves efficiency of biofuel production 2Beverages leave 'geographic signatures' that can track people's movements 2UM School of Medicine scientists develop new strategy that may improve cognition 2
(Date:5/21/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: RP) ... focused on the development of autologous cell therapies, ... International Society for Cellular Therapy (ISCT) on RepliCel,s ... in a Phase 1/2 clinical trial.  The presentation, ... 5:30 PM to 7:00 PM local time, will ...
(Date:5/21/2015)... 21, 2015 Tunnell Consulting, ... firm as senior statistician and Principal, a position to ... in the management and analysis of complex and large ... industries. , “We’re delighted to have Julia join the ... analytics,” said Dr. Philippe Cini, Group Vice President and ...
(Date:5/20/2015)... DUBLIN , May 20, 2015 Research and ... addition of the "Top Technologies in HW_Technical Insights" ... division of this report evaluated technology trends in the ... trends that are likely to have an impact in ... depth analysis of the top 10 health and wellness ...
(Date:5/20/2015)... 19, 2015 Research and Markets ( ... "Global Cell Therapy Market Outlook 2020 " report ... in tissue and regenerative medicine is expected to have ... which could help in the growth of deregulated organs. ... they are unable to form new tissue or sometimes ...
Breaking Biology Technology:RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Top Technologies in the Health and Wellness Industry 2015 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3
... medical imaging techniques and lighter and more flexible ... for organic electronics. , Recent experiments ... University of Toronto,s Department of Chemistry may bring ... into the way molecules absorb and move energy. ...
... 2007 07/06 2008 08/07, ... % sales % change, millions ... 36.4 73 14, Other EU Countries 9.7 22 ... 1.4 3 10 2.0 4 ...
... Jan. 15 Caliper Life Sciences, Inc. (Nasdaq: ... its 2008 fourth quarter and full year ended December ... revenue is expected to be approximately $36.5 million for ... for the full year, which is at the upper ...
Cached Biology Technology:U of T chemistry discovery brings organic solar cells a step closer 2Stallergenes: 2008: Sales Up 16% - Excellent Performance - Guidance Exceeded 2Stallergenes: 2008: Sales Up 16% - Excellent Performance - Guidance Exceeded 3Caliper Life Sciences Announces Preliminary 2008 Fourth Quarter and Full Year Revenue Results 2Caliper Life Sciences Announces Preliminary 2008 Fourth Quarter and Full Year Revenue Results 3
Chicken Aortic Smooth Muscle Cells (CAOSMC) (>500,000 cells)...
Canine Chondrocytes (CnC) (500,000 cells)...
B-FABP (FL-132)...
... Lambda Protein Phosphatase ... Mn2+-dependent protein phosphatase with ... threonine and tyrosine residues. ... amino-acid product of the ...
Biology Products: