Navigation Links
Tagging pathogens with synthetic DNA 'barcodes'

A supermarket checkout computer can identify thousands of different items by scanning the tiny barcode printed on the package. New technology developed at Cornell University could make it just as easy to identify genes, pathogens, illegal drugs and other chemicals of interest by tagging them with color-coded probes made out of synthetic tree-shaped DNA.

A research group headed by Dan Luo, Cornell assistant professor of biological engineering, has created "nanobarcodes" that fluoresce under ultraviolet light in a combination of colors that can be read by a computer scanner or observed with a fluorescent light microscope.

Other methods of identifying biological molecules that are available or being developed mostly involve expensive equipment, Luo said. "We wanted something that could be done with inexpensive, readily available equipment," he said. Several years ago researchers created probes consisting of nanoscale bars of metal actually etched with conventional bar codes. Since then, most molecular tagging devices have been referred to as "barcodes," even though there are no bars involved.

The researchers have tested their system using samples containing various combinations of E. coli, anthrax and tularemia bacteria and ebola and SARS viruses, and have found the color codes could clearly distinguish several different pathogens simultaneously.

The research is described in a paper, "DNA fluorescence nanobarcodes for multiplexed pathogen detections," by Luo, Yougen Li, a former Cornell graduate student now at California Institute of Technology, and Yen Thi Hong Cu, a current graduate student, to be published in the July 2005 issue of the journal Nature Biotechnology and available after June 12 in the online version of the journal.

The idea is one of several applications the researchers have found for what they call "dendimer-like DNA," consisting of many short Y-shaped strands of DNA linked together in a treelike structure. The D
'"/>

Source:Cornell University News Service


Page: 1 2 3

Related biology news :

1. A new study examines how shared pathogens affect host populations
2. New lab technique identifies high levels of pathogens in therapy pool
3. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
4. Study: Plants use dual defense system to fight pathogens
5. CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts
6. How Rickettsial pathogens break into cells
7. Ticks, flukes, and genomics: Emerging pathogens revealed
8. Gene thwarts some pathogens, gives access to others, could save crops
9. Researchers map spread of pathogens in the human body
10. Researchers develop technologies to devour food pathogens
11. GreeneChip -- New diagnostic tool that rapidly and accurately identifies multiple pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tagging pathogens with synthetic DNA barcodes

(Date:7/22/2014)... computer science and engineering professor with an expertise in ... Science Foundation grant worth more than $600,000 to develop ... fly., Heng Huang, an associate professor, will lead the ... Arlington Computer Science and Engineering department. Scientists are compiling ... large number of genes involved in fruit fly development ...
(Date:7/22/2014)... 2014) New research from the Monell Center reveals ... can increase airway inflammation in asthmatics for at least ... that expectations can play in health-related outcomes. , "Asthmatics ... expect that an odor is harmful, our bodies react ... lead author Cristina Jan, PhD, a Monell physiologist. "Both ...
(Date:7/22/2014)... not be good for the average steak, but it ... prepare to survive Alaska,s winter cold. , "Alaska wood ... a steak does in your freezer and the frog ... shape than the steak," said Don Larson, University of ... recent paper demonstrating that freeze tolerance in Alaska wood ...
Breaking Biology News(10 mins):UT Arlington big data team wins $600,000 NSF grant to build gene expression database 2In asthma, it's not just what you smell, but what you think you smell 2In asthma, it's not just what you smell, but what you think you smell 3Alaska frogs reach record lows in extreme temperature survival 2Alaska frogs reach record lows in extreme temperature survival 3
... Laval’s Faculty of Medicine have discovered that a ... a pathological reaction in skin cells. Guillaume Morissette, ... about the mode of action of this substance—called ... of Dermatology. , DMAE (2-dimethylaminoethanol) is used in ...
... 15 percent of couples of childbearing age struggle with the ... hope with Cornell researchers' identification of a mutation in a ... the first time that a dominant mutation that leads specifically ... say they can now look for similar mutations in the ...
... made a breakthrough by detecting the electrical equivalent of ... a step closer to both seeing the ‘heartbeat?of a ... , To stay alive, individual biological cells must ... membranes. This flow produces an electrical current that could, ...
Cached Biology News:Anti-wrinkle compound causes pathological reaction in skin cells 2Researchers find gene mutation that causes infertility in male mice 2A new study of living cells could revolutionize the way we test drugs 2
(Date:7/22/2014)... og SHENZHEN , Kina, ... Co., LTD, (BGI Tech), et datterselskab af BGI, ... en ny human whole exome-sekvenseringstjeneste baseret på Complete ... højt anset i branchen for at levere patenterede ... af alle typer varianter, blev købt af BGI ...
(Date:7/22/2014)... , July 22, 2014 Hussey Copper ... MD-Cu 29 antimicrobial copper announces Pullman Regional Hospital,s ... first EPA-registered antimicrobial solid touch surface, at a nominal ... of MRSA, E-coli and other bacteria within 2 hours of ... protecting against bacteria and infectious diseases in its facilities. ...
(Date:7/22/2014)... Quorum Review IRB, the industry leader in central ... called Quick Step™ . The offering went live on ... industry’s need for seamless study start-up with a large volume ... planning 50 or more North American investigator sites, as well ... count of 80 or more. Qualifying studies may also enroll ...
(Date:7/22/2014)... Biofeedback – When a behavioral problem ... medication to best treat it can become a matter ... electroencephalography (EEG) can help predict which medicine will offer ... adverse drug events. , The article “Medication Prediction ... issue of the journal Biofeedback offers evidence that quantitative ...
Breaking Biology Technology:BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3
... , , LAKE MARY, Fla., ... Inc. (NasdaqCM: NGBF) today announced that on August 26, 2009, ... staff indicating that, based on the Company,s stockholders equity as ... the quarter ended June 30, 2009, the Company is no ...
... , BALTIMORE, Md., Aug. 27 Champions Biotechnology, ... development of advanced preclinical platforms and tumor specific data to ... results for the fiscal year ended April 30, 2009. Full ... Company,s Form 10-K available at www.championsbiotechnology.com. , , ...
... , , MURRIETA, Calif., Aug. ... announce the expansion of its US operations. Copan Diagnostics, Inc. ... plastic transfer pipet and additional medical device manufacturing operations to ... addition of blow molding machinery and filling and packing equipment ...
Cached Biology Technology:New Generation Biofuels Receives NASDAQ Notice of Noncompliance with Continued Listing Requirements 2Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 2Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 3Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 4Champions Biotechnology Reports Fiscal 2009 Full-Year Financial Results 5Copan Announces Multimillion Expansion for US Pipet Manufacturing Operations 2
... stain has bright fluorescence when bound to dsDNA ... for detecting dsDNA in gels using laser scanners ... nucleic acid stain has also found uses ... bandshift assays. A 500 µL unit size (S-7563) ...
... cross-linking techniques are defined by the author ... Wong. This valuable hardcover guide includes hundreds ... application references. More than 300 pages detail ... conjugate preparation from selection and design ...
... protein separation by two-dimensional electrophoresis (2D-PAGE), ... package from Bio-Rad and protein identification ... to meet customers requirements regarding experimental ... format of the results permanent contact ...
... reagents for immune complex disruption (ICD) of ... using a combination of low pH and ... transferred to microplate wells which are coated ... to HIV-1 p24. The immobilized monoclonal antibody ...
Biology Products: