Navigation Links
Study reveals dramatic difference between breast cancers in US and Africa

A study comparing, for the first time, breast cancers from Nigeria, Senegal and North America has found that women of African ancestry are more likely to be diagnosed with a more virulent form of the disease than women of European ancestry.

Researchers from the University of Chicago, working with colleagues at the University of Calabar in Nigeria and the University of North Carolina, found that breast cancers in African women produce a different pattern of gene expression. Tumors from African women -- from three locations in Nigeria and one in Senegal -- are more likely to originate from a different group of cells within the breast and often do not present the molecular targets that form the basis of many standard therapies.

"We have known for a long time that breast cancer is not one disease and that it may be somehow different in Africa," said study author Funmi Olopade, M.D., professor of medicine and director of the Center for Clinical Cancer Genetics at the University of Chicago. "But there was no real sense of how much of that was biology and how much was environment. Now we have clear evidence that nature plays an important role. These tumors are biologically quite different in ways that make this a worse disease."

"The discovery means we have to rethink how soon and how often we screen for breast cancer in women at risk for the most aggressive type of breast cancer, as well as how we prevent it and how we treat it," she added. "The guidelines were developed based on our deep knowledge of breast cancer in older women of European ancestry, but our results mean that much of the U.S. and European data simply do not apply to the types of breast cancer we most commonly see in African women."

The researchers studied the pattern of gene expression -- a measure of which genes were turned on and active -- in breast cancer tissue from 378 women in Nigeria and Senegal. They compared the results with a database of breast cancer tissue from
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:7/2/2015)... 2, 2015 Fingerprint Cards has received ... and FPC1155 from the distributor World Peace Industrial Group (WPI), ... in Asia . Deliveries are planned to ... be used by smartphone manufacturers in Asia ... the communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
(Date:6/30/2015)... , June 30, 2015 Genisphere ... as CEO to help further develop Genisphere,s therapeutics capabilities ... partnering experience, having spent much of the last 25 ... Amgen, Baxter Bioscience, and Johnson & Johnson. Tom started ... Technology and Biotech Corporate Finance. He graduated from Dartmouth ...
(Date:6/26/2015)... SPRINGVILLE, Utah , June 26, 2015 ATL ... assemblies and devices with specialties in single use solutions, headquartered ... acquisition of MedConx, Inc. (a California ... , and San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2
... in their dependence on the global food market. The ... common food in its regional hinterland, while Tokyo primarily ... produces less than half of the consumption of the ... mapped the food systems of capital cities, an essential ...
... At a ceremony today, a major international scientific ... journalists for excellence in their coverage of science that ... the world,s largest organization of Earth and space scientists. ... series about Earth and space science for more than ...
... balancing act; too soft and it won,t pump blood, but too ... an optimal amount of strain that a beating heart can generate ... In a study published in the journal Current Biology , ... spot" depends on the stiffness of the collagen framework that the ...
Cached Biology News:Scientists map food security and self-provision of major cities 2Scientists map food security and self-provision of major cities 3AGU honors outstanding journalists 2AGU honors outstanding journalists 3AGU honors outstanding journalists 4Researchers at Penn show optimal framework for heartbeats 2Researchers at Penn show optimal framework for heartbeats 3
(Date:7/3/2015)... ... July 03, 2015 , ... DryLet, ... as animal waste reduction, bioremediation, wastewater treatment, aquaculture and grease, fat and ... that it will be showcasing, ManureMagic™, its industry-leading product for animal waste ...
(Date:7/3/2015)... WIEN , July 3, ... Tiedemiehet voivat hakea verkossa osoitteessa  ... for Open Innovation in Science" ... Ludwig Boltzmann Gesellschaftin (LBG) tekemän, ... tutkimuksen mukaan terveystieteiden kaksi suurinta ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Alexander Group, a ... service industries alike-- typically known for its consummate professionalism-- embarks each year in ... and break from their day jobs. , "Our motto has always been work ...
(Date:7/3/2015)... ... July 03, 2015 , ... The global failure analysis market ... 2015 to 2020. The bioscience market is expected to grow at the highest CAGR ... failure analysis equipment in the research labs and academic institutions for root cause analysis ...
Breaking Biology Technology:DryLet to Highlight Benefits of Patented ManureMagic™ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3The Alexander Group Declares Their Independence with a Bit of Levity 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5
... ITMN ) today announced that John Hodgman, Senior ... at the Jefferies 2nd,Annual Healthcare Conference in New York ... To access a live audio webcast of the presentation, ... investor relations page of InterMune,s,corporate website at http://www.intermune.com ...
... approved by more than 95 percent of votes cast, ... CTIC ; MTA) held a Special Meeting in ... 19, 2008 at its headquarters in,Seattle. At the meeting, ... votes cast at the meeting voting in favor of ...
... University are developing a miniature refrigeration system small ... a cooling technology that would boost performance while ... cooling systems, which use a fan to circulate ... to computer chips, miniature refrigeration would dramatically increase ...
Cached Biology Technology:Shareholders Approve All Matters Proposed by Cell Therapeutics, Inc. at Special Meeting in Lieu of Annual Meeting of Shareholders 2Shareholders Approve All Matters Proposed by Cell Therapeutics, Inc. at Special Meeting in Lieu of Annual Meeting of Shareholders 3Shareholders Approve All Matters Proposed by Cell Therapeutics, Inc. at Special Meeting in Lieu of Annual Meeting of Shareholders 4Tiny refrigerator taking shape to cool future computers 2Tiny refrigerator taking shape to cool future computers 3