Navigation Links
Study hints at role of stem cell genes in testicular, breast cancers

UCSF scientists have discovered that the activity of several embryonic stem cell genes is elevated in testicular and breast cancers, providing some of the first molecular evidence of a link between embryonic stem cells and cancer.

The finding, reported in the November issue of Cancer, suggests that the genes may play a role in the development of tumors or serve as valuable markers of tumor progression, the researchers say. As such, the genes ultimately could lead to new targets for therapy or markers for diagnosis.

A next step, according to the researchers, will be to "dig deeper" to determine the functions of the genes in the cells that make up the tumors.

Another step will be to explore whether the genes are expressed in other cancers, such as prostate cancer.

The genes are known as OCT 4, NANOG, STELLAR and GDF3.

The researchers focused on seminomas ?tumors that account for 50 percent of the cases of testicular cancer, the most frequent cancer in Caucasian males ages 15-40 -- and breast cancers, as represented by a sample of breast cancer cells grown in the culture dish and tissue from a Stage 3 breast tumor.

Previously, the team had discovered that expression of the genes was elevated in two samples of seminomas (Stem Cells, March 2004). In the current study, they expanded their investigation, determining that the expression of the genes was elevated, at varying levels, in nine seminomas.

In the process, they identified the "window" during which seminomas begin to develop. Scientists have known that seminomas arise in sperm-producing germ cells, which are located in the testis and produce sperm in boys following puberty. Germ cells, like all cells of the body, develop from embryonic stem cells, and go through a multi-stage evolution in their structure and genetic activity before attaining their mature state. The study revealed that the genetic misregulation leading to seminomas begins very early in the forma
'"/>

Source:University of California - San Francisco


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study hints role stem cell genes testicular breast cancers

(Date:6/17/2015)... Deutschland und GERMANTOWN, Maryland , June ... ®   Produktlinie mit DNA-Tests verbessert den ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) hat ... STR-Testkits der Produktlinie Investigator ® ... Markt eingeführt. Die neuen Kits zur Erstellung genetischer Fingerabdrücke ...
(Date:6/16/2015)... , June 16, 2015  With the increasing ... security remains a top concern. The recent compromise of ... the need for strong authentication within government agencies. ... a biometric one-time password (OTP) authenticator, has been submitted ... (FIPS) 140-2 Level 3 validation for tamper proofing. ...
(Date:6/15/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, announces that its leading payment security technology, the ... Experience! @ NYC June 18th. Digital Experience! @ ... in technology to over 300 of the top media covering ... Pavilion in New York City from ...
Breaking Biology News(10 mins):QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... finding life on other planets and in extreme environments ... new astrobiology initiative under a five-year grant from NASA,s ... Beyond." Christopher H. House, associate professor of geosciences, ... detect and characterize life, look for biological signatures in ...
... storms will continue to slam the Gulf Coast, and even ... more frequent. , How we handle them will be the ... Storm Prediction and Global Climate Impact in the Gulf Coast ... Storm Prediction, Education and Evacuation from Disaster Center, primary sponsor ...
... Computational Neurobiology Laboratory at the Salk Institute has been ... announced. Election to the IOM is considered one of ... medicine and recognizes individuals who have demonstrated outstanding professional ... "It is a great pleasure to welcome these distinguished ...
Cached Biology News:Penn State receives new NASA astrobiology grant 2Penn State receives new NASA astrobiology grant 3Weather woes emphasize need for SSPEED 2Salk researcher Terry Sejnowski elected to Institute of Medicine 2
(Date:7/3/2015)... ... July 03, 2015 , ... The Alexander Group, a 30-year ... industries alike-- typically known for its consummate professionalism-- embarks each year in a ... break from their day jobs. , "Our motto has always been work hard ...
(Date:7/3/2015)... 2015 Forskare kan ... på  http://www.openinnovationinscience.at till det återkommande utbildningsprogrammet ... hålls i Wien .  ... internationella forskare och vetenskapsmän som genomfördes av ... största utmaningar bristen på incitament för att ...
(Date:7/3/2015)...  Pomerantz LLP announces that a class action lawsuit ... the "Company")(NYSE: PBYI ) and certain of its ... Court, Central District of California , ... class consisting of all persons or entities who purchased ... 2015 inclusive (the "Class Period").  This class action seeks ...
(Date:7/2/2015)... ... ... been used in countless labs for decades. In the past, people had to go ... this was a daunting and tiring process looking at endless data tables and charts. ... the complex catalog structure. , Now thanks to FireflySci, scientists are throwing away those old ...
Breaking Biology Technology:The Alexander Group Declares Their Independence with a Bit of Levity 2Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 2SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 4New Cuvette E-Commerce Website Launched by FireflySci 2
... treatment for the underlying process not just the ... Governor's Business Plan Contest on Tuesday, receiving a ... a University of Wisconsin-Madison spinoff, emerged as an early ... judges. Even before that, co-founder Jeff Johnson, the professor ...
... eleventh-annual and largest-ever Venture Forum was held two weeks ... 130 technology companies to an audience of several hundred ... be of particular interest to Midwest technology entrepreneurs as ... too. , ,The forum is organized by the Larta ...
... State Senator Ted Kanavas remains optimistic that his ... pass the legislature yet this year. , ... Representative Jeff Fitzgerald, R-Horicon, would require companies that ... notify those people when that data is obtained ...
Cached Biology Technology:Alzheimer's drug firm and more winners named in Wisconsin business-plan contest 2Alzheimer's drug firm and more winners named in Wisconsin business-plan contest 3Alzheimer's drug firm and more winners named in Wisconsin business-plan contest 4Midwest fares surprisingly well at Venture Forum in Los Angeles 2Midwest fares surprisingly well at Venture Forum in Los Angeles 3Midwest fares surprisingly well at Venture Forum in Los Angeles 4Kanavas thinks personal ID theft bill will pass this year 2
Human peripheral blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Human peripheral blood basophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
... Isothermal Block is an anodized aluminum, solvent-resistant ... and to provide efficient thermal transfer to ... design of the HT96 Isothermal Block replaces ... product design allowing for compatibility with robotic ...
Biology Products: