Navigation Links
Structures of marine toxins provide insight into their effectiveness as cancer drugs

Vibrantly colored creatures from the depths of the South Pacific Ocean harbor toxins that potentially can act as powerful anti-cancer drugs, according to research findings from University of Wisconsin-Madison biochemists and their Italian colleagues.

The research team has defined the structure of the toxins and provided a basic understanding that can be used to synthesize pharmaceuticals, according to a study published this week in the Proceedings of the National Academy of Sciences (PNAS).

"We've determined how this class of toxins interacts with actin," an important protein responsible for cellular structure and movement, says Ivan Rayment, a professor of biochemistry in the College of Agricultural and Life Sciences who worked with John Allingham, a postdoctoral fellow, on the study. "We're adding to fundamental understanding which will be taken up by others to simplify chemical synthesis of what could potentially be powerful cancer treatments."

The toxins, which are produced naturally by organisms that exist symbiotically on deep-sea sponges, work by disrupting the activity of actin, an abundant protein that gives structure to eukaryotic cells.

"Actin forms long chains, or filaments, that are essential for cellular locomotion, division and growth," explains Allingham. "Because cancer cell masses grow faster than other cells in the body, actin provides an excellent target for drugs that could inhibit such rapid growth."

Adds Allingham: "These marine toxins can knock out the lynchpins in these long chains or cap their ends and kill cancer cells. Moreover, initial work shows that even a low dose of these toxins can bring a significant response."

Prior to the study published in PNAS, it was known that the marine toxins affect several forms of cancer - but not how they worked, says Rayment. The recent findings will enable the toxins to be synthesized in a lab instead of harvested from the depths of the ocean floor, mea
'"/>

Source:University of Wisconsin-Madison


Page: 1 2

Related biology news :

1. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
2. Sequencing of marine bacterium will help study of cell communication
3. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
4. UN environmental agency steps up battle against marine pollution
5. Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils
6. Deep thinking: Scientists sequence a cold-loving marine microbe
7. UNC computer, marine scientists collaborate to predict flow of toxic waters from Katrina
8. UF study first to quantify validity of DNA I.D. tool using marine snails
9. Prenatal exposure to marine toxin causes lasting damage
10. Restaurant seafood prices since 1850s help plot marine harvests through history
11. Compound from marine bacteria shows potential as multiple myeloma therapy
Post Your Comments:
(Date:11/21/2014)... 20, 2014 Strict laws against distracted driving ... the North American and European automotive sector towards gesture ... recognition systems that are intuitive and able to retrieve ... industry. New analysis from Frost & ... in Europe and ...
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that seven officials ... least seven more will participate in the upcoming 2014 PDA ... Washington D.C. , Dec. 2-4. ... the regulatory agencies in the United States ... to help advance the use of metrics in the regulatory ...
(Date:11/10/2014)... U.S. store shelves in early 2010, and people have ... packets can be tossed into a washing machine without ... The convenience, though, has come with risks for young ... Children,s Hospital found that from 2012 through 2013, U.S. ... than 6 years of age swallowing, inhaling, or otherwise ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Study finds laundry detergent pods, serious poisoning risk for children 2
... leading cause of infant deaths worldwide, and particularly a ... can be slow and non-specific, but researchers have now ... identify both the onset of infection and type of ... hotbed of immune system activity, so Stephen Kingsmore and ...
... and Nutrition announced the publication of a study that ... benefits of red wine, is also found in cocoa ... edition of the Journal of Agricultural and Food ... and dark chocolate all have significant levels of resveratrol, ...
... paleontologists may scour remote, exotic places in search of ... to be the world,s oldest whole-body fossil impression of ... strip mall in North Attleboro, Mass. During a ... J. Knecht, a Tufts geology major, and Jake Benner, ...
Cached Biology News:Resveratrol, red wine compound linked to health, also found in dark chocolate and cocoa 2Researchers uncover world's oldest fossil impression of a flying insect 2Researchers uncover world's oldest fossil impression of a flying insect 3
(Date:11/26/2014)... (PRWEB) November 25, 2014 Whitehouse ... officially joined the Morris County (New Jersey) Chamber ... is a leading business organization in the North ... to further engage some key clients in the ... in the geographic area. Membership enables Whitehouse Laboratories ...
(Date:11/26/2014)... Global biostimulants market is expected to reach ... CAGR of 12.5%. In order to cater to ... ecological impacts, farmers are looking to adopt natural ... more effectively & efficiently. Biostimulants are consequently seen ... on investments. , Leading companies in the biostimulants ...
(Date:11/26/2014)... 25 novembre 2014 Theravalues Corporation est fier ... marché européen au salon Hi Europe 2014 (du ... ). Curcumine la plus biodisponible actuellement ... (non-cristalline) à des ingrédients approuvés par les règlements ... jaune présent dans la racine de curcuma ( ...
(Date:11/24/2014)... UAE, November 24, 2014 Five ... Bin Rashid Al Maktoum Awards for Medical Sciences", in ... Dubai, United Arab Emirates , on 15 December ... , The Carter Center which won the ... actively involved in numerous programs that aim to improve ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Five US Winners Among Recipients of Hamdan Medical Awards 2
... ... The Northern Irish packaging machinery manufacturer, Sepha Ltd. is breaking into one ... leak testing and de-blistering machines for the first time ... July. Ahead of its presence at Interphex, Sepha has already ...
... SYDNEY, June 29 /PRNewswire-Asia/ -- Pharmaxis (ASX: PXS; ... million from its Share Purchase Plan which,closed on 24 June ... purchase up to $5,000 worth of shares each at the ... A total of 1,584 shareholders participated ...
... BD (Becton, Dickinson and Company) (NYSE: ... of its third fiscal quarter 2009 earnings conference call on Thursday, ... a press release detailing the quarter,s earnings earlier that morning. , ... slides, will be accessible through BD,s website at www.bd.com/investors ...
Cached Biology Technology:Asia Debut for Money-Saving Pharma-Packaging Machines from Ireland 2Asia Debut for Money-Saving Pharma-Packaging Machines from Ireland 3Pharmaxis Closes Share Purchase Plan 2