Navigation Links
Structures of marine toxins provide insight into their effectiveness as cancer drugs

Vibrantly colored creatures from the depths of the South Pacific Ocean harbor toxins that potentially can act as powerful anti-cancer drugs, according to research findings from University of Wisconsin-Madison biochemists and their Italian colleagues.

The research team has defined the structure of the toxins and provided a basic understanding that can be used to synthesize pharmaceuticals, according to a study published this week in the Proceedings of the National Academy of Sciences (PNAS).

"We've determined how this class of toxins interacts with actin," an important protein responsible for cellular structure and movement, says Ivan Rayment, a professor of biochemistry in the College of Agricultural and Life Sciences who worked with John Allingham, a postdoctoral fellow, on the study. "We're adding to fundamental understanding which will be taken up by others to simplify chemical synthesis of what could potentially be powerful cancer treatments."

The toxins, which are produced naturally by organisms that exist symbiotically on deep-sea sponges, work by disrupting the activity of actin, an abundant protein that gives structure to eukaryotic cells.

"Actin forms long chains, or filaments, that are essential for cellular locomotion, division and growth," explains Allingham. "Because cancer cell masses grow faster than other cells in the body, actin provides an excellent target for drugs that could inhibit such rapid growth."

Adds Allingham: "These marine toxins can knock out the lynchpins in these long chains or cap their ends and kill cancer cells. Moreover, initial work shows that even a low dose of these toxins can bring a significant response."

Prior to the study published in PNAS, it was known that the marine toxins affect several forms of cancer - but not how they worked, says Rayment. The recent findings will enable the toxins to be synthesized in a lab instead of harvested from the depths of the ocean floor, mea
'"/>

Source:University of Wisconsin-Madison


Page: 1 2

Related biology news :

1. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
2. Sequencing of marine bacterium will help study of cell communication
3. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
4. UN environmental agency steps up battle against marine pollution
5. Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils
6. Deep thinking: Scientists sequence a cold-loving marine microbe
7. UNC computer, marine scientists collaborate to predict flow of toxic waters from Katrina
8. UF study first to quantify validity of DNA I.D. tool using marine snails
9. Prenatal exposure to marine toxin causes lasting damage
10. Restaurant seafood prices since 1850s help plot marine harvests through history
11. Compound from marine bacteria shows potential as multiple myeloma therapy
Post Your Comments:
(Date:4/24/2014)... in Munich have identified the structural features that ... viral and endogenous RNAs in living cells. , ... cellular metabolism and hijack cellular resources for the ... on viral RNA molecules that are delivered directly ... newly synthesized in the host cell, and provide ...
(Date:4/24/2014)... study of animal intelligence to-date finds that animals with bigger ... week in the journal Proceedings of the National Academy ... history of research aimed at understanding the animal mind. Specifically, ... and use tools, read social cues, or even understand basic ... of animal intelligence have focused on only one or a ...
(Date:4/24/2014)... could be improved with new insights into the make-up ... studying the Amazon Basin have revealed unprecedented detail of ... region by comparing satellite maps with hundreds of field ... assess more accurately the amount of carbon each tree ... offset schemes, in which trees are given a cash ...
Breaking Biology News(10 mins):Viral infections: Identifying the tell-tale patterns 2Viral infections: Identifying the tell-tale patterns 3Animals with bigger brains, broader diets have better self control 2Animals with bigger brains, broader diets have better self control 3Amazon rainforest survey could improve carbon offset schemes 2
... Ill. The overuse of nitrogen fertilizers in agriculture ... An international team of scientists aims to lessen ... similar plants boost their nitrogen production, even in areas ... Center of Plant Genomics and Biotechnology at the Technical ...
... fires and urban and agricultural areas in California is ... to a recent study published in the journal ... ecologist from the U.S. Forest Service,s Pacific Southwest Research ... at Devils Postpile National Monument in the eastern Sierra ...
... A potential new way to fight obesity-related illness has ... at the Case Western Reserve University School of Medicine. ... Cleveland Clinic Foundation and Cornell University, discovered the essential ... brought on by obesity. "The implications of our findings ...
Cached Biology News:Strengthening legumes to tackle fertilizer pollution 2Air pollution diminishing air quality at Devils Postpile National Monument 2Vitamin E identified as potential weapon against obesity 2Vitamin E identified as potential weapon against obesity 3
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of ... regulatory, business, and media events in the United States ... former associate Virginia Cox , JD, is returning to the ... Virginia Cox re-joins 3D after more than two years of ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest ... research medicinal plants and therapeutic derivatives thereof has ... professionals, and researchers about the challenges of adulterated ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society for ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 In recent ... motives and methods in product development and promotion has ... industry. This mistrust, fueled by concerns about the insidious ... by reports of spectacular fines to the world’s biggest ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... a bill Friday designed to promote capital investment and ... loans. The legislation, SB 261 , was only ... Ted Kanavas, R-Brookfield, to hit the Assembly floor this ... the Wisconsin Capital Companies Program, (WISCAP) is a revised ...
... MILWAUKEE - The benefits of switching to voice over ... meeting at the Italian Community Center in Milwaukee. Nearly ... their experiences with VoIP. , ,Clear reasons for switching ... and Pat Scheckel, VoIP practice director for Berbee Information ...
... MADISON - Inacom Education , announced today that it ... of Microsoft Technology Trainers United Training. United Training ... Technology training centers from around the country who have met ... membership. , , In order to qualify for ...
Cached Biology Technology:Wisconsin Assembly passes capital investment bill, revised CAPCO program not presented 2Wisconsin Assembly passes capital investment bill, revised CAPCO program not presented 3VoIP: Are we there yet? 2
Mouse monoclonal [TU-20] to beta III Tubulin (FITC) ( Abpromise for all tested applications). entrezGeneID: 10381 SwissProtID: Q13509...
Phospho-FKHR (Thr24)/FKHRL1 (Thr32) Antibody...
Mouse anti-Insulin-Like-3 Class: Antibody Product Group: Adipokine and Obesity related...
... BRF2 Immunogen Synthetic peptide: QAARQAATSVPNPP, corresponding ... BRF2. Reactivity / Specificity Cross-reacts with ... Background Information BRF2 is one of the ... factor complex required for transcription of genes with ...
Biology Products: