Navigation Links
Speak up: Louder neurons form more connections

As the brain develops, neurons reach out helter-skelter forming new connections, only a small number of which take hold. How the brain chooses which connections to keep and which to prune back appears to be governed by which branches have the most electrical activity—a finding that could help to explain how early experiences guide brain development.

The work, published in the April 21 issue of Nature, takes advantage of tiny, see-through zebrafish. Stephen Smith, PhD, professor of molecular and cellular physiology at the Stanford University School of Medicine, and his graduate student Jackie Hua immersed 3-day-old fish in a breathable, Jell-O-like substance that kept the fish alive but immobile. The researchers could then focus video cameras on the fish’s developing brain to watch how the branches of individual neurons grew and shrank over time.

It turns out that determining which of the branches will grow follows an age-old axiom: The squeaky neuron gets the grease. “Louder neurons drown out their quieter neighbors,?Smith said.

Working out this seemingly simple rule took some technical finesse. Hua created zebrafish with a few brain cells that made a protein that prevented them from firing their normal electrical signals. These cells were also engineered to produce a protein that glowed green under the appropriate light.

Hua looked for green neurons in her immobilized fish to see how their branches fared compared with neighboring neurons that fired normally. The green neurons didn’t compete well.

Although the poorly-firing green neurons still formed extensive branching structures, which the researchers call the neuron’s arbor, most of those branches eventually receded while neighboring neurons formed a large number of stable connections. When the fish were five days old, the green neurons had a smaller, less complex arbor than those of neighboring neurons.

“We know that the arbor should occupy a certain amount of space
'"/>

Source:Stanford University


Page: 1 2

Related biology news :

1. First real-time view of developing neurons reveals surprises, say Stanford researchers
2. One gene links newborn neurons with those that die in diseases such as Alzheimers
3. Researchers make surprise discovery that some neurons can transmit three signals at once
4. Eating, body weight regulated by specific neurons
5. New neurons take baby steps in the adult brain
6. Algal protein in worm neurons allows remote control of behavior by light
7. Picking apart how neurons learn
8. Researchers get neurons and silicon talking
9. Mechanism for memory revealed in neurons of electric fish
10. Attention shoppers: Researchers find neurons that encode the value of different goods
11. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Speak Louder neurons form more connections

(Date:4/16/2014)... Sometimes known as Kennedy,s disease, spinal and bulbar muscular atrophy ... progressive muscle weakness and atrophy. Researchers have long considered it ... the cells in the spinal cord and brainstem that control ... the April 16, 2014 online issue of Neuron , ...
(Date:4/16/2014)... store memories improves during childhood, associated with structural changes ... parietal cortices. New research from UC Davis is exploring ... Eventually, that could give insights into disorders that typically ... affect memory, such as schizophrenia and depression. , Located ...
(Date:4/15/2014)... Ohio (April 16, 2014)A new study from the Women,s ... D levels and menopause symptoms. The study was published ... The North American Menopause Society., The authors analyzed the ... a number of menopause symptoms, including hot flashes, night ...
Breaking Biology News(10 mins):Mutant protein in muscle linked to neuromuscular disorder 2How kids' brain structures grow as memory develops 2Low Vitamin D may not be a culprit in menopause symptoms 2
... April 9, 2012 Scientists from Duke University Medical ... switches can define clinically relevant molecular subtypes of ovarian ... prognostic and diagnostic testing. These bimodal genes can define ... to different therapeutic regimens. The researchers, results are ...
... to predictions of which plant species will escape extinction from ... world, posing a great challenge to plants in all ecosystems, ... biology and senior author of the research. Scientists have debated ... are most vulnerable. Sack and two members ...
... (Boston) Researchers at Boston University School of Medicine ... population of pure lung and thyroid progenitor cells in ... and thyroid tissue formation. The research, which will be ... Cell Stem Cell , identifies factors necessary for ...
Cached Biology News:Researchers identify genes that may help in ovarian cancer diagnosis and prognosis 2Which plants will survive droughts, climate change? 2Which plants will survive droughts, climate change? 3Which plants will survive droughts, climate change? 4Which plants will survive droughts, climate change? 5BU researchers derive purified lung and thyroid progenitors from embryonic stem cells 2
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
(Date:1/15/2014)... Freeslate, Inc ., the leading provider of ... one of India’s top five pharmaceutical companies, has received ... for high throughput solid form screening. , Lupin, ... range of quality, affordable generic and branded formulations and ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have ... at 2pm EST (11am PST), “Natural Language Processing: Converting ... how technology can turn raw, heterogeneous data into actionable ... The online webinar will last approximately one hour. , ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 EquitiesIQ, a ... Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical company ... the wound care market. , Free report download: ... with a seasoned management team and Board, which launched ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Conn., April 29 Core Informatics announces,that it ... LIMS product,to BioRelix Pharmaceuticals of New Haven, CT. ... the need to establish a,strong data management infrastructure ... the LIMS marketplace, BioRelix choose the Core LIMS., ...
... Aflac and the American,Association for Cancer Research (AACR) ... Development Award for Childhood Cancer Research,endowed by Aflac ... cancer. The award,which includes a two-year grant of ... in San Diego, Calif., to Dr. Charles G. ...
... Points from the First Quarter of 2007 to ... 66.3% - Company Prepares to Launch ... ... leading developer and manufacturer of a broad array of,light-based aesthetic treatment systems, today announced record revenues,and ...
Cached Biology Technology:Core Informatics Delivers Enterprise Core LIMS Installation to BioRelix Pharmaceuticals 2Aflac and the American Association for Cancer Research Unite to Issue Inaugural Aflac Career Development Award for Childhood Cancer Research 2Aflac and the American Association for Cancer Research Unite to Issue Inaugural Aflac Career Development Award for Childhood Cancer Research 3Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 2Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 3Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 4Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 5Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 6Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 7Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 8Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 9Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 10Cynosure Reports 41% Revenue Increase: 10th Consecutive Quarter of Revenue Growth 11
Mouse monoclonal antibody raised against a partial recombinant ACTN4. NCBI Entrez Gene ID = ACTN4...
Mouse monoclonal antibody raised against a partial recombinant CAPG. NCBI Entrez Gene ID = CAPG...
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... The E. coli protein sample is ... give a consistent pattern when used ... and sample buffer. This sample can ... validate your 2-D system and protocol ...
Biology Products: