Navigation Links
Speak up: Louder neurons form more connections

As the brain develops, neurons reach out helter-skelter forming new connections, only a small number of which take hold. How the brain chooses which connections to keep and which to prune back appears to be governed by which branches have the most electrical activity—a finding that could help to explain how early experiences guide brain development.

The work, published in the April 21 issue of Nature, takes advantage of tiny, see-through zebrafish. Stephen Smith, PhD, professor of molecular and cellular physiology at the Stanford University School of Medicine, and his graduate student Jackie Hua immersed 3-day-old fish in a breathable, Jell-O-like substance that kept the fish alive but immobile. The researchers could then focus video cameras on the fish’s developing brain to watch how the branches of individual neurons grew and shrank over time.

It turns out that determining which of the branches will grow follows an age-old axiom: The squeaky neuron gets the grease. “Louder neurons drown out their quieter neighbors,?Smith said.

Working out this seemingly simple rule took some technical finesse. Hua created zebrafish with a few brain cells that made a protein that prevented them from firing their normal electrical signals. These cells were also engineered to produce a protein that glowed green under the appropriate light.

Hua looked for green neurons in her immobilized fish to see how their branches fared compared with neighboring neurons that fired normally. The green neurons didn’t compete well.

Although the poorly-firing green neurons still formed extensive branching structures, which the researchers call the neuron’s arbor, most of those branches eventually receded while neighboring neurons formed a large number of stable connections. When the fish were five days old, the green neurons had a smaller, less complex arbor than those of neighboring neurons.

“We know that the arbor should occupy a certain amount of space , and in these fish it doesn’t take up that much space,?Hua said.

Hua gave those losing neurons a fighting chance through another molecular twist. She managed to silence some neurons near the green, quietly-firing cells. When she did that, the green cells were able to compete successfully and formed longer, more complex arbors.

Although this work specifically examined the brains of fish, Smith said the same rules likely apply to all neurons, including those in the human brain. “Probably these same things are happening all the time,?he said.

Neurons that fire regularly while learning to recognize a new person’s face, for example, will form larger arbors with more connections that help retain that memory for the future. Likewise, neurons stimulated by engaging toys or experiences will probably create larger arbors than similar neurons in less exciting conditions.

“We are looking at a dynamic part of development,?Smith said. “These are the connections that let us think and fight and love.?/p>
'"/>

Source:Stanford University


Related biology news :

1. First real-time view of developing neurons reveals surprises, say Stanford researchers
2. One gene links newborn neurons with those that die in diseases such as Alzheimers
3. Researchers make surprise discovery that some neurons can transmit three signals at once
4. Eating, body weight regulated by specific neurons
5. New neurons take baby steps in the adult brain
6. Algal protein in worm neurons allows remote control of behavior by light
7. Picking apart how neurons learn
8. Researchers get neurons and silicon talking
9. Mechanism for memory revealed in neurons of electric fish
10. Attention shoppers: Researchers find neurons that encode the value of different goods
11. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/29/2016)... 29, 2016 LegacyXChange, Inc. (OTC: ... and SelectaDNA/CSI Protect are pleased to announce our successful ... a variety of writing instruments, ensuring athletes signatures against ... collectibles from athletes on LegacyXChange will be assured of ... DNA. Bill Bollander , CEO states, ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... ... 26, 2016 , ... After several promising treatments in Panama ... City of Knowledge in Panama, a 6 year-old Duchenne’s muscular dystrophy patient received ... year following FDA approval of a second application for a single patient, investigational ...
(Date:5/25/2016)... Portland, Oregon (PRWEB) , ... May 25, 2016 ... ... Base Set features a variety of fracture-specific plating options designed to address fractures ... provide industry-leading fracture fixation solutions. , The Acumed Ankle Plating System 3 is ...
(Date:5/25/2016)... ... May 25, 2016 , ... Lady had been battling arthritis since ... ligament in her left knee. Lady’s owner Hannah sought the help of Dr Jeff ... surgeon, to repair her cruciate ligament and help with the pain of Lady’s arthritis. ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... identity. The new Media Cybernetics corporate branding reflects a results-driven revitalization for a ... image analysis. The re-branding components include a crisp, refreshed logo and a new ...
Breaking Biology Technology: