Navigation Links
Speak up: Louder neurons form more connections

As the brain develops, neurons reach out helter-skelter forming new connections, only a small number of which take hold. How the brain chooses which connections to keep and which to prune back appears to be governed by which branches have the most electrical activity—a finding that could help to explain how early experiences guide brain development.

The work, published in the April 21 issue of Nature, takes advantage of tiny, see-through zebrafish. Stephen Smith, PhD, professor of molecular and cellular physiology at the Stanford University School of Medicine, and his graduate student Jackie Hua immersed 3-day-old fish in a breathable, Jell-O-like substance that kept the fish alive but immobile. The researchers could then focus video cameras on the fish’s developing brain to watch how the branches of individual neurons grew and shrank over time.

It turns out that determining which of the branches will grow follows an age-old axiom: The squeaky neuron gets the grease. “Louder neurons drown out their quieter neighbors,?Smith said.

Working out this seemingly simple rule took some technical finesse. Hua created zebrafish with a few brain cells that made a protein that prevented them from firing their normal electrical signals. These cells were also engineered to produce a protein that glowed green under the appropriate light.

Hua looked for green neurons in her immobilized fish to see how their branches fared compared with neighboring neurons that fired normally. The green neurons didn’t compete well.

Although the poorly-firing green neurons still formed extensive branching structures, which the researchers call the neuron’s arbor, most of those branches eventually receded while neighboring neurons formed a large number of stable connections. When the fish were five days old, the green neurons had a smaller, less complex arbor than those of neighboring neurons.

“We know that the arbor should occupy a certain amount of space
'"/>

Source:Stanford University


Page: 1 2

Related biology news :

1. First real-time view of developing neurons reveals surprises, say Stanford researchers
2. One gene links newborn neurons with those that die in diseases such as Alzheimers
3. Researchers make surprise discovery that some neurons can transmit three signals at once
4. Eating, body weight regulated by specific neurons
5. New neurons take baby steps in the adult brain
6. Algal protein in worm neurons allows remote control of behavior by light
7. Picking apart how neurons learn
8. Researchers get neurons and silicon talking
9. Mechanism for memory revealed in neurons of electric fish
10. Attention shoppers: Researchers find neurons that encode the value of different goods
11. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Speak Louder neurons form more connections

(Date:3/12/2015)... Va. , March 12, 2015 IriTech, ... and a member of the Texas Instruments Design Network, ... Naidu has demonstrated its IriShield USB MK2120U device ... scanning facility for pension distribution. The ... assembled to be marketed in India ...
(Date:3/11/2015)... --  The Sync Project™ today announced the ... harness music to improve health. The platform maps ... of physiology, enabling the study of the therapeutic ... It is designed for medical and health research, ... and accelerate the discovery of the clinical applications ...
(Date:3/5/2015)... PAULO , March 5, 2015 In ... 41 percent of companies already using these solutions and 42 ... 2015. Of the latter, approximately 25 percent of the companies ... While the majority of companies in the region ... anticipated that the hybrid model will command significant attention in ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4
... volume says Dutch researcher Bas Tomassen. He investigated the uptake ... and human cells. , Cell volume is the outcome ... the cell plasma membrane. A cell can regulate its volume ... Exactly how this process works is still not known. Bas ...
... Scientists at the Forsyth Institute have found that three ... of oral cancer--a discovery the researchers hope will lead ... , The findings also open the question of whether ... , The current discovery, reported in the July 7 ...
... interaction of negatively charged lipids and DNA molecules have ... delivery systems that will assist doctors and clinicians in ... As reported in the Aug. 9 issue of the ... now performed a careful, comprehensive study to see how ...
Cached Biology News:Water management in cells 2Forsyth scientists find three bacteria associated with oral cancer 2Forsyth scientists find three bacteria associated with oral cancer 3'Cookbook recipes' would cure disease with nontoxic DNA delivery systems 2
(Date:3/30/2015)... CARDIFF, UK, and BELLINGHAM, Washington, USA (PRWEB) March 29, ... energy projects in Europe and the United States and ... programme highlights planned for SPIE Optics + Optoelectronics ... will feature over 700 technical presentations in 17 conferences ... international society for optics and photonics , the event ...
(Date:3/29/2015)... Texas , March 29, 2015  Caris ... studies in which Caris Molecular Intelligence®, the company,s ... similarities and differences between several rare and difficult ... strategies that have the potential to improve patient ... Session B at the Society of Gynecologic Oncology ...
(Date:3/27/2015)... The consumption of compound fertilizers (NPK) fertilizers declined ... prices in 2008. However, the situation has stabilised afterwards, ... momentum now. , To date, the world annual production ... tonnes. No considerable growth was registered in the market ... 2012-2013, registering 11% growth as against the period of ...
(Date:3/27/2015)... 27, 2015 Working in collaboration with ... London , Richmond Pharmacology is the first ... 3 study for an investigational RNAi therapeutic being developed for ... the nerves and heart. Read press release ... Based at St Georges University of London ...
Breaking Biology Technology:Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 2Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 2Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 4World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3
... today publicly announced the world,s first free website allowing patients ... a standard web browser , ... ... (HeartIT®) today publicly announced the world,s first free website allowing ...
... HUNTINGTON BEACH, California and AMSTERDAM, February 4 ... diagnostics, today announced that,its signature breast cancer ... of,care for all eligible early stage breast ... Leeuwenhoek Hospital (NKI-AVL). The NKI-AVL,believes MammaPrint provides ...
... materials and equipment produces high-performing cold weather biodieselSAN ... Industries, the world,s largest producer of small-to-medium scale ... clean-tech energy platforms, announces the release of "Greenline ... combines a proprietary blend of materials with a ...
Cached Biology Technology:World's First Website for Patients to Share Diagnostic-Quality Medical Images 2Agendia's Breast Cancer Test MammaPrint(R) Standard of Care at Netherlands Cancer Institute - AVL 2New Greenline Tea FASTRACK Solves Cold-Flow Issues 2
... light balance makes your life easier. It offers a ... management for one balance. *Instruments supported: ... MX, UMX, AG, XS, XP, PR, SR, PG-S, PG, ... management: User guidance ...
... enable rapid analytical to medium scale affinity ... appropriate vectors. Sufficient reagents are provided for ... protein under native or denaturing conditions. Crude ... specifically retains STag fusion proteins. After unbound ...
Request Info...
... Ingredients (g/L):,Tryptone, 10 ,Yeast extract, 5 ... 0.3 ,Ferric ammonium citrate, 0.5 ,IPTG, ... water soluble, autoclavable chromogenic substrate for ... by -galactosidase generates a black insoluble ...
Biology Products: