Navigation Links
Source of molecular triggers in cutaneous T cell lymphoma identified

In a study published in the journal Blood, Yale scientists identify the molecular triggers that stimulate Cutaneous T Cell Lymphoma (CTCL) cells to clonally expand into large populations of malignant lymphocytes.

CTCL is the most common adult malignancy of T lymphocytes, the white blood cells of the immune system. Finding CTCL triggering factors has been a major goal of Richard L. Edelson, M.D., Director of the Yale Cancer Center, and professor and chair of dermatology at Yale, since he and his colleagues at the National Cancer Institute first identified CTCL as a separate category of lymphoma thirty years ago.

The Yale research group reported that, like all T cells, the cancerous CTCL cells require antigenic stimuli delivered by specialized dendritic cells of the epidermis, referred to as Langerhans cells (LC), in order to replicate.

To determine the nature of the activating antigen, Carole Berger, a research scientist in dermatology set up a physiologic laboratory system mimicking the tight relationship in vivo between CTCL cells and LC. The research team considered three broad categories of antigen as the source of the signal: the protein products of tumor viruses, of mutated genes, and of normal but usually inactive genes.

The study reports that CTCL develops from a small subset of lymphocytes that are pre-programmed to respond to self-antigens exposed during normal cell death. As cells undergo the process of apoptosis, cryptic -- or masked -- antigens, are uncovered. Those newly available antigens are presented by LC directly to CTCL receptors, stimulating the malignant cells rapidly divide.

"This finding has broad implications for the understanding, diagnosis, and treatment of CTCL, as well as potentially contributing to the investigation of other types of lymphomas," said Edelson. "It may now be possible to identify specific antigens and target the malignant cells with selective poisons delivered through the vehicle of L C."

The study also showed that CTCL cells, after stimulation by LC, become functioning regulatory T (Treg) cells that suppress the immune responses of normal T cells to microbial agents. This may explain the susceptibility of patients with extensive CTCL to opportunistic infections.

"Through understanding T cell and dendritic cell interactions, we may gain the ability to manage a spectrum of maladies ranging from cancer to disorders of immune regulation," said Edelson. "Inhibiting Treg-cell generation may be useful for cancer immunotherapy and promoting Treg development may be useful to induce tolerance in autoimmune disease and transplantation,"


'"/>

Source:Yale University


Related biology news :

1. Finding Cures For Tropical Diseases: Is Open Source An Answer?
2. Placenta Is A Rich Source Of Blood Stem Cells
3. Open Source Biotechnology alliance for international agriculture
4. Source of crucial immune cell in the skin discovered
5. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
6. Plants, animals share molecular growth mechanisms
7. NYU researchers simulate molecular biological clock
8. Scientists reveal molecular secrets of the malaria parasite
9. Scientists identify molecular events that drive cell senescence
10. Researchers discover molecular mechanism that desensitizes us to cold
11. Findings have implications for tracking disease, drugs at the molecular level
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... ... green this month, the response was swift and efficient thanks to the continuing ... RRWQG is made up of more than 50 stakeholders, including officials from area ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... today announced the election of Paul Hermes, Entrepreneur in Residence at Medtronic, Inc., ... Biorez has developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament (ACL) reconstruction ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... today that it has appointed Vishwas Paralkar to the role of chief scientific ... targeting technology. He will report to Cybrexa’s president and CEO, Per Hellsund. , ...
(Date:9/20/2017)... TX (PRWEB) , ... September ... ... LLC (IPS), a leading global provider of engineering, architecture, project controls, construction ... of prefabricated cleanrooms, today announced the unveiling of the iCON™ brand which ...
Breaking Biology Technology: