Navigation Links
Sleeping sickness parasite shows how cells divide their insides

Researchers at Yale have brought to light a mechanism that regulates the way an internal organelle, the Golgi apparatus, duplicates as cells prepare to divide, according to a report in Science Express.

Graham Warren, professor of cell biology, and his colleagues at Yale study Trypanosoma brucei, the parasite that causes Sleeping Sickness. Like many parasites, it is exceptionally streamlined and has only one of each internal organelle, making it ideal for studying processes of more complex organisms that have many copies in each cell.

When thinking about how cells divide, doubling and separating DNA in chromosomes is often the focus. Equally important is the way a cell prepares its internal organelles for distribution. Warren studies the Golgi complex, a membrane compartment in the cytoplasm that delivers newly-made proteins to different membranes in the cell.

"Basal bodies in particular and centrosomes in general have been implicated in the biogenesis of a number of membrane-bound organelles," said Warren. "It prompted us to study further their role in Golgi duplication."

Warren's group has identified a new cellular structure, distinct from the basal body, involved in the duplication of the Golgi apparatus and defined by a highly-conserved protein, Centrin2. This structure has two lobes -- one at the old Golgi, the other where the new Golgi forms. Once a new Golgi has grown, the Centrin structure itself duplicates so that two complete structures, and associated Golgi, are ready to be allocated to daughter cells.

Significant recent advances in the molecular genetics of trypanosomes by Elisabetta Ullu and Christian Tschudi's group at Yale, allowed direct man ipulation of protein levels using the innate RNA interference (RNAi) system.The relationship between the growing Golgi, the Centrin proteins and other cellular organelles was shown in experiments using RNAi, and visualizing the process was possible with fluorescent protein tags. How this process relates to higher organisms is the focus of present research.


'"/>

Source:Yale University


Related biology news :

1. Sleeping Sickness Epidemic Spreading in Uganda
2. Sleeping beauty plays a significant role in identifying cancer genes
3. Newly discovered protein an important tool for sleeping sickness research
4. Compound might defeat African sleeping sickness, clinical trial beginning this month
5. A large step forward in the fight against African sleeping sickness
6. Resistance and genetic sensitivity to sleeping sickness
7. New study suggests promising drug combinations for sleeping sickness
8. Scientists reveal molecular secrets of the malaria parasite
9. Protein offers way to stop microscopic parasites in their tracks
10. A human parasite with a streamlined mitochondrion
11. Invasive parasite destroying fish species
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative ... ... Maldives Immigration ... Algeen (small picture on the right) have received the IAIR award for ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 8.8% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
Breaking Biology News(10 mins):
(Date:6/27/2017)... ... ... The recent vote by the American Medication Association to align with the World ... hopefully sheds new light on the way health insurers, governments and the public view ... of Texas Fertility Center . , “This designation is something we have ...
(Date:6/27/2017)... ... June 27, 2017 , ... Biodex Medical Systems, Inc. announces ... in one device. This assistive aid lifts patients safely from a seated to a ... lift mechanics. The Mobility Assist is the latest in a line of Biodex products ...
(Date:6/27/2017)... ... June 27, 2017 , ... Indiana-based Xylogenics announced ... production and fermentation process. The efficiencies created by the newest strain design ... notably the ethanol industry wherein individual production plants are planning to invest upwards ...
(Date:6/26/2017)... ... June 26, 2017 , ... NDA Partners Chairman ... Director of Product Development R&D at Allergan and CMC expert with more than ... and established biopharma companies, has joined the firm as an Expert Consultant. ...
Breaking Biology Technology: