Navigation Links
Sleeping beauty plays a significant role in identifying cancer genes

Researchers at the University of Minnesota Cancer Center and the National Cancer Institute (NCI), part of the National Institutes of Health, have discovered a new method that could accelerate the way cancer-causing genes are found and could lead to a more accurate identification of the genes, according to two studies in the July 14, 2005, issue of Nature.

The gene identification method was developed in genetically modified mice and utilized a piece of jumping DNA, called Sleeping Beauty. Jumping genes, or transposons, insert themselves into or between genes and can activate or inactivate a gene's normal function. Related transposons are natural to the genetic makeup of humans, animals and fish, but, through millions of years of evolution, most transposons became inactive dead-ends. In 1997, in another study, University of Minnesota researchers took defunct, non-functioning jumping genes from fish and made the genes jump again. This research had reactivated the jumping genes from millions of years of evolutionary sleep; hence the name Sleeping Beauty.

In the two current research studies, specially designed Sleeping Beauty transposons were introduced into mouse DNA and made to jump around in the nucleus of mouse cells. Eventually the transposons jumped into cancer-causing genes and caused a tumor to form. By isolating and studying the genes from tumors that contained Sleeping Beauty, researchers were able to efficiently find genes linked to cancer by seeing whether Sleeping Beauty turned them on or off -- in effect, uncovering the fingerprint of each tumor's cancer genes.

David Largaespada, Ph.D., associate professor and leader of the Genetic Mechanisms of Cancer Program, led the University of Minnesota Cancer Center research team. Their work focused on cancer gene discovery in solid tumors using transposon-based techniques.

"Current cancer gene identification methods, such as microarrays, give correlations typically of thousands of gene
'"/>

Source:NIH/National Cancer Institute


Page: 1 2 3

Related biology news :

1. Sleeping Sickness Epidemic Spreading in Uganda
2. Sleeping sickness parasite shows how cells divide their insides
3. White blood cell waste disposal system plays critical regulatory role
4. Micro-molecule plays big role in birth defects
5. Neural stem cell gene plays crucial role in eye development
6. Got inexpensive contrast agent? Milk plays new role in imaging
7. Zinc plays important role in brain circuitry
8. Fish species plays surprise role in aiding coral reef recovery
9. Anticipation plays a powerful role in human memory, brain study finds
10. Motor protein plays key role in connecting neurons
11. Confirmed -- deforestation plays critical climate change role
Post Your Comments:
(Date:10/15/2014)... bacterial pneumonia in female mice to an enzyme activated ... naturally more resistant to respiratory infections than males. Now, ... resistance to bacterial pneumonia in female mice is linked ... also show that this enzyme is ultimately activated by ... The team, lead by Professor Lester Kobzik at the ...
(Date:10/14/2014)... shows SIRT6—a protein known to inhibit the growth ... skin cancers by turning on an enzyme that increases ... Previously considered protective, SIRT6 is part of a family ... stability and prevent some of the genetic flaws associated ... lead to cancer. This study, in the journal,s October ...
(Date:10/14/2014)... October 14, 2014 – High doses of fish oil supplements, ... a common type of irregular heartbeat in which the heart ... results of the AFFORD trial led by the Montreal Heart ... College of Cardiology on October 7th. , For the ... therapy were randomly assigned to 4 grams of fish oil ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... 2013   EyeLock Inc. , a market leader of ... Michael Fiorito as Vice President of ... expansion of the EyeLock,s proprietary iris authentication solutions ... role, Fiorito will be responsible for managing all ...
... August 15, 2013 German researchers have identified four ... and contribute to the accurate prediction of patient outcomes. ... The Journal of Molecular Diagnostics . Current ... size, and number of foci, have limited usefulness for ...
... People who often recall their dreams respond more strongly ... the great mysteries of human cognition. It is still not ... brain produce them. A major difficulty for studying dreams is ... Perrine Ruby and colleagues from the Lyon Neuroscience Research ...
Cached Biology News:EyeLock Appoints Michael Fiorito Vice President of Enterprise Accounts 2MicroRNAs have diagnostic and prognostic potential in urinary bladder cancer 2Frontiers news briefs: Aug. 13 2Frontiers news briefs: Aug. 13 3
(Date:10/20/2014)... Convey Computer , the leader in ... State University won first place in the 2014 ... the team’s solution achieved the highest overall performance in ... place finisher. , Experts from all segments of the ... challenge, using a variety of design tools, hardware and ...
(Date:10/20/2014)... , Oct. 20, 2014 PureTech ... company tackling big healthcare problems, announced today the ... round, with participation from Invesco Perpetual, a $120 ... used to drive PureTech,s existing pipeline forward and ... "PureTech has the scientific creativity to really go ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 ... Industry Meeting (ABIM). ABIM will take ... More information about ABIM 2014 is now ... , Delegates representing companies and organizations from ... and obtain information on the latest products ...
(Date:10/19/2014)... 2014 The report "Chocolate, Cocoa Beans, ... Prices, Geography Trend and Forecast (2011 - 2016)," ... geography and studies the major market drivers, restraints, and ... and Asia. , The global chocolate market is expected ... in 2016 at an estimated CAGR of 2.7% from ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4
... Meeting October 23, IRVINE, California, October 16 ... orthobiologics company, today announced the,interim tabulation results of ... and adjourned to October 23, 2007. Prior ... percent,of the shares entitled to vote, voted for ...
... Fresh data on mass spectrometry are presented in ... derived from ortho-, meta-, and para-hydroxyphenyl carbaldehydes, ketones, ... and his colleagues in the Center for Mass ... According to a study, Collision-induced dissociation (CID) mass ...
... 15 The Liver Meeting is the premier,meeting in ... on new drugs, novel treatments, and the results from ... have some form of liver disease,and the diseases strike ... There are now numerous treatments,for both hepatitis B and ...
Cached Biology Technology:IsoTis Reports Interim Results of Vote for Integra Merger 2IsoTis Reports Interim Results of Vote for Integra Merger 3IsoTis Reports Interim Results of Vote for Integra Merger 4Stevens researchers provide new information about mass spectrometry 2
... Features Convenient platform for tube handling ... 96 x 0.2ml V-bottom tubes - ... Plates - Thermo-Fast® 96 Non-Skirted Plate ... - 48 x 0.5ml Thermo-Tubes Multiple workstations ...
... 96 well Magnetic-Ring Stand is designed for ... U-bottom microplates. The stand has a plastic ... microtiter plate footprint. The use of 96 ... and easy magnetic separation. With this magnetic ...
... - 5 units/µL ,• High specific activity ... Leaves an 'A' overhang ,• Processes ... very high activity in primer extension and ... quality of the enzyme, each lot has ...
Taq DNA Polymerase (T. aquaticus), 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzyme...
Biology Products: