Navigation Links
Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm

In higher order animals, genetic information is passed from parents to offspring via sperm or eggs, also known as gametes. In some single-celled organisms, such as yeast, the genes can be passed to the next generation in spores. In both reproductive strategies, major physical changes occur in the genetic material after it has been duplicated and then halved on the way to the production of mature gametes or spores. Near the end of the process, the material ?called chromatin, the substructure of chromosomes ?becomes dramatically compacted, reduced in volume to as little as five percent of its original volume.

Researchers at The Wistar Institute, studying the mechanisms that control how the genetic material is managed during gamete production, have now identified a single molecule whose presence is required for genome compaction. Their experiments showed that the molecule "marks" the chromatin just prior to compaction and that its presence is mandatory for successful compaction. Additionally, after first noting the molecule's activity during the production of yeast spores, the scientists saw the same activity during the creation of sperm in fruit flies and mice, suggesting that the mechanisms governing genome compaction are evolutionarily ancient, highly conserved in species whose lineages diverged long ago. A report on the new study appears in the September 15 issue of Genes & Development. A "Perspectives" review in the same issue expands on the significance of the findings.

"This molecular mark is required at a critical time leading up to genome compaction in spores and sperm," says Shelley L. Berger, Ph.D., the Hilary Koprowski Professor at The Wistar Institute and senior author on the study. "Also, there seems to be a similarity in the way the mark is used in organisms as different from each other as yeast and mammals, suggesting that compaction has been important throughout evolution."

Berger speculates that compaction might answer a nu
'"/>

Source:The Wistar Institute


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Single stem cells from bone heal a broken heart
3. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
4. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
5. Single gene is genetic switch for fly sexual behavior
6. Single microRNA causes cancer in transgenic mouse
7. Single cell amoeba increases MRSA numbers 1000- fold
8. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
9. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
10. Source of molecular triggers in cutaneous T cell lymphoma identified
11. Plants, animals share molecular growth mechanisms
Post Your Comments:
(Date:6/23/2015)... 23, 2015   Valencell, a leader ... of a recent study that illustrates its PerformTek ... during activity. In a study conducted at Valencell,s ... with the Apple Watch against a chest strap ... during activity. The study demonstrated that Valencell,s biometric ...
(Date:6/17/2015)... , June 17, 2015 QIAGEN ... launched new Investigator ® STR assay kits for analysis ... United States . The new genetic fingerprint kits provide ... (short tandem repeats or STRs) for DNA matching. They incorporate ... of DNA in each sample, a novel QIAGEN technology that ...
(Date:6/16/2015)... 16, 2015 Fingerprint Cards has received ... in the company,s portfolio from one of its module partners ... mainly take place during the third quarter 2015. The sensors ... . Jörgen Lantto, CEO of FPC, comments: ...   growing interest from smartphone OEMs in integrating touch fingerprint ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2
... have an ambiguous, obscure or hidden meaning. In biology, ... hidden inside their genes. Two University of Michigan ... clams, long believed to be members of the same ... the rocky shores of southern Australia for millions of ...
... the poor maxillary sinuses. Those bulbous pouches on either side ... and causing sinus infections than anything else. They were thought ... little known present value. Yet researchers led by the ... fortuitous, integral role in the shape and function of the ...
... Beers, the popular Texas craft brew, will launch a nationwide ... at the Translational Genomics Research Institute (TGen). The Waylon ... Wednesday, March 13, at the Hotel San Jos in downtown ... The noon-8 p.m. event, themed after the legendary Armadillo ...
Cached Biology News:Cryptic clams: U-M biologists find species hiding in plain view 2Cryptic clams: U-M biologists find species hiding in plain view 3The nose's unheralded neighbor 2The nose's unheralded neighbor 3Shiner Beers launches nationwide support of TGen diabetes studies 2
(Date:7/1/2015)... 2015 Isagenix International, a leading global health ... three Silver, and three Bronze Stevie® Awards at the ... Chicago this month.The American Business ... program in the U.S. "Winning is ... developing leaders, cultivating talent, creating a unified team, and ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... Apex Therapeutics ... BIO International Convention in Philadelphia, PA. , The presentation took place on ... outlined the plans for the development of APX3330 for the treatment of pancreatic cancer. ...
(Date:6/30/2015)... 2015 R-Japan Co.,Ltd. obtained the license of cell ... Medicine from the Ministry of Health, Labour and Welfare Kinki ... The fact that R- Japan ... from Pharmaceuticals and Medical Devices Agency (PMDA) on May 18, ... provide stem cell manufacturing service to medical institutions. As of ...
(Date:6/30/2015)... CA (PRWEB) , ... June 30, 2015 , ... ... (AFM) is hosting a webinar to provide advanced scientific research into new classes ... bio science and energy. Touted as 'the wonder material of the 21st ...
Breaking Biology Technology:Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4
... VEGAS, Nov. 17, 2011 Cord Blood America, Inc . ... umbilical cord blood stem cell preservation company focused on ... and internationally, today is pleased to announce that it has been ... announced by the DTCC in December 2010 has been removed. ...
... Nov. 16, 2011 Thomas Industrial Network ... Media Program to help industrial businesses build brand ... attract leads. Increasingly, engineers, purchasing agents, ... seeking information and advice for their businesses on ...
... SAN DIEGO, Nov. 15, 2011 Ambit Biosciences ... Martino as President, Chief Executive Officer and member ... Ambit a nearly 30-year track record in leading ... through late-stage clinical development, fundraising, commercial and business ...
Cached Biology Technology:Cord Blood America Announces DTCC Removes "Chill" Imposed in December 2010 2Introducing a New, Easy Way for Industrial Businesses to Join the Online Conversation 2Ambit Biosciences Names Michael A. Martino President and Chief Executive Officer 2Ambit Biosciences Names Michael A. Martino President and Chief Executive Officer 3Ambit Biosciences Names Michael A. Martino President and Chief Executive Officer 4
...
For use with SSP products or any application requiring agarose gel separation • Multiple formats available to meet various throughput needs • Includes replacement parts for each un...
...
Request Info...
Biology Products: