Navigation Links
Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm

In higher order animals, genetic information is passed from parents to offspring via sperm or eggs, also known as gametes. In some single-celled organisms, such as yeast, the genes can be passed to the next generation in spores. In both reproductive strategies, major physical changes occur in the genetic material after it has been duplicated and then halved on the way to the production of mature gametes or spores. Near the end of the process, the material ?called chromatin, the substructure of chromosomes ?becomes dramatically compacted, reduced in volume to as little as five percent of its original volume.

Researchers at The Wistar Institute, studying the mechanisms that control how the genetic material is managed during gamete production, have now identified a single molecule whose presence is required for genome compaction. Their experiments showed that the molecule "marks" the chromatin just prior to compaction and that its presence is mandatory for successful compaction. Additionally, after first noting the molecule's activity during the production of yeast spores, the scientists saw the same activity during the creation of sperm in fruit flies and mice, suggesting that the mechanisms governing genome compaction are evolutionarily ancient, highly conserved in species whose lineages diverged long ago. A report on the new study appears in the September 15 issue of Genes & Development. A "Perspectives" review in the same issue expands on the significance of the findings.

"This molecular mark is required at a critical time leading up to genome compaction in spores and sperm," says Shelley L. Berger, Ph.D., the Hilary Koprowski Professor at The Wistar Institute and senior author on the study. "Also, there seems to be a similarity in the way the mark is used in organisms as different from each other as yeast and mammals, suggesting that compaction has been important throughout evolution."

Berger speculates that compaction might answer a nu
'"/>

Source:The Wistar Institute


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Single stem cells from bone heal a broken heart
3. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
4. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
5. Single gene is genetic switch for fly sexual behavior
6. Single microRNA causes cancer in transgenic mouse
7. Single cell amoeba increases MRSA numbers 1000- fold
8. Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese
9. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
10. Source of molecular triggers in cutaneous T cell lymphoma identified
11. Plants, animals share molecular growth mechanisms
Post Your Comments:
(Date:5/20/2015)... OXFORD, Conn. , May 20, 2015 ... "Company") announces that its wholly owned subsidiary, 3D-ID LLC, ... contractor under Team Battelle for the biometrics technology portion ... Unrestricted Suite Contract from the Department of the Army. ... facial recognition products developed for government, law enforcement and ...
(Date:5/14/2015)... DUBLIN , May 14, 2015 Research and ... addition of the "Fingerprint Sensors Market in Smart ... This report believes that 2014 was a watershed ... to Apple,s introduction of ,Apple Pay,. Apple gave fingerprint ... its mobile payment service. Fingerprint sensors are a must-have ...
(Date:5/10/2015)... 2015 Fingerprint Cards (FPC) has received ... from the distributor World Peace Industrial Group (WPI), part of ... Asia . Deliveries are planned to take place ... smartphone manufacturers in China . The order ... guidance of + 1 000 MSEK for 2015.   ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... University Medical Center have illuminated a window into ... that regulate expression of numerous genes, may contribute ... schizophrenia and possibly other brain disorders. In ... Karayiorgou, M.D., professor of psychiatry, and Joseph A. ...
... eat like horses. Hatching inside over-ripe fruit where they were laid, ... an offer they cant refuse. To survive, they must leave the ... food as if it were poison. Only then can the larvae ... their own eggs. Now, a team of researchers from the ...
... Solution allows straightforward migration to EAC ePassport technology, ... ePassport,technology, Entrust, Inc. (Nasdaq: ENTU ) will ... government to help authenticate sensitive,biometric information stored on ... ePassports -- which will be available to nearly ...
Cached Biology News:Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs 2Fruit fly avoidance mechanism could lead to new ways to control pain in humans 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 3
(Date:5/27/2015)... Caris Life Sciences®, a leading biotechnology company ... announced it has appointed the Levine Cancer Institute, part ... in the Caris Centers of Excellence for Precision Medicine ... one of the largest cancer care providers throughout the ... annually. Derek Raghavan , M.D., Ph.D., President of ...
(Date:5/26/2015)... Kalifornien und HILDEN, Deutschland, May 26, 2015 ... Insight ®   ermöglicht ... die Erstellung dazugehöriger Berichte; Vorstellung auf den ... QIAGEN N.V. (NASDAQ: QGEN ; ... Markteinführung von QIAGEN Clinical Insight ® ...
(Date:5/26/2015)... CHENGDU, China , May 26, 2015 ... pharmaceutical company that specializes in the patented biopharmaceutical, modernized ... ingredients (API), announced that the Company,s Annual Meeting of ... was scheduled to be held at the Company,s office ... via conference call, at 9:00 AM (local time in ...
(Date:5/26/2015)... Pharmaco-Kinesis Corporation (PKC) announced today that its ... on the Beach in Santa Monica, CA ... Company,s innovative Metronomic Biofeedback Pump (MBP), a fully smart ... time to a target site of the human body ... in real-time.  ...
Breaking Biology Technology:Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 2Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 3Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 4QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 2QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 3QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 4QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 5QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 6TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 2TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 3Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 2Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 3Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 4Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 5
... (Amex: ETC ) ("ETC" or the "Company") ... additional BARA-MED(R) XD,Monoplace Hyperbaric Chambers to Comprehensive Healthcare ... company who focuses,solely on initiating and operating Wound ... total of five (5) BARA-MED(R) XD chambers,from ETC ...
... Oct. 9 /Xinhua-PRNewswire-FirstCall/ -- China Yingxia,International, Inc. ... "the,Company"), a leading provider in the health ... manufacture and distribution of nutritional,food products, dietary ... People,s,Republic of China ("PRC"), today announced that ...
... from around the world join forces in the Global Fight ... on the parasite Plasmodium falciparum, which is responsible for the ... of the same genus which, despite producing a milder form ... Plasmodium vivax , to which is attributed almost 300 ...
Cached Biology Technology:Environmental Tectonics Corporation Announces a Multiple Sale of Hyperbaric Monoplace Chambers to Comprehensive Healthcare Solutions 2Environmental Tectonics Corporation Announces a Multiple Sale of Hyperbaric Monoplace Chambers to Comprehensive Healthcare Solutions 3Environmental Tectonics Corporation Announces a Multiple Sale of Hyperbaric Monoplace Chambers to Comprehensive Healthcare Solutions 4China Yingxia International, Inc. Announces $2 Million Share Repurchase Program 2China Yingxia International, Inc. Announces $2 Million Share Repurchase Program 3The Plasmodium vivax genome provides new routes and challenges in the global fight against malaria 2The Plasmodium vivax genome provides new routes and challenges in the global fight against malaria 3
Based on Silica membrane matrix beads. The kit is designed for the purification of DNA (20 bp - 100 bp) from TAE/TBE agarose gels. Run time is approximately 45 minutes....
Includes USB cable, custom driver and one roll of thermal paper...
Mycoplasma and virus tested...
... Gel Loading Buffer is ... and tracking of DNA ... native polyacrylamide gels. This ... density sucrose which allows ...
Biology Products: