Navigation Links
Similar Stem Cells In Insect And Human Gut

Looking through his handmade microscope in 1702, it was Anton van Leeuwenhoek who first described the workings of a nano machine. He observed the rapid contraction of a stalk tethering the cell body of a tiny protozoan, Vorticella convallaria, to the surface of a leaf. Little did van Leeuwenhoek imagine that more than 300 years later, the biological spring that drives Vorticella would set records for speed and power in the nano world of cellular engines.

It might also power future generations of nano devices and materials, according to biological engineer Danielle Cook France and colleagues at MIT, the Whitehead Institute, the Marine Biological Laboratory, and the University of Illinois, Chicago. France presented her findings Sunday at the 45th Annual Meeting of the American Society for Cell Biology in San Francisco.

The spring in the unicellular Vorticella is a contractile fiber bundle, called the spasmoneme, which runs the length of the stalk. At rest, the stalk is elongated like a stretched telephone cord. When it contracts, the spasmoneme winds back in a flash, forming a tight coil. To find out how fast and how hard Vorticella recoils, France and colleagues used modern microscopes and tools to measure the force and speed of the spring. This is one powerful engine, France reports. The spasmoneme's contraction is measured in nano-newtons of force and centimeters/second of speed in a biological world where the ruler markings are usually in tiny pico-newtons and micrometers/second. Gram for gram, the power of the spasmoneme engine outperforms human muscles and car engines.

It also runs on a different fuel. Molecular motors that power muscle contraction, for example, use ATP molecules for energy. The spasmoneme runs on calcium, but its drive mechanism was poorly understood until France and colleagues got under the nano hood. Like van Leeuwenhoek, the researchers studied Vorticella under the microscope but they also had specialized biochemical methods to slow and inhibit the contraction, to freeze-frame it, and to discern details of the calcium fuel system.

Earlier research had identified a cellular protein, spasmin, as the possible calcium-responsive component of the stalk. "The Vorticella spasmins are now known to belong to the centrin family of calcium-binding proteins," says France. "Centrins are ubiquitous to eukaryotic cells and some family members are found in filamentous structures in organisms other than Vorticella, ranging from green algae to humans."

In sorting out centrin's role in the Vorticella spring, France and colleagues found that an antibody to Vorticella centrin abolished contractility. Along with other evidence, this interference suggests that the spasmoneme uses a powerful centrin-based mechanism that is unlike any complex actin or microtubule-based cellular engine, says France. "This leads us closer to understanding two things: how cells use centrin-based engines to generate enormous forces and how we can possibly reconstruct centrin-based materials and devices for our own use at the micrometer and nanometer scales."


'"/>

Source:


Related biology news :

1. Jump-starting T Cells In Skin Cancer
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
4. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
5. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
6. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
7. Placenta Is A Rich Source Of Blood Stem Cells
8. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
9. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
10. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
11. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... MA (PRWEB) , ... June 23, 2016 , ... ... Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute ... platform of microbial tests introduced last year,” stated Bob Salter, Vice President of ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... , ... June 23, 2016 , ... In a new ... in Denmark detail how a patient who developed lymphedema after being treated for breast ... results could change the paradigm for dealing with this debilitating, frequent side effect of ...
(Date:6/23/2016)... -- Andrew D Zelenetz , ... Published recently in Oncology & ... Andrew D Zelenetz , discusses the fact ... placing an increasing burden on healthcare systems worldwide, ... the patents on many biologics expiring, interest in ...
Breaking Biology Technology: