Navigation Links
Sea coral's trick helps scientists tag proteins

The glow emitted by a variety of sea coral helped Russian scientists harness the protein that generates the light to create a tiny fluorescent tag that responds to visible light. The two-color tag should help researchers follow individual proteins as they dart around inside living cells.

Under a microscope, the two-color tag--called Dendra because it is derived from the sea coral Dendronephthya--first shows up as a green glow, highlighting the otherwise invisible protein to which it is attached. The green turns to red when the tags are zapped with an intense pulse of visible blue light.

The dramatic color change "makes it possible to precisely label an object, such as a cell, organelle, or protein, with a flash of light and then to follow the object's movement over time," said Konstantin Lukyanov, whose group conducted the Dendra research in the lab of his brother, Sergey Lukyanov, a Howard Hughes Medical Institute (HHMI) international research scholar at the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences in Moscow. "This tool opens new possibilities for studying protein and organelle dynamics in living cells, cell migration during embryogenesis, inflammation, and other pathological and normal processes," he said.

Unlike other green-to-red fluorescent markers, Dendra can be activated by visible blue light, which is less harmful to living cells and does not require special laser equipment, Konstantin Lukyanov explained. In fact, the light source of the laser-scanning confocal microscopes that researchers commonly use to peer into living cells can activate the tag, which should make the new tool useful to many scientists, said Sergey Lukyanov, whose lab reports on the Dendra tag in the April 2006 issue of Nature Biotechnology, published in advance online on March 19, 2006.

Importantly, Dendra is small enough to highlight proteins without interfering with their folding or function. And the resea
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Old drug, new tricks: Prospects for slashing the impact of malaria
2. Dangerous tricksters: Some bacterie use immune cells to reproduce
3. Researchers use trickery to create immune response against melanoma
4. New finding points way to foiling anthraxs tricks
5. A wolf in sheeps clothing: Plague bacteria reveal one of their virulence tricks
6. An AIDS-related virus tricks cells to become tumors, new Penn study finds
7. Scientists perform tricky operation
8. Yale biologists trick viruses into extinction
9. Toxoplasmosis infection trick revealed by scientists
10. Jumping gene helps explain immune systems abilities
11. Protein helps regulate the genes of embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sea coral trick helps scientists tag proteins

(Date:9/15/2014)... simple, mechanical solution to avoid chromosome sorting errors, ... Express. , This natural safeguard ... to infertility, miscarriage, or congenital conditions. , ... but what exactly goes wrong is often not ... Center for Cell Biology at the University of ...
(Date:9/15/2014)... When this week,s print issue of the journal ... up from New Mexico, Montana and even the Netherlands, ... more and more the norm in these connected times. ... it will produce innovations in biology, medicine, biotechnology and ... this scientist talked with that one, that one knew ...
(Date:9/15/2014)... assistant professor in the Department of Science and Technology ... Human Sciences at Virginia Tech, has won a 2014 ... study the prospects and problems of creating a global ... Japan,s Fukushima I Nuclear Power Plant in March 2011 ... viewed nuclear emergencies, Schmid said. Three of the plant,s ...
Breaking Biology News(10 mins):Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3Collaboration drives achievement in protein structure research 2'Nuclear disasters don't respect national boundaries' 2
... GAINESVILLE, Fla. --- Imagine a Web site like Facebook, ... post quizzes like "What ,80s song are you?" scientists ... few mouse clicks separating them from information needed for ... $12.2 million National Center for Research Resources grant awarded ...
... , REDWOOD CITY, Calif., Oct. 20 DigitalPersona, ... solutions, today announced that WAND Corporation, a leading ... has integrated DigitalPersona technology into their NextGen POS ... now use fingerprint biometrics to boost cashier accountability ...
... a new approach to prepare ancient DNA with a ... an MU animal scientist, along with a team of ... tree" for cows and other ruminants, going back as ... allow scientists to understand the evolution of cattle, ruminants ...
Cached Biology News:UF receives $12.2 million to establish national network of scientists 2UF receives $12.2 million to establish national network of scientists 3WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 3MU research team establishes family tree for cattle, other ruminants 2
(Date:9/15/2014)... by Northeastern University has developed a novel method ... variety of nanocarbon structures in carbon nanotube arrays. ... will allow the researchers to tailor the physical ... ranging from electronic devices to CNT-reinforced composite materials ... , Their findings were published in the journal ...
(Date:9/15/2014)... The chemistry, taste, and health effects of tea ... published by the nonprofit American Botanical Council (ABC). Recent research ... its effects on the phytochemical compounds in tea ( Camellia ... Dr. Ahmed in the Yunnan province ... for the future of medicinal botanicals. Dr. Ahmed,s report ...
(Date:9/15/2014)... , Sept. 15, 2014  The second annual ... October 12-18. A joint initiative of the Plasma ... companies , IPAW is designed to: , ... Recognize the contributions of plasma donors in saving and ... protein therapies and rare diseases Member ...
(Date:9/13/2014)... September 13, 2014 Boehringer Laboratories Inc., ... is proud to announce the successful broadcast of a ... surgeons Leonardo Claros, MD, FACS, FAMBS, and Maher El ... Gastrectomy Calibration System. , This sleeve gastrectomy surgery ... of more than four hundred surgeons from around the ...
Breaking Biology Technology:Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 2International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2
... ... V™ series to its portfolio. , ... San Francisco, Calif. (PRWEB) October 2, 2009 -- Perceptum Group, ... for biotech and specialty pharma companies. The new series includes Situational Leadership V™, Situational ...
... , ... Venture Network (SCVN) announces the recipients of the 2009 Orange County Emerging Growth Awards, ... yearly revenues, have experienced significant growth over the last 12 months and that have ... ...
... the consequences can be fatal, not only for the creature ... fuselage, causing stresses in the material which can later turn ... detect such damage at an early stage and simplify maintenance ... need any cables or batteries. They draw their energy from ...
Cached Biology Technology:Perceptum Group Announces New Situational Leadership V Series 2Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 2Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 3Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 4Energy-autonomous sensors for aircraft 2
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... Orbital Shakers combine high durability and ... power. The patented triple-counterbalanced heavy-duty ... to run with heavy out-of-balance loads. ... reduces contamination. The heavy stainless ...
... T4 Polynucleotide Kinase (PNK) catalyzes ... ATP to the 5'-hydroxyl of single- ... 3'-monophosphates. The enzyme also removes the ... and deoxyribonucleoside 3', 5'-diphosphates to form ...
The Cellject Elecroporator is suitable for all cell types including embryo, mammalian, plant, yeast and bacterial. Its has highly user-freindly programing and can be used remotely, for example in a l...
Biology Products: