Navigation Links
Sea coral's trick helps scientists tag proteins

The glow emitted by a variety of sea coral helped Russian scientists harness the protein that generates the light to create a tiny fluorescent tag that responds to visible light. The two-color tag should help researchers follow individual proteins as they dart around inside living cells.

Under a microscope, the two-color tag--called Dendra because it is derived from the sea coral Dendronephthya--first shows up as a green glow, highlighting the otherwise invisible protein to which it is attached. The green turns to red when the tags are zapped with an intense pulse of visible blue light.

The dramatic color change "makes it possible to precisely label an object, such as a cell, organelle, or protein, with a flash of light and then to follow the object's movement over time," said Konstantin Lukyanov, whose group conducted the Dendra research in the lab of his brother, Sergey Lukyanov, a Howard Hughes Medical Institute (HHMI) international research scholar at the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences in Moscow. "This tool opens new possibilities for studying protein and organelle dynamics in living cells, cell migration during embryogenesis, inflammation, and other pathological and normal processes," he said.

Unlike other green-to-red fluorescent markers, Dendra can be activated by visible blue light, which is less harmful to living cells and does not require special laser equipment, Konstantin Lukyanov explained. In fact, the light source of the laser-scanning confocal microscopes that researchers commonly use to peer into living cells can activate the tag, which should make the new tool useful to many scientists, said Sergey Lukyanov, whose lab reports on the Dendra tag in the April 2006 issue of Nature Biotechnology, published in advance online on March 19, 2006.

Importantly, Dendra is small enough to highlight proteins without interfering with their folding or function. And the resea
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Old drug, new tricks: Prospects for slashing the impact of malaria
2. Dangerous tricksters: Some bacterie use immune cells to reproduce
3. Researchers use trickery to create immune response against melanoma
4. New finding points way to foiling anthraxs tricks
5. A wolf in sheeps clothing: Plague bacteria reveal one of their virulence tricks
6. An AIDS-related virus tricks cells to become tumors, new Penn study finds
7. Scientists perform tricky operation
8. Yale biologists trick viruses into extinction
9. Toxoplasmosis infection trick revealed by scientists
10. Jumping gene helps explain immune systems abilities
11. Protein helps regulate the genes of embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sea coral trick helps scientists tag proteins

(Date:3/17/2015)... Minn. , March 17, 2015 ... technology company specializing in clinical study management systems, ... be in attendance at ARENA,s Outsourcing in Clinical ... NC.  This event provides an excellent forum for ... easy-to-use, flexible and affordable software-as-a-service (SaaS) eClinical technology ...
(Date:3/17/2015)... 2015  MecklerMedia Corporation (OTCQX: MECK) announced its ... robots ever held in New York ... 11-13, 2015 at the Javits Convention Center. ... include: Acorn Product Development; Axis NJ; c-Link Systems; ... Littler; NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; ...
(Date:3/12/2015)... Va. , March 12, 2015 IriTech, ... and a member of the Texas Instruments Design Network, ... Naidu has demonstrated its IriShield USB MK2120U device ... scanning facility for pension distribution. The ... assembled to be marketed in India ...
Breaking Biology News(10 mins):Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3
... -- The Society of American Foresters has named Louisiana ... Director A. Gordon Holley as its 2012 Carl Alwin ... the 2012 Society of Foresters National Convention held Oct. ... outstanding performance in the field of forestry education. This ...
... . . . U.S. Forest Service and ... levels of ozone may amplify the impacts of higher ... and other water bodies. Such effects could potentially reduce ... in the southeastern United States. Using data on atmospheric ...
... A team led by researchers at the University of ... "superbug" methicillin-resistant Staphylococcus aureus (MRSA) is prevalent ... well known for causing difficult-to-treat and potentially fatal bacterial ... it has also been infecting otherwise healthy people in ...
Cached Biology News:Louisiana Tech University professor earns national honor from Society of American Foresters 2November 2012 story tips 2Superbug MRSA identified in US wastewater treatment plants 2
(Date:4/1/2015)... (PRWEB) April 01, 2015 The concept of ... a multi-billion dollar industry. Founder of Fasciology, Ashley Black, says ... area of fat, instead of having to wait for the ... claims that “ prior to fat cooling procedures, the ... or contouring, was liposuction, which is a highly invasive procedure.” ...
(Date:4/1/2015)... Immunocore Limited ("the Company"), ... to treat cancer, viral infections and autoimmune disease, ... Christina Coughlin as Chief Medical Officer. ... and regulatory leadership to the pre-clinical and clinical ... has extensive experience in oncology drug development, with ...
(Date:3/31/2015)... VANCOUVER , March 31, 2015  /PRNewswire/ - ESSA ... today that it has filed with the Food and ... Drug ("IND") application related to the Company,s proposed clinical ... the IND application is required in order for ESSA ... The IND application is a complete ...
(Date:3/31/2015)... Pittcon 2015, the 66th Conference and Exposition ... 12, in New Orleans with an economic impact to ... the New Orleans Convention and Visitor's Bureau. This global ... personnel. Those who attended Pittcon for the first-time ... third year, the co-location of Food Labs Conference, organized ...
Breaking Biology Technology:Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 2Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 3Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 2Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 3Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 4ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 2ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 3ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 4Pittcon 2015 Hits the Big Easy in a Big Way 2Pittcon 2015 Hits the Big Easy in a Big Way 3Pittcon 2015 Hits the Big Easy in a Big Way 4
... , , PHILADELPHIA and LONDON, Aug. ... the National Institutes of Health (NIH) has chosen Web of ... ( eSPA ). eSPA is an information technology system ... and tracking research outputs and outcomes, including publications and citations. , ...
... 3 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ... relating to long-term treatment with Stimuvax were presented at ... 13th World Conference on Lung Cancer in San Francisco ... Goss from the Ottawa Hospital Cancer Centre, Ottawa, Ontario, ...
... BEIJING, Aug. 3 /PRNewswire-Asia-FirstCall/ -- Yongye ... a leading developer and,distributor of Shengmingsu branded plant and ... today announced that the number of,independently owned, branded stores ... of June 30, 2009, up from 3,500,as of the ...
Cached Biology Technology:National Institutes of Health Chooses Web of Science(R) to Power electronic Scientific Portfolio Assistant (eSPA) 2Oncothyreon announces presentation of long-term Stimuvax data at World Conference on Lung Cancer 2Oncothyreon announces presentation of long-term Stimuvax data at World Conference on Lung Cancer 3Oncothyreon announces presentation of long-term Stimuvax data at World Conference on Lung Cancer 4Yongye International Announces Branded Store Network Increases Over 40% to 5,000 Stores 2Yongye International Announces Branded Store Network Increases Over 40% to 5,000 Stores 3
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selecitivty and potential CNS-Side Effect liabilities of compo...
... Sets contain the basic components and ... sandwich ELISA plates for quantitation of ... of cell culture supernate. Every Screening ... Recombinant Standard (5 individual standards), Streptavidin-HRP, ...
... The organic acid analysis standard ... six organic salts; molecular weights ... This standard is provided for ... column and the organic acid ...
... a particle shape and size analyzer offering a ... the utmost simplicity in mind. It is comprised ... an optical bench. The system is completely computer ... for different applications such as dry or where ...
Biology Products: