Navigation Links
Scientists seek answers on what activates deadly anthrax spores

Scientists at Wake Forest University Baptist Medical Center and three other institutions are setting out to find what activates the spores in anthrax, the deadly bacterial infection that is back in the news.

"A key aspect of anthrax spore biology concerns the germination process through which the dormant spore becomes a reproductive, disease-causing bacterium," explained Al Claiborne, Ph.D., the principal investigator. "The potential importance of such a germination control mechanism in anthrax is clear, as spore germination and outgrowth are fundamental to proliferation."

Claiborne, co-director of Wake Forest's Center for Structural Biology, added, "Basic understanding of the regulatory signals that promote germination will enable discoveries leading to drugs that block the process."

The research is being paid for by a $152,687 grant from the Southeast Regional Center of Excellence in Biodefense and Emerging Infections, based at Duke University, one of eight such regional centers funded by the National Institute of Allergy and Infectious Diseases.

The other institutions in Claiborne's project include a co-investigator at Virginia Tech and collaborators at the U.S. Army Medical Research Institute of Infectious Diseases in Frederick, Md, and the University of California, San Diego.

The research stems from lessons learned from studying the bacteria that cause Staphylococcus infections and two other bacteria in the same group as anthrax.

Claiborne said the group proposes that a vitamin B5 derivative known as Coenzyme A plays a crucial role in the germination of the anthrax spores. They have already shown that anthrax is missing a similar cofactor called glutathione that is common to many other bacteria, as well as humans.

The researchers are working with a non-pathogenic strain of anthrax. The genome sequences of four strains of the bacteria, known scientifically as Bacillus anthracis, have been determined.

'"/>

Source:Wake Forest University Baptist Medical Center


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
6. Scientists collaborate to assess health of global environment
7. Scientists decipher genome of fungus that can cause life-threatening infections
8. Scientists discover the cellular roots of graying hair
9. Scientists rid stem cell culture of key animal cells
10. Scientists develop new color-coded test for protein folding
11. Scientists identify genetic pathways essential to RNA interference
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists seek answers what activates deadly anthrax spores

(Date:5/8/2015)... -- Synaptics Inc. (NASDAQ: SYNA ), the leading developer ... executive management team will present at the following investor events: ... Conference Date: May 18, 2015 Time: 10:40am ET ... Cowen and Company Technology, Media & Telecom ... New York Palace Hotel, New York, NY ...
(Date:4/27/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® Smart ... week of May, 2015 and will be fulfilling all ... Gino Pereira , Chief Executive Officer said, ... Wocket® enters the consumer market. We would like to ...
(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... a new understanding of how male puberty begins. ... known as SMAD3 and the rate at which it is ... the Faculty of Medicine, Nursing and Health Sciences have discovered ... in faster maturation than the norm, and an inability to ...
... genius is a byproduct of good genes or good environment ... an entirely new direction. University of Alberta researcher Marty Mrazik ... of a natural hormone. Mrazik, a professor in the ... Rider University in the U.S., have published a paper in ...
... a team of Spanish and Greek researchers, and published in the ... than 30% of the hake products sold in Spain and Greece ... Africa are being labelled as American or European, meaning consumers pay ... the University of Oviedo (Spain) and co-author of the study, tells ...
Cached Biology News:Monash scientists uncover a new understanding of male puberty 2U of A researcher questions whether genius might be a result of hormonal influences 2Around 40 percent of hake is mislabeled 2
(Date:5/26/2015)... REDWOOD CITY, California and HILDEN, ... -- QIAGEN N.V. (NASDAQ: QGEN ... commercial launch of its QIAGEN Clinical Insight ® ... clinical testing labs to interpret and report on ... first two supported applications for the bioinformatics platform ...
(Date:5/26/2015)... Global Stem Cells Group and Stem ... first cellular and regenerative medicine symposium in Barcelona Spain ... stem cell training class Oct. 10. The event will ... of Therapeutic Confrontations (CONFTERA) in Barcelona. , In ... medicine and recent advances in cellular therapies, Global Stem ...
(Date:5/26/2015)... 26, 2015 Leading Regenerative Veterinary ... a long-term relationship with Veterinary Growth Partners, a ... members to provide access to vital services to ... count VGP as a dedicated partner in bringing ... nationwide. Concentrating and using stem cells natural abilities ...
(Date:5/26/2015)... , May 26, 2015 /PRNewswire/ - Fluorinov Pharma (Fluorinov), ... Luke M. Beshar to its Board of ... and pharmaceutical industry expertise as Fluorinov accelerates its clinical ... Fluorinov team, it is a pleasure to welcome Luke ... significant impact on the strategy, financial strength and success ...
Breaking Biology Technology:QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 4QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 5Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 3VetStem Biopharma & Veterinary Growth Partners Join Forces to Increase Member Veterinary Hospital Revenue Through Cutting Edge Medical Offering 2VetStem Biopharma & Veterinary Growth Partners Join Forces to Increase Member Veterinary Hospital Revenue Through Cutting Edge Medical Offering 3Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 2Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 3
... BETHESDA, Md., Sept. 16 American Capital Ltd. ... 15, it completed the sale of its portfolio company Axygen ... Inc., to Corning Incorporated for approximately $400 million. The ... fee income, from the equity invested by American Capital,s affiliated ...
... , , COLUMBIA, Md., Sept. 16 Martek ... David M. Pernock to its Board of Directors. , ... extensive background in the commercialization of pharmaceutical products, having served from ... (GSK), one of the world,s leading healthcare companies. In his most ...
... HEIDELBERG, Germany, September 16 , ... Drug Targets in Wnt Pathway , ... antagonizes Wnt signalling"** is now available online in,Nature. , ... proteomics,platform was used to identify a small molecule which plays ...
Cached Biology Technology:American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 2American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 3American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 4Martek Announces Addition to Its Board of Directors 2Cellzome Technology Used to Unravel Novel Regulatory Mechanism in Cancer Signaling Pathway 2
50 assays. Provides an easy system for rapid separation of cytosol and particulate fractions that are compatiable with downstream studies....
Eliminate electrical interference from any analog signal, without filtering. Ideal for electrophysiology applications like EKG, EMG, and EEGs. Removes 50/60hz noise and harmonics caused by grounding ...
... 400 Spun Columns, 10. *SizeSep 400 Spun ... 400 base pairs in length. - ... and pre-equilibrated in distilled water containing 0.15% Kathon ... ~ 400 base pairs. *Extremely useful ...
... CyScribe GFX Purification Kit, 25 ... CyDye labeled cDNA probesProvides efficient removal ... from labeling reactions with superior yields ... for the purification of cDNA labeled ...
Biology Products: