Navigation Links
Scientists reveal molecular secrets of the malaria parasite

In an innovative project with implications for malaria vaccine development, scientists have used genomics, proteomics and gene expression studies to trace how malaria parasites evolve on a molecular level as they move between their hosts and insect vectors. That focus on the parasites' complex life cycle is helping researchers understand when different genes switch on and off as the pathogens metamorphose through seven different life stages. In turn, that molecular-level data may benefit biomedical scientists who are identifying new targets for vaccines that would impede the parasite during stages when it is particularly vulnerable to intervention.

"We hope this project will help vaccine researchers find the best targets against malaria," says scientist Neil Hall, the first author of the paper that appears in the January 7th issue of Science. "The study's findings will help scientists identify parasite genes that are interacting with the host as well as new gene targets for vaccines that aim to prevent parasite transmission in the mosquito." The study highlights the genes in four malarial species that evolve rapidly because of "selective pressures" in the stages of their life cycles in their mosquito vectors and in their mammalian hosts. Malaria parasites undergo three stages in their mosquito vectors, three stages in their vertebrate hosts and a sexual development stage during which the parasite is transmitted between vector and host. The Science paper represents the culmination of four years of cooperative work by scientists at several research institutes, including: the Wellcome Trust Sanger Institute in the U.K., where the sequencing and genome annotation was performed on two species of rodent malaria (Plasmodium chabaudi and P. berghei); the University of Leiden in the Netherlands and Imperial College in England, where scientists carried out gene expression studies; and The Institute for Genomic Research (TIGR), in Maryland, where scientists did a compa
'"/>

Source:Eurekalert


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists reveal molecular secrets the malaria parasite

(Date:11/21/2014)... JOSE, Calif. , Nov. 20, 2014   ... global leader in microcontroller (MCU) and touch technology solutions, ... digital temperature sensors with the widest V cc ... delivers higher temperature accuracy and faster I 2 C ... registers and serial EEPROM memory making them ideal for ...
(Date:11/15/2014)... we may still be a few years away from the ... gain instant access to all that ailed his patients, mobile ... for monitoring and measuring our health are cropping up in ... tad Orwellian to some, but a new survey suggests that ... into their healthcare regime. These are some of ...
(Date:11/7/2014)... Nov. 7, 2014  In conjunction with the ... Departments, The Community Foundation of the Verdugos has announced the ... JUSTICE PROJECT," a $250,000 initiative to keep the Verdugo Regional ... its first six months of existence, the Lab has processed ... for local law enforcement. "Because our number one ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... at the University of North Carolina at Chapel Hill have ... programmed cell death or apoptosis. This molecule, a tiny ... shown to be in short supply in certain neurodegenerative illnesses ... could herald a new treatment to prompt brain cells to ...
... lower total and LDL (low-density lipoprotein or "the ... mechanism whereby soy protein lowers cholesterol remains unresolved. ... of Clinical Lipidology last month shows that ... lipoprotein) cholesterol significantly more than milk protein in ...
... even though their close relatives rays and chimaeras have ... Nathan Scott Hart and colleagues from the University of ... Their study shows that although the eyes of sharks ... only have a single long-wavelength-sensitive cone* type in the ...
Cached Biology News:New molecule could save brain cells from neurodegeneration, stroke 2New molecule could save brain cells from neurodegeneration, stroke 3New study shows soy protein lowers non-HDL cholesterol significantly more than milk protein 2Are sharks color blind? 2
(Date:11/22/2014)... The “Chiral Chromatography Columns Market by type (Empty, ... by Application [GC, LC (HPLC, UHPLC, Flash Chromatography, ... and studies the major market drivers, restraints, opportunities, ... Rest of the World. , Browse 90 market ... pages and in-depth TOC on “Chiral Chromatography Columns ...
(Date:11/22/2014)... , November 21, 2014   ... als Chief Commercial Officer zu KLOX    ... Unternehmensentwicklung und Chief Financial Officer bestellt    ... der Vermarktung seines jüngst zugelassenen Behandlungssystems zur Wundheilung zu ... bzw. das "Unternehmen") ist sehr erfreut, die folgenden personellen ...
(Date:11/21/2014)... The science of light and how it ... than 200 primary students in a traveling program organized ... Otago Physics Department and funded by an SPIE ... the university’s OSA/SPIE Student Chapter visited six primary schools ... from small, rural schools hands-on lessons in optics and ...
(Date:11/21/2014)... Palo Alto, Calif. (PRWEB) November 20, 2014 ... (CHI), a nonprofit, public policy research organization representing ... and pharmaceutical firms, and PwC US ... other states in life sciences industry growth. The ... and 2013. The 2015 California Biomedical Industry ...
Breaking Biology Technology:Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4
... Co., Ltd., and its parent company, Otsuka Holdings Co., ... for Human Use (CHMP), a division of the European ... of Teysuno™ (S-1), a novel oral anti-cancer agent, intended ... when given in combination with cisplatin. The Committee will ...
... Catal de Nanotecnologia (ICN), in Barcelona, has demonstrated a device ... key step in developing the spin computers of the future. ... the journal Science. The authors are Marius V. Costache and ... the Physics and Engineering of Nanodevices Group at ICN. ...
... Quest Diagnostics (NYSE: DGX ), the ... services, today announced that its Care360™ Electronic Health ... was certified as a Complete EHR on Wednesday, ... eligible Health Information Technology (CCHIT®), an ONC-ATCB, in ...
Cached Biology Technology:Teysuno™ (S-1) Receives CHMP Positive Opinion for Approval as First-Line Therapy for Advanced Gastric Cancer 2Teysuno™ (S-1) Receives CHMP Positive Opinion for Approval as First-Line Therapy for Advanced Gastric Cancer 3Teysuno™ (S-1) Receives CHMP Positive Opinion for Approval as First-Line Therapy for Advanced Gastric Cancer 4A 'spin ratchet': A new electronic structure for generating spin current 2Quest Diagnostics® Care360™ EHR Receives ONC-ATCB 2011/2012 Certification 2Quest Diagnostics® Care360™ EHR Receives ONC-ATCB 2011/2012 Certification 3Quest Diagnostics® Care360™ EHR Receives ONC-ATCB 2011/2012 Certification 4
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
TXNL2 Antibody...
Mouse monoclonal [3F8 ] to smooth muscle Myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: P35749...
Request Info...
Biology Products: