Navigation Links
Scientists identify molecular events that drive cell senescence

UT Southwestern Medical Center at Dallas researchers have found a way of stimulating the immune systems of mice to fight against amyloid proteins that cause the devastating plaques that are characteristic of Alzheimer's disease. For years scientists have examined the possibility of using a protein-based vaccine to slow the progression of the disease in its early stages. UT Southwestern researchers have created a gene-based vaccine aimed at stimulating the immune systems of mice to potentially fight off plaque-causing amyloid protein in the brain. Their findings appear in today's issue of the Archives of Neurology.

"Previous Alzheimer's vaccines were protein-based," said Dr. Baoxi Qu, the study's lead author and assistant professor in the Center for Biomedical Inventions and internal medicine. "We wanted to try a DNA-based genetic vaccine instead to see if we could enhance the immune response." Although prior studies of amyloid protein vaccination had shown some slowing in the plaque buildup, negative side effects also occurred in a handful of patients. Some had autoimmune responses that caused encephalitis. The key in the UT Southwestern study was finding another way to vaccinate patients without stimulating the body's own immune cytotoxic T cells, said Dr. Roger Rosenberg, a study author and director of the Alzheimer's Disease Center. "This dilemma was discussed with my colleagues, and we decided to try vaccination with an amyloid gene, rather than the amyloid protein vaccine," said Dr. Rosenberg. The UT Southwestern researchers vaccinated mice with a "gene gun." The gene gun and gene-vaccination technologies were invented by Dr. Stephen Albert Johnston, director of the Center for Biomedical Inventions and senior author of the latest study. "We have been developing ways to use gene-immunization to manipulate the immune response," Dr. Johnston said. "This study was the first step to see if we can apply these techni
'"/>

Source:


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:2/25/2015)... 2015  ABC Financial Services (ABC), the leading ... and Fitness Industry, today announced enhancements to their ... latest upgrade includes advances to the agreement section ... via Identity One fingerprint biometrics. The features will ... displays at the International Health, Racquet & Sportsclub ...
(Date:2/24/2015)... 2015 This report analyzes the worldwide markets for Face ... Biometrics, and Voice Biometrics. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific , ... , and Latin America . Annual estimates and ... seven-year historic analysis is provided for these markets. Market data and ...
(Date:2/23/2015)... , Feb. 23, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... provisional patent 62114357 for DISTRIBUTED VOICE DIRECTED ... NXT-ID introduces a new groundbreaking payment method. Payment accounts ... account may only be accessed if both the speech ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3
... LANSING, Mich. The discovery of a new gene ... by Michigan State University and appearing on the cover ... of Sciences , demonstrates that domestic tomatoes could re-learn ... Long-term cultivation has led to tomato crops losing beneficial ...
... GSA Bulletin papers posted online from 20 July ... Mexico, Spain, Turkey, Nova Scotia, Switzerland, New Mexico, and ... the Moho, age dating using zircon crystals, the Code ... GSA Bulletin articles published ahead of ...
... University have found identical strains of antibiotic-resistant ... ) in both antibiotic-free (ABF) and conventionally raised ... pathogens can persist and thrive in the environment, ... Dr. Siddhartha Thakur, assistant professor of population health ...
Cached Biology News:New gene could lead to better bug-resistant plants 2Summer Geoscience from GSA Bulletin 2Summer Geoscience from GSA Bulletin 3Summer Geoscience from GSA Bulletin 4Summer Geoscience from GSA Bulletin 5Summer Geoscience from GSA Bulletin 6Summer Geoscience from GSA Bulletin 7Summer Geoscience from GSA Bulletin 8Summer Geoscience from GSA Bulletin 9Summer Geoscience from GSA Bulletin 10Summer Geoscience from GSA Bulletin 11Summer Geoscience from GSA Bulletin 12Summer Geoscience from GSA Bulletin 13Summer Geoscience from GSA Bulletin 14Summer Geoscience from GSA Bulletin 15Antibiotic-resistant pathogens persist in antibiotic-free pigs 2
(Date:3/2/2015)... Global Stem Cells Group.com ... HANK Bioengineering Co., Ltd. and its Chinese-American founder ... a stem cells training course in the City ... , Shenzhen HANK is a biotechnology company established ... and virologist, to integrate research, development, production, and ...
(Date:3/1/2015)... March 01, 2015 Market Publishers ... for quality market research promotion on Internet. MarketPublishers.com ... reports worked out by DataGroup Booksellers. , Natalie ... Publishers Ltd, commented on the recent partnership agreement ... Booksellers in our team of publishers. Since 1974, ...
(Date:2/27/2015)... Halifax, Nova Scotia (PRWEB) February 27, 2015 ... has been made aware of a fraudulent press release ... GlobeNewswire, purporting to be from Immunovaccine. This press release ... with Gilead Science, Inc. The press release did ... to the information contained within the press release. ...
(Date:2/27/2015)... Calif. , Feb. 27, 2015  Pharmacyclics, ... that longer-term toxicology studies for its newly developed ... or RA, have been completed. The results of ... U.S. Food and Drug Administration. The feedback received ... of the ongoing first-in-human study. Additional preclinical work ...
Breaking Biology Technology:Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 2Market Publishers Ltd and DataGroup Booksellers Sign Partnership Agreement 3Immunovaccine Disclaims Hoax Press Release 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 3
... Wis. Emergency vehicle drivers have a new way ... Electronic Devices dashboard video screens. Replacing the traditional series ... than seven inches, HED has attempted to streamline controls while ... pay attention to, said Keith Schmitz of the Schmitz ...
... The television ad in which George Bush and Bill Clinton urge ... only because the appeal comes from two former presidents, but because ... e-relief has dawned. , ,Bush and Clinton point viewers to the ... helping to coordinate the millions of dollars that have streamed in ...
... Hamlet: Do you see that cloud, thats almost in shape ... a camel, indeed. ,Hamlet: Methinks it is like a weasel. ... a whale? ,Polonius: Very like a whale. , Hamlet ... Shakespeare) , ,Occasionally stumbling across truth but mostly skilled ...
Cached Biology Technology:Hartford firm brings video to the dashboard 2Hartford firm brings video to the dashboard 3Outpouring of tsunami relief displays power of the Internet 2Outpouring of tsunami relief displays power of the Internet 3Follow these three rules when choosing tech consultants 2Follow these three rules when choosing tech consultants 3Follow these three rules when choosing tech consultants 4
... The Chromo4 real-time PCR detector is an ... on a DNA Engine or Dyad Disciple ... includes a compact scanning photonics shuttle that ... nm, 500-535 nm, 555-585 nm, 620-650 nm) ...
... are highly sensitive laser confocal systems designed ... advanced scanners that meet your expectations, differentiating ... and optimizing the signal on the bottom ... the range for increased sensitivity. Results with ...
... on four slides. The new ArraySlide 24-4 ... (6mm x 7mm) individual printing surfaces for ... analysis studies. Unlike other systems, this device ... presence of contaminating adhesives. The chamber itself ...
... 3 nmol (individual) with sequence siTrio ... targeted to your target gene of interestis our ... get more than 75% knockdown of your target ... siRNA for transfection and confirmation of optimal transfection ...
Biology Products: