Navigation Links
Scientists find missing enzyme for tuberculosis iron scavenging pathway

his colleagues have discovered that the enzyme most likely plays an entirely different role in M. tuberculosis.

"What the structure showed, when combined with careful analysis of the sequence, its neighbors in the genome, and the fact that its gene was also regulated by iron, was that Rv1347c was almost certainly a "missing enzyme" from the pathway for biosynthesis of the iron scavenging agent mycobactin," recalls Dr. Baker.

"Mycobactin is a small molecule which binds iron very tightly. Bacteria synthesize it so that they can acquire the iron they need to grow ?it is secreted out into the external environment where it scavenges iron and then (with iron bound to it) it is taken up by the bacterium again."

Although Rv1347c is not involved in antibiotic resistance, it still remains a target for the design of new anti-TB drugs. "Enzymes that synthesize mycobactin are drug targets, because if mycobactin biosynthesis is stopped, the bacterium cannot acquire the iron that it needs for survival," explains Dr. Baker. "Importantly this seems to be true even of the bacteria that are taken up by macrophages in the lung and enter a dormant state ?these are the hardest to attack with drugs."


'"/>

Source:American Society for Biochemistry and Molecular Biology


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists seek answers on what activates deadly anthrax spores
5. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
6. Scientists collaborate to assess health of global environment
7. Scientists decipher genome of fungus that can cause life-threatening infections
8. Scientists discover the cellular roots of graying hair
9. Scientists rid stem cell culture of key animal cells
10. Scientists develop new color-coded test for protein folding
11. Scientists identify genetic pathways essential to RNA interference
Post Your Comments:
(Date:3/30/2015)... Research and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) ... Recognition Market in Automotive Sector 2014-2018" report to ... Gesture Recognition market in Automotive Sector to grow at ... Gesture recognition is the ability of a device ... individual. Gesture recognition technology can be 2D-based or 3D-based. ...
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
(Date:3/23/2015)... SoundView Technology Group issues a new research update ... Wocket smart wallet. SoundView was one of the selected user groups ... the Wocket in multiple scenarios and outlets. ... retailers, making both debit and credit card payments.  ... the company meets their plans in 2015, it would push ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... respond to a potential national health emergency, scientists have ... the possible future course of an avian influenza pandemic, ... a team of scientists from Los Alamos National Laboratory ... Fred Hutchinson Cancer Research Center in Seattle, is presented ...
... are far more important to the global ocean's biosphere ... may not have the scientific allure of tropical reefs ... that the woody coastline-dwelling plants provide more than 10 ... to the global ocean from land, according to a ...
... who overexert themselves running or playing basketball may one day ... Jerusalem that shows that adult stem cells can be used ... and ligament injuries present a major clinical challenge to orthopedic ... undergo tendon or ligament repair each year. Moreover, the intervertebral ...
Cached Biology News:Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic 2Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic 3Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic 4The critical importance of mangroves to ocean life 2Stem cells can repair torn tendons or ligaments 2
(Date:5/4/2015)... 4, 2015 /PRNewswire/ - The Fight Against Cancer ... to announce the formation of Turnstone Biologics Inc. ... for cancer that harness the patient,s own immune ... collaboration between the Children,s Hospital of ... University, the Ontario Institute for Cancer Research (OICR), ...
(Date:5/4/2015)... -- Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the Company), a ... needs in the areas of inflammation, oncology and biodefense, ... from three of its biodefense programs at the upcoming ... May 12-14, 2015 to be held at the America,s ... St. Louis MO 63101. The ...
(Date:5/4/2015)... GERMANTOWN, Md. , May 4, 2015   ... it will release first quarter 2015 financial results after ... will host a conference call that day at 5:30 ... general business update. The conference call may ... (International) and asking to join the "Intrexon Conference Call."  ...
(Date:5/1/2015)... (PRWEB) May 01, 2015 OncoTAb, ... (UNC Charlotte) spin-out company, announced that Pinku Mukherjee, Ph.D. ... the UNC Board of Governors’ highest faculty honor. Mukherjee ... humanity’s welfare , for her innovative research and development ... Gardner Award represents a crowning moment in my scientific ...
Breaking Biology Technology:Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 2Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 3Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 4Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 5Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 6Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 7Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 8Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 9Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 10Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 11Soligenix Announces Presentation and Poster at the 2015 Chemical and Biological Defense Science and Technology Conference in St. Louis, MO 12Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2
... ... particle size distribution technology in the particle characterization and material sciences category. The ... Germany. , ... May 18, 2010 -- The Powtech/TechnoPharm jury awarded METTLER TOLEDO the Innovation Award 2010 ...
... ... less smelly, thanks to a new indoor composting kit from SCD Probiotics. ... an airtight bucket. Bokashi, made using SCD,s probiotic technology, helps accelerate the process and ... ...
... May 18 Caliper Life Sciences, Inc. (Nasdaq: CALP ... life sciences research, today announced that it reached an agreement to sell ... product lines to Biotage AB for $16.5 million in cash. ... "Divesting these product ...
Cached Biology Technology:FBRM C35 In-Process Particle Characterization Technology Receives Powtech/TechnoPharm Innovation Award 2010 2FBRM C35 In-Process Particle Characterization Technology Receives Powtech/TechnoPharm Innovation Award 2010 3All Seasons Indoor Composter™ and All Seasons Bokashi™ Provide Easy Way to Recycle Food Waste Right in Your Kitchen 2All Seasons Indoor Composter™ and All Seasons Bokashi™ Provide Easy Way to Recycle Food Waste Right in Your Kitchen 3Caliper Enhances Strategic Focus and Increases Growth Capital with Sale of Product Lines to Biotage 2Caliper Enhances Strategic Focus and Increases Growth Capital with Sale of Product Lines to Biotage 3Caliper Enhances Strategic Focus and Increases Growth Capital with Sale of Product Lines to Biotage 4
Physical Form: saline suspension with ethanol Particle Dim: mean particle size 50 μm Matrix: HyperD F. Useful for the removal of detergents from protein samples....
SDS-OutT SDS Precipitation Reagent...
... The Sciclone inL10 Workstation from Caliper ... technology, offering for the first time the ... to automatically react to changing conditions. ... changes in viscosity due to changes in ...
... Series of systems provide fast and ... discovery, genomics, proteomics and drug development ... three base configurations; Mini Workstation Series, ... All Staccato Application Series systems ...
Biology Products: