Navigation Links
Scientists document complex genomic events leading to the birth of new genes

A team of scientists led by Peer Bork, Ph.D., Senior Bioinformatics Scientist at the European Molecular Biology Laboratory, report today in the journal Genome Research that they have identified a new primate-specific gene family that spans about 10% of human chromosome 2. Comprised of eight family members, the RGP gene cluster may help to explain what sets apart humans and other primates from the rest of the animal kingdom.

Human chromosome 2 has always intrigued primate biologists; it formed from the fusion of two mid-sized ape chromosomes and is the only cytogenetic distinction separating humans from apes. At the molecular level, however, the differences among the species are much more complex.

Bork's team systematically searched the complete genomic sequences from a broad range of taxa (mouse, rat, roundworm, fruit fly, mosquito, and pufferfish) for single-copy genes that had evolved more than one copy in humans. "Gene duplication is known to play a leading role in evolution for the creation of new genes," explained Francesca Ciccarelli, Ph.D., lead author on the study. The key to this, however, is that the duplicated copies of genes very quickly evolve functions that are significantly different than those of their progenitors.

Natural selection acts on gene duplications, most often by deleting them from the gene pool or by degrading them into non-functional pseudogenes. This is because fully functional duplicated genes, in combination with the corresponding parent gene, produce abnormally abundant quantities of transcripts. This overexpression often alters the fragile molecular balance of gene products on a cellular level, ultimately resulting in deleterious phenotypic consequences. If these duplicated genes acquire new functions, however, they may confer a selective advantage to an organism, leading to the rise of lineage-specific genes over evolutionary time.

Bork's team identified a total of 22 genes with more than one co
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:9/18/2014)... Americans to undertake jaunts into the countryside each year could ... a century, according to new research. , Climate change could ... States as summer temperatures linger later into the year, Princeton ... Biogeography . For instance, the paper birch a popular ... could change color one to three weeks later by ...
(Date:9/18/2014)... in DNA, tiny strands of nucleic acid that contain ... this genetic data, our DNA is copied into RNA ... perform tasks in our cells. , Several years ... Unlike all other known RNAs, this molecule is circular, ... abundant, little has been known about how they are ...
(Date:9/18/2014)... Sept. 18, 2014 -- Arizona turned its newborn screening program ... few short months, earning it the first-ever Newborn Screening Quality ... of Dimes presented Will Humble, M.P.H., Arizona,s Department of Health ... today. Mr. Humble established a policy of full transparency for ... newborn blood samples to the lab for analysis, and set ...
Breaking Biology News(10 mins):Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3
... of a besotted male and beer. Love-sick and lonely, the male ... but with a surprising outcome, as a U of T ... jewel beetle ( Julodimorpha bakewelli ), became so enamored with a ... so vigorously that he died trying to copulate in the ...
... Jolla----Ever wondered why you wake up in the morning ---- ... no more. Researchers at the Salk Institute for Biological Studies ... gene responsible for starting the clock from its restful state ... early each day, initiating important physiological functions that tell our ...
... This press release is available in German . ... may be up to 45 per cent more than previously thought. ... on the variability of heavy oxygen atoms in the carbon dioxide ... oxygen atoms in carbon dioxide were converted faster than expected during ...
Cached Biology News:University of Toronto Mississauga professor wins Ig Nobel Prize for beer, sex research 2'Alarm clock' gene explains wake-up function of biological clock 2'Alarm clock' gene explains wake-up function of biological clock 3Productivity of land plants may be greater than previously thought 2Productivity of land plants may be greater than previously thought 3
(Date:9/20/2014)... MediVet America and NanoFiber Veterinary ... at the specialized Wolvega Horse Clinic. , Due to ... was ruptured 90% and her deep digital flexor tendon ... sentence for a horse. , The clinic has performed ... This revolutionary regenerative option for ruptured tendons has ...
(Date:9/19/2014)... light, rather than electricity, to move data would ... is a growing concern as chips, transistor counts ... optical circuits light emitters, modulators, and detectors ... promising light source for optical chips is molybdenum ... deposited as a single, atom-thick layer. Other experimental ...
(Date:9/19/2014)... , Sept. 19, 2014  Nektar Therapeutics ... from preclinical studies characterizing the analgesic profiles of ... kappa opioid receptor agonist molecules. The preclinical research ... medicinal chemistry platform. The analgesic properties ... the medical literature. 1,2 Kappa opioid receptors ...
(Date:9/19/2014)... Minnesota (PRWEB) September 19, 2014 ... related food industries will gather October 5–8, 2014, ... the Rhode Island Convention Center in Providence, Rhode ... feature the work of food scientists, chemists, microbiologists, ... control, and food production management. To date, 1,000 ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Toward optical chips 2Toward optical chips 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3
... 30 Nabi,Biopharmaceuticals (Nasdaq: NABI ) (the ... Lewis & Co., two of the nation,s leading,independent ... vote "FOR" the Company,s proposed sale of its ... assets to Biotest,Pharmaceuticals Corporation, a wholly owned subsidiary ...
... Fla., Oct. 30 Pasteuria Bioscience, Inc., (http://www.pasteuriabio.com ... for agriculture,s largest unmet pest problem, announced,today that ... the new Chief,Executive Officer. Dr. Duncan has also ... succeeds Dr. Kelly Smith who will remain active ...
... DNDN ) today announced that management will present at the,following ... 9th Annual Healthcare Conference The New York Palace Hotel ... JMP Securities Healthcare Focus Conference Four Seasons Hotel Boston ... Lazard Capital Markets Fourth Annual Healthcare Conference The New ...
Cached Biology Technology:RiskMetrics Group (ISS) and Glass Lewis & Co. Support Nabi Biopharmaceuticals' Proposed Asset Sale 2RiskMetrics Group (ISS) and Glass Lewis & Co. Support Nabi Biopharmaceuticals' Proposed Asset Sale 3Pasteuria Bioscience Taps New CEO David N. Duncan 2Pasteuria Bioscience Taps New CEO David N. Duncan 3
Active GST Protein...
... Cyno Serum • Cyno serum is collected off ... and 5-7 years of age. Available Anticoagulants: ... (Na) N-06: K2EDTA N-08: Potassium ... Alsevers N-05: ACD N-07: CPD ...
All serum is collected from adult animals aged 6 months or older. Certified U.S. orgin. Pricing: $35/unit for 1 - 10 units...
adult...
Biology Products: