Navigation Links
Scientists discover way to block growth of prostate cancer cells

Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.

They found that a drug that blocks this pathway significantly prolonged survival and inhibited tumour development in mice that were genetically engineered to spontaneously develop prostate cancer and die of the disease. The hope is that this drug could be used eventually to treat men at high risk of developing prostate cancer and to prevent recurrences in men already treated for primary tumours.

Dr Hirak Basu told a news briefing at the EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Prague today (Wednesday 8 November): "Previous work has demonstrated that androgen treatment increased reactive oxygen species levels in androgen-dependent prostate cancer cells, but, until now, the pathway involved was unknown."

Dr Basu is an associate scientist and principal investigator in the Prostate Cancer Group at the Paul P. Carbone Comprehensive Cancer Center, Madison, WI, USA. He and his collaborators at the centre found that levels of a key enzyme, spermidine/spermine acetyl transferase (SSAT), which starts oxidation of polyamines, rose markedly when prostate cancer cells were treated with androgen. Polyamines are small molecules produced in large quantity by the prostate gland and are secreted in the seminal fluid. Oxidation of polyamines generates a large amount of the ROS, hydrogen peroxide. Peroxide causes oxidative stress, a condition in which cells produce an excess of oxygen-free radicals, which are known to play a key role in cell signalling and prostate cancer development.

"These results demonstrate that polyamine oxidation is one of the major causes of androgen-induced oxidative stress in prostate cancer cells," said Dr Basu. "The dis
'"/>

Source:European Organisation for Research and Treatment of Cancer


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists discover way block growth prostate cancer cells

(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
(Date:6/24/2015)... 24, 2015 The biologics safety testing market ... for the market include growth of the pharmaceutical and ... launches. Over the years, the number of drug approvals ... 2010, the FDA approved 225 drug applications and Health ... Europe accounted for 3,822 of the ...
(Date:6/23/2015)... Minn. , June 23, 2015   ... company that supports the entire spectrum of clinical ... iMedNet ™ , the company,s intuitive, ... been awarded a Silver 2015 Stevie® Award by ... Health Products & Services Website category.  The American ...
Breaking Biology News(10 mins):Latin America Biomedical Sensors Market Report 2015-2020 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2
... there is growing interest in maintaining the Earth's natural mechanisms ... week in the on-line edition of the journal Science suggests ... in determining how much carbon these natural storehouses are able ... crucial ecosystem services such as preventing erosion. , The ...
... a recent study published in the Journal of Biological Chemistry, ... is essential for degradation of the biopolymer chitin. This new ... and could also lead to the discovery of similar molecules ... research appears as the "Paper of the Week" in the ...
... that research done with zebrafish may be able to play ... cancer and the mutations that can lead to it - ... essential to preventing tumors. , The findings were published in ... by researchers from Oregon State University and two Boston hospitals, ...
Cached Biology News:Seeing the forest and the trees 2New molecule may aid in production of biofuels and fungi-resistant plants 2Zebrafish may hold key to improved cancer research 2Zebrafish may hold key to improved cancer research 3
(Date:7/3/2015)... ... ... The global failure analysis market is expected to reach $7,147.0 million by 2020, at ... grow at the highest CAGR of 8.46%; its growth is expected to be driven ... institutions for root cause analysis of failure. The market based on the geographic regions ...
(Date:7/2/2015)... Brooklyn, NY (PRWEB) , ... July 03, 2015 , ... Cuvettes have been used in ... book style catalog to find the cuvette they needed. As expected, this was a ... would order the wrong part because they were not able to navigate the complex catalog ...
(Date:7/2/2015)... Memphis, TN (PRWEB) , ... July 02, 2015 ... ... in the development and manufacturing of surgical instruments in Orthopedics, announced today the ... orthopedic contract-manufacturing and the world's largest provider of surgical instruments to the Spine ...
(Date:7/1/2015)... and BANGALORE, India , July 1, ... company that uses next generation sequencing technology to empower ... A. Storrer as chief executive officer. In his ... be responsible for all strategy, business expansion and worldwide ... has served as Strand,s chairman and CEO since its ...
Breaking Biology Technology:Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5New Cuvette E-Commerce Website Launched by FireflySci 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3
... indexed listing includes over 4,000 antibody products with documented ... ... 27 Sigma-Aldrich(TM) (Nasdaq:,SIAL) is pleased to announce the new ... science., (Photo: http://www.newscom.com/cgi-bin/prnh/20071127/AQTU011 ), The 320-page Sigma ...
... Inc. (TSX:,ONC, NASDAQ: ONCY) ("Oncolytics") today announced that ... for the Treatment of Neoplasia.",The claims describe methods ... inactivated PKR, whether the PKR is inactivated by ... a host cellular protein responsible for preventing,virus replication ...
... NanoSystems Institute, the David Geffen School of Medicine at ... the structure of the largest cellular particle ever crystallized, ... , The research study, which focuses ... drug-therapy vehicle, appears in the Nov. 27 edition of ...
Cached Biology Technology:Sigma-Aldrich Announces Launch of a New Antibodies Catalog 2Sigma-Aldrich Announces Launch of a New Antibodies Catalog 3Oncolytics Biotech Inc. Announces Issuance of 24th U.S. Patent 2Researchers outline structure of largest nonvirus particle ever crystallized 2
... kit for 25 chips provides the chips ... analysis (at nanogram levels) with the Experion ... RNA StdSens microfluidic chips, 2 x 1,250 ... RNA StdSens stain, 2 x 20 microliters ...
...
... is a full featured, two laser, six detector ... Cytometer, CFlow Software, and a PC for operation ... all the capabilities of the best selling flow ... C6 Flow Cytometer System has six detectors to ...
Fingerprinting II Basic software is used for analyzing fingerprint sample types (electrophoretic gels, HPLC and other chromatographic patterns, spectrophotometric and densitometric curves)....
Biology Products: