Navigation Links
Scientists discover way to block growth of prostate cancer cells

Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.

They found that a drug that blocks this pathway significantly prolonged survival and inhibited tumour development in mice that were genetically engineered to spontaneously develop prostate cancer and die of the disease. The hope is that this drug could be used eventually to treat men at high risk of developing prostate cancer and to prevent recurrences in men already treated for primary tumours.

Dr Hirak Basu told a news briefing at the EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Prague today (Wednesday 8 November): "Previous work has demonstrated that androgen treatment increased reactive oxygen species levels in androgen-dependent prostate cancer cells, but, until now, the pathway involved was unknown."

Dr Basu is an associate scientist and principal investigator in the Prostate Cancer Group at the Paul P. Carbone Comprehensive Cancer Center, Madison, WI, USA. He and his collaborators at the centre found that levels of a key enzyme, spermidine/spermine acetyl transferase (SSAT), which starts oxidation of polyamines, rose markedly when prostate cancer cells were treated with androgen. Polyamines are small molecules produced in large quantity by the prostate gland and are secreted in the seminal fluid. Oxidation of polyamines generates a large amount of the ROS, hydrogen peroxide. Peroxide causes oxidative stress, a condition in which cells produce an excess of oxygen-free radicals, which are known to play a key role in cell signalling and prostate cancer development.

"These results demonstrate that polyamine oxidation is one of the major causes of androgen-induced oxidative stress in prostate cancer cells," said Dr Basu. "The dis
'"/>

Source:European Organisation for Research and Treatment of Cancer


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists discover way block growth prostate cancer cells

(Date:4/27/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® Smart ... week of May, 2015 and will be fulfilling all ... Gino Pereira , Chief Executive Officer said, ... Wocket® enters the consumer market. We would like to ...
(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... scientist from the University of Salamanca and another from Yale ... behaviour of Acanthodactylus beershebensis , a lizard species from ... study, these reptiles move less and catch less mobile and ... Many theoretical models had predicted this result, but until now ...
... OptiNose is pleased to announce the publication of results ... and tolerability of its novel, intranasal drug/device product for ... in Rhinology , the official journal of the ... with nasal polyps is a chronic disease that can ...
... been awarded a U.S. Air Force Center of Excellence ... and to develop tools to optimize critical cognitive processes ... Center, known as the Bio-nano-enabled Inorganic/Organic Nanostructures and Improved ... and Kenneth Sandhage, professors in Georgia Tech,s School of ...
Cached Biology News:Lizards change their diet to avoid predators 2New data on highly effective treatment for chronic rhinosinusitis with nasal polyps 2Air Force Center of Excellence awarded in nanostructures and improved cognition 2Air Force Center of Excellence awarded in nanostructures and improved cognition 3Air Force Center of Excellence awarded in nanostructures and improved cognition 4
(Date:5/27/2015)... Md. , May 27, 2015  Northwest Biotherapeutics, ... company developing DCVax® personalized immune therapies for cancer, announced ... Technical Officer of the Company, will be making an ... Meeting in Chicago on Saturday, ... at the Industry Expert Theater in McCormick Place. ...
(Date:5/27/2015)...  US-Australian drug discovery and development company, Novogen Limited (ASX: ... present at the Brain Tumor Biotech Summit 2015, being held ... 2015. The venue is the Lennox Hill Hospital, East 76 ... The Brain Tumor Biotech Summit brings together the nation,s ... investment community to promote innovative new therapies for brain tumors.  ...
(Date:5/27/2015)... , May 27, 2015 ­ Caris Life ... promise of precision medicine, today announced it has appointed ... a center of excellence site in the Caris Centers ... Levine Cancer Institute is one of the largest ... than 11,000 new cancer patients annually. Derek Raghavan ...
(Date:5/26/2015)... WORMS, GERMANY – May 26, 2015 ... announces that its manufacturing facility in Worms, Germany ... EXCiPACTâ„¢, an independent organization that certifies manufacturers, suppliers, ... All three Grace facilities that produce its SYLOID® ... have now received GMP certification, following the Curtis ...
Breaking Biology Technology:NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 2NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 3Novogen to Present at Brain Tumor Biotech Summit 2015 2Novogen to Present at Brain Tumor Biotech Summit 2015 3Novogen to Present at Brain Tumor Biotech Summit 2015 4Novogen to Present at Brain Tumor Biotech Summit 2015 5Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 2Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 3Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 4CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2
... , , , , , , , , ... Biotech Ltd. ( SVA),a leading provider of biopharmaceutical products in ... presented with the Annual,Innovation Award by China Central Television (CCTV). ... nominees for the CCTV,s China,s 2009 Economic,Man-of-the-Year. Results were ...
... River green on St. Patrick,s Day. It,s been used to ... at Northwestern University have used it to examine the thinnest ... dye fluorescein, and Jiaxing Huang, assistant professor of materials science ... Science, and his research group have used the dye to ...
... ... clinical consulting services, competitive intelligence and strategic planning for the medical device and biotechnology ... company in the development, promotion and implementation of The RC Insight Group. , ... (PRWEB) December 23, 2009 ...
Cached Biology Technology:Sinovac's CEO Weidong Yin Presented with Annual Innovation Award by China Central Television 2Sinovac's CEO Weidong Yin Presented with Annual Innovation Award by China Central Television 3An easy way to see the world's thinnest material 2Lori Kahler Appointed President of The RC Insight Group 2
... The MAX POWER 500V Programmable Power ... instruments which can handle virtually any ... high current blotting. It is unique ... displays. The MAX POWER Programmable Power ...
Coating : Poly-D-Lysine ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vol working : 2.5-3.0 ml ...
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
Biology Products: