Navigation Links
Scientists discover way to block growth of prostate cancer cells

Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.

They found that a drug that blocks this pathway significantly prolonged survival and inhibited tumour development in mice that were genetically engineered to spontaneously develop prostate cancer and die of the disease. The hope is that this drug could be used eventually to treat men at high risk of developing prostate cancer and to prevent recurrences in men already treated for primary tumours.

Dr Hirak Basu told a news briefing at the EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Prague today (Wednesday 8 November): "Previous work has demonstrated that androgen treatment increased reactive oxygen species levels in androgen-dependent prostate cancer cells, but, until now, the pathway involved was unknown."

Dr Basu is an associate scientist and principal investigator in the Prostate Cancer Group at the Paul P. Carbone Comprehensive Cancer Center, Madison, WI, USA. He and his collaborators at the centre found that levels of a key enzyme, spermidine/spermine acetyl transferase (SSAT), which starts oxidation of polyamines, rose markedly when prostate cancer cells were treated with androgen. Polyamines are small molecules produced in large quantity by the prostate gland and are secreted in the seminal fluid. Oxidation of polyamines generates a large amount of the ROS, hydrogen peroxide. Peroxide causes oxidative stress, a condition in which cells produce an excess of oxygen-free radicals, which are known to play a key role in cell signalling and prostate cancer development.

"These results demonstrate that polyamine oxidation is one of the major causes of androgen-induced oxidative stress in prostate cancer cells," said Dr Basu. "The dis
'"/>

Source:European Organisation for Research and Treatment of Cancer


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists discover way block growth prostate cancer cells

(Date:9/12/2014)... and POINT ROBERTS, Washington , ... Investorideas.com ( http://www.investorideas.com ) a global news source covering leading ... and experts on the September 9 th launch of ... of Goode Intelligence, Janice Kephart , founder of the ... Pereira of NXT-ID, Inc, (NASDAQ: NXTD ) ...
(Date:9/11/2014)... Ill. Chicago residents today might have had a ... of Illinois had been approved. It was a straight ... just south of the Rock and Mississippi River confluence. ... had the proposed northern border not been changed, the ... and footprint with the northern 51 miles of the ...
(Date:9/11/2014)... Two Northeastern University researchers and their international colleagues ... the role of neutral evolution in the biogeographic ... published Thursday in the journal Science . ... in a neutral agent-based model"was co-authored by Ferdi ... professor of civil and environmental engineering; his doctoral ...
Breaking Biology News(10 mins):Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 2Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 3Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 4Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 5Original northern border of Illinois was south of Chicago and Lake Michigan 2Original northern border of Illinois was south of Chicago and Lake Michigan 3Microbes evolve faster than ocean can disperse them 2
... I. Gordon, MD, at Washington University School of Medicine in ... find new ways to diagnose, treat and prevent a critical ... is funded by an $8.3 million grant from the Bill ... link between obesity and the trillions of friendly microbes that ...
... nowadays. It is quite unexceptional for a sports jacket, ... the case of working clothes, the functionality is mostly ... and so on, with wearer comfort (mostly) not being ... their name suggests, hold off bullets but they are ...
... the Salk Institute for Biological Studies and Iowa State ... a role in the production of seed oils, substances ... biofuels. Scoring a rare scientific hat trick, the ... plants ( Arabidopsis thaliana ) that regulate the metabolism ...
Cached Biology News:Washington University receives $8 million to lead international childhood malnutrition effort 2Washington University receives $8 million to lead international childhood malnutrition effort 3Washington University receives $8 million to lead international childhood malnutrition effort 4Real smart: Protective clothing with built-in A/C 2Discovery of plant proteins may boost agricultural yields and biofuel production 2Discovery of plant proteins may boost agricultural yields and biofuel production 3
(Date:9/13/2014)... Phoenixville, PA (PRWEB) September 13, 2014 ... medical device innovations, is proud to announce the successful ... Health Network bariatric surgeons Leonardo Claros, MD, FACS, FAMBS, ... ViSiGi 3Dâ„¢ Sleeve Gastrectomy Calibration System. , This ... a postgraduate course of more than four hundred surgeons ...
(Date:9/12/2014)... , Sept. 12, 2014 Research ... "Global Dry Film Photoresist Industry Report 2014" ... Dry Film Photoresist Industry Report 2014 is a professional ... global dry film photoresist industry . The ... definitions, classifications, applications and industry chain structure. The dry ...
(Date:9/11/2014)... RURO, Inc., a leading laboratory ... and sample management solutions provider, announces the release ... on the most recent version of its Limfinity® ... seen mass adoption, especially from multi-license environment customers. ... brought an entirely new User Interface and version ...
(Date:9/11/2014)... sheet of carbon, can be randomly decorated with oxygen ... could have a significant impact on the chemical, pharmaceutical ... an ultra-strong, non-corrosive coating for a wide range of ... used to paint various surfaces ranging from glass to ... treatment, the resulting coatings behave like graphite in terms ...
Breaking Biology Technology:Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Global Dry Film Photoresist Industry Report 2014 2Limfinity® Version 5.1 Available 2Graphene paints a corrosion-free future 2
... one of the best possible technologies for providing ... to power our civilization. However, for this dream to ... inexpensive elements using low-cost, less energy-intensive processing chemistry, and ... electricity. A team of researchers with the U.S. Department ...
... SynCardia Systems, Inc. ( www.syncardia.com ), manufacturer of the SynCardia ... company pages on Facebook , Twitter and ... about the world,s only FDA, Health Canada and CE (Europe) ... implants of the Total Artificial Heart, accounting for more than ...
... 31, 2011 BioMed Realty Trust, Inc. (the "Company") ... of the 4.50% Exchangeable Senior Notes due 2026 (CUSIP ... Realty, L.P. (the "Operating Partnership"), which are fully and ... surrender their Notes for purchase by the Operating Partnership ...
Cached Biology Technology:Down to the wire 2Down to the wire 3Down to the wire 4SynCardia Goes Social on Facebook, Twitter and LinkedIn 2SynCardia Goes Social on Facebook, Twitter and LinkedIn 3SynCardia Goes Social on Facebook, Twitter and LinkedIn 4BioMed Realty Announces Repurchase at Option of Holders and Redemption of 4.50% Exchangeable Senior Notes Due 2026 2BioMed Realty Announces Repurchase at Option of Holders and Redemption of 4.50% Exchangeable Senior Notes Due 2026 3BioMed Realty Announces Repurchase at Option of Holders and Redemption of 4.50% Exchangeable Senior Notes Due 2026 4BioMed Realty Announces Repurchase at Option of Holders and Redemption of 4.50% Exchangeable Senior Notes Due 2026 5