Navigation Links
Scientists create digital bacteria to forge advances in biomedical research

Scientists at the University of Chicago and Argonne National Laboratory have constructed a computer simulation that allows them to study the relationship between biochemical fluctuations within a single cell and the cell's behavior as it interacts with other cells and its environment.

The simulation, called AgentCell, has possible applications in cancer research, drug development and combating bioterrorism. Other simulations of biological systems are limited to the molecular level, the single-cell level or the level of bacterial populations. AgentCell can simultaneously simulate activity on all three scales, something its creators believe no other software can do.

"With AgentCell we can simulate the behavior of entire populations of cells as they sense their environment, respond to stimuli and move in a three-dimensional world," said Thierry Emonet, a Research Scientist in Philippe Cluzel's laboratory at the University of Chicago's Institute for Biophysical Dynamics.

Emonet and his colleagues have verified the accuracy of AgentCell in biological experiments. AgentCell now enables scientists rapidly to run test experiments on the computer, saving them valuable time in the laboratory later.

Emonet is the lead author of a paper announcing the development of AgentCell that was published in the June 1 issue of the semimonthly journal Bioinformatics. His co-authors are Argonne's Charles Macal and Michael North, and the University of Chicago's Charles Wickersham and Philippe Cluzel. The work was funded by the U.S. Department of Energy and the University of Chicago/Argonne National Laboratory Seed Grant Program.

AgentCell will be used to tackle a major goal in single-cell biology today: to document the connection between internal biochemical fluctuations and cellular behavior. "The belief is that these fluctuations are going to be reflected in the behavior of the cell as shown experimentally by John Spudich and Daniel Koshland in 1976,
'"/>

Source:University of Chicago


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:9/18/2014)... Washington State University researchers have developed a unique method ... waste cleanup in rural areas. , The first ... inexpensive and quick way to clean up waste from ... reducing pollution. , Professor Haluk Beyenal and graduate ... and Architecture discuss the system in the online edition ...
(Date:9/18/2014)... Colo., USA A new GSA Bulletin ... the lower Rio Puerco and Chaco Wash in northern ... rings from salt cedar and willow, investigators were able ... or greater. They then combined this data with aerial ... the history of these arroyos. , Arroyos are deep, ...
(Date:9/18/2014)... BUFFALO, N.Y. A sleep-promoting circuit located deep in ... deep sleep. Discovered by researchers at Harvard School of ... and Biomedical Sciences, this is only the second "sleep ... to be both necessary and sufficient to produce deep ... Neuroscience , the study demonstrates that fully half of ...
Breaking Biology News(10 mins):Researchers develop unique waste cleanup for rural areas 2Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7No sedative necessary: Scientists discover new 'sleep node' in the brain 2
... the Smithsonian Institution (US), Saint Louis University ... the discovery of an exciting new species from the daisy family. ... Andes were crowned by the discovery of the beautiful and extraordinary, ... the open access journal Phytokeys . The ...
... University of Iowa have created a bio patch to ... a nano-sized particle that delivers bone-producing instructions directly into ... platform seeded with particles containing the genes needed for ... regrew bone fully enough to cover skull wounds in ...
... legislation "have eviscerated" the ability to protect habitat ... at the University of Calgary and Dalhousie University ... were "politically motivated," unsupported by scientific advice ... with ecosystem-based management, fisheries biologists John Post and ...
Cached Biology News:Crown of Venezuelan paramos: A new species from the daisy family, Coespeletia palustris 2A bio patch that can regrow bone 2A bio patch that can regrow bone 3Changes to fisheries legislation have removed habitat protection for most fish species in Canada 2
(Date:9/18/2014)... , Sept. 18, 2014   Sigma-Aldrich ... today it has entered into a new gene ... Medical School,s Vector Core. Under the partnership, Sigma-Aldrich ... technology, experimental design consultation, and dedicated gene editing ... accelerate gene editing-based research at the U-M Medical ...
(Date:9/18/2014)... Artificial sweeteners, promoted as aids to weight loss and ... intolerance and metabolic disease; and they do it in ... of the gut microbiota the substantial population of ... of experiments in mice and humans, were published today ... Eran Elinav of the Weizmann Institute,s Immunology Department, who ...
(Date:9/18/2014)... 2014 Pipette.com announces brand new ... Capp, and AccuPet brand of pipettes. Micropipettes are ... or less and are a great tool for ... , The micropipette promotions were designed to offer ... products to help customers find the right solution. ...
(Date:9/17/2014)... -- The global consumption of squalene / squalane is expected ... skin-identical chemical that finds applications in various end user industries ... in other applications like high grade lubrication, and fiber coating ... players and is regionally segregated. Sophim ( France ... ( Japan ), SeaDragon Marine Oils Ltd. ( ...
Breaking Biology Technology:Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 2Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 3Squalene Market by Source (Animal & Vegetable) & by End-user Industry (Cosmetics, Pharmaceuticals & Food Industry) - Global Trends & Forecasts to 2019 2Squalene Market by Source (Animal & Vegetable) & by End-user Industry (Cosmetics, Pharmaceuticals & Food Industry) - Global Trends & Forecasts to 2019 3
... 2012  The Angel Investor Management (AIM) Group announced today the ... the capital needs of entrepreneurs and investors in a seven-county ... bringing together a single network of angel investor groups in ... the economies of scale will work to benefit all," said ...
... 2012  Accelerate Brain Cancer Cure (ABC2) and ... medical centers to accelerate clinical validation of Exosome,s ... in brain cancer.  The collaboration ... biofluid-based diagnostic technology for early identification, progression ...
... CENTERVILLE, Mass., Feb. 6, 2012 UV Flu Technologies, Inc. ... to announce it is ahead of schedule in its continuing program ... Asher Enterprises, LLC, that the remaining and final convertible note, in ... "The progress we have made in the last twelve ...
Cached Biology Technology:Statewide Network of Angel Investor Groups Announced in Alabama 2Accelerate Brain Cancer Cure and Exosome Diagnostics Collaborate to Advance Clinical Studies of Exosome Biofluid Molecular Diagnostics Technology in Brain Cancer 2Accelerate Brain Cancer Cure and Exosome Diagnostics Collaborate to Advance Clinical Studies of Exosome Biofluid Molecular Diagnostics Technology in Brain Cancer 3Accelerate Brain Cancer Cure and Exosome Diagnostics Collaborate to Advance Clinical Studies of Exosome Biofluid Molecular Diagnostics Technology in Brain Cancer 4UV Flu Technologies Continues Aggressive Program to Pay off Convertible Debt 2UV Flu Technologies Continues Aggressive Program to Pay off Convertible Debt 3
...
...
...
... Clone/PAD: ZMD.366. Immunogen: ... internal region of human SENP1. ... human ~73 kDa SENP1. ... or DYKDDDDK)-HA-tagged-SENP1 transfected Hep2 cell ...
Biology Products: