Navigation Links
Researchers report breakthrough against world’s deadliest viruses

Scientists from the Public Health Agency of Canada - with assistance from the U.S. Army Medical Research Institute of Infectious Diseases - have developed vaccines against the Ebola and Marburg viruses that have been shown to be effective in non-human primates.

In a study published in this month's Nature Medicine, Canadian researchers Dr. Heinz Feldmann and Dr. Steven Jones of PHAC's National Microbiology Laboratory and Dr. Thomas Geisbert of USAMRIID report that the vaccines have proven 100 percent effective in protecting monkeys against infection from these often deadly viruses.

Monkeys are known to develop hemorrhagic fever symptoms that are similar to those observed in humans infected by these viruses. Demonstrating that these vaccines are safe and effective in monkeys is a promising indicator of their real potential for use in humans.

"When you see the tragedies these viruses cause, it's very frustrating that we can't do more to help people," said Dr. Feldmann, who (along with Dr. Jones and others from PHAC) has been providing on-site rapid diagnostic support to the current Marburg outbreak in Angola. "It'll be some time before we can use these vaccines in the field, but it's satisfying to know that we're getting closer."

According to Dr. Geisbert, this is the first vaccine system, or platform, that has protected nonhuman primates from both Ebola and Marburg. "In addition, the vaccine targets dendritic cells, which are the same cells that Ebola and Marburg attack," said Dr. Geisbert. "These cells are also important in generating a protective immune response. So the vaccine goes exactly where we want it to go."

The study describes how Canadian researchers developed the vaccines by replacing a surface protein in an animal pathogen, called vesicular stomatitis virus, with a surface protein from either the Ebola or Marburg viruses. Following extensive work, including trials with mice and guinea pigs, the PHAC researchers colla
'"/>

Source:US Army Medical Research Institute of Infectious Diseases


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:9/17/2014)... Mich. Mutations in the human retinoblastoma protein gene ... State University scientists have turned to fruit fly eyes ... , In a paper featured on the cover ... Biological Chemistry , Michigan State University researchers provide the ... to those present in the human cancer gene, said ...
(Date:9/17/2014)... significantly faster since the 1960s. The typical development phases ... have accelerated -- by as much as 70 percent. ... by scientists from Technische Universitt Mnchen based on long-term ... observed since 1870. Their findings were published recently in ... dieback" was a hot topic, with the very survival ...
(Date:9/16/2014)... Center for Children,s Environmental Health at the Mailman School ... association between childhood asthma and prenatal exposure to two ... Results appear online in the journal Environmental Health ... during pregnancy to higher levels of the chemicals, butylbenzyl ... percent and 78 percent increase in risk of developing ...
Breaking Biology News(10 mins):Abnormal properties of cancer protein revealed in fly eyes 2Global change: Trees continue to grow at a faster rate 2Global change: Trees continue to grow at a faster rate 3Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3
... began contributing to environmental lead pollution as early as ... research report. The Pitt research team detected ... world in the northernmost region of Michigan, suggesting metal ... earlier in North America than in Europe, Asia, and ...
... Renewable Energy Laboratory (NREL) is partnering with Cobalt Technologies, ... that jet fuel can be made economically and in ... switch grass. "This can be an important step ... using biomass resources," NREL Manager for Bioprocess Integration R&D ...
... NY) Today, researchers at Albert Einstein College ... conference on Jewish genetics designed to encourage collaboration and ... scientists identify causes and potential treatments for population-specific diseases ... population. The genetic makeup of Ashkenazi Jews ...
Cached Biology News:Oldest record of human-caused lead pollution detected 2NREL teams with Navy, private industry to make jet fuel from switchgrass 2Albert Einstein College of Medicine hosts conference on Jewish genetic research 2
(Date:9/17/2014)... -- BioClinica®, Inc., a leading provider of outsourced clinical ... its experts are speaking at the 20th Annual ... held September 28 to October 1 in ... the innovative Compass technology, a risk-based monitoring ... earlier this year, is up for the Technology ...
(Date:9/17/2014)... PITTSBURGH , Sept. 17, 2014 ... maker of MD-Cu 29 antimicrobial copper, announces Gilmour ... points to the first EPA-registered antimicrobial solid touch surface ... copper is a reasonably priced surface that kills greater ... 2 hours of exposure. 1 ...
(Date:9/17/2014)... MARLBOROUGH, Mass. , Sept. 17, 2014 /PRNewswire/ ... ), a biotechnology company focused on discovering, developing ... needs using RNA-targeted technologies, today announced that it has ... Patent and Trademark Office on its unique delivery ... ® ) to phagocytic cells for the treatment ...
(Date:9/17/2014)... 2014 First antibacterial ... a truly novel class of anti-infective in ... a biopharmaceutical company developing a truly novel ... has secured £4.0m ($6.4m) to advance the ... a range of Gram-positive infections including  Clostridium ...
Breaking Biology Technology:BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 2RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 2MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 3MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 6MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 7
... that the first quarter has come and gone and daylight savings ... snow. The stock market, on the other hand, is in the ... not pretty almost uniformly across the board. Only the Dow Jones ... may be where the song Stormy Monday came from). The Nasdaq ...
... business online has been a struggle for businesses ... by online transactions and corporate branding. , ,Local ... outfunded, outstaffed and outmarketed online by larger competitors. ... and consultants struggle to adapt "personal touch" driven ...
... a maker of automotive and ... bought Pro-Tel Inc. for an ... a contracting company founded in ... 70 employees. Its repair and ...
Cached Biology Technology:Midwest shares in stock-market bloodshed as biotechs falter 2Succeeding online without a Web site 2Succeeding online without a Web site 3Succeeding online without a Web site 4
... is a member of a nuclear ... that heterodimerize with retinoic acid-like receptor ... regulation of glucose and lipid metabolism. ... anti-diabetic agents called thiazolidinediones (TZD) or ...
... Preparation Reconstitution: one vial contains ... ficoll and 50 mg PVP; ... water yields a 50concentrate Special ... 1.00 g/mL (20 C) Quality ...
... Antibody Capture Kit eliminates ... optimization steps typically required ... This kit enables the ... multiple antigens based on ...
... This CLS number is a new ... Cornings product number. If showing no ... old Sigma-Aldrich number (R4276) or contact ... cap polystyrene (expanded surface, easy grip) ...
Biology Products: