Navigation Links
Researchers identify target for cancer drugs

For nearly a decade, scientists have been trying to fully understand a particular communication pathway inside of cells that contributes to many malignant brain and prostate cancers. While scientists have identified elements of this pathway, other key components have remained a mystery. Researchers at Whitehead Institute now have discovered a missing puzzle piece, a finding that may present drug makers with a significant new cancer target.

"We believe that we have identified a component that researchers have been looking for since 1996," says Whitehead Associate Member David Sabatini, who is also an Assistant Professor of Biology at MIT.

At the heart of this new research is a protein called Akt, an important player in the regulation of cell division and survival. Abnormally high activation of Akt has long been implicated in a variety of cancers. If Akt travels to the cell membrane, it is switched on and promotes cell division, often contributing to tumor growth as a result. However, as long as it stays within the cell cytoplasm, it remains relatively inactive. That's because the tumor-suppressor protein PTEN keeps Akt in check by destroying lipids in the cell membrane that normally draw Akt to the surface. In a sense, PTEN keeps a leash on Akt and thus suppresses cell division.

But when PTEN is mutated and unable to function, Akt breaks free. It makes its way to the cell membrane where other proteins activate it, thereby enabling Akt to contribute to tumor growth. "When a cell loses PTEN through, say, a mutation, Akt goes gangbusters," says Sabatini.

The exact means by which Akt switches on when it reaches the cell membrane has only been partially understood. As a result, researchers have lacked a clear idea about how to prevent the process. However, in the February 18 issue of the journal Science, researchers from the Sabatini lab report on discovering an important missing piece of the activation process.

This missing componen
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers discover molecule that causes secondary stroke
6. Researchers find missing genes of ancient organism
7. Researchers trace evolution to relatively simple genetic changes
8. Researchers add new tool to tumor-treatment arsenal
9. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Researchers develop rapid diagnostic tool for pathogen identification
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers identify target for cancer drugs

(Date:7/23/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ) has ... of the Biometrics Industry 2015 " report ... biometrics market is likely to witness significant growth ... the uptake of multiple technologies available. The year ... growth of biometrics in existing applications as well ...
(Date:7/21/2015)... 2015 Passwords have proven futile for ... recent U.S. Office of Personnel Management breach. Biometric ... conundrum, but developers and end-users are concerned about ... dilemma, Biometrics-as-a-Service provider HYPR Corp. announced today the ... third party integration. A video ...
(Date:7/13/2015)... , Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION ... new convenient and secure method to make payments.  ... payment methods, introduced with its groundbreaking voice-direct payment ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4
... just been seen by synchronizing brain waves in a working ... of Health suggests. The more in-sync such electrical signals of ... more those cells held the short-term memory of a just-seen ... a grantee of NIH,s National Institute of Mental Health (NIMH), ...
... USA In the evolutionary long run, small critters tend ... the idea attributed to paleontologist Edward Cope, now known as ... new test of this rule as it applies dinosaurs shows ... long time, dinosaurs were thought to be the example of ...
... in Norway have found new support for their theory ... non-psychotic individuals, leading to long-term psychosis. In an fMRI ... , researchers found a different brain activity pattern in ... patients without prior cannabis use. The results ...
Cached Biology News:In-sync brain waves hold memory of objects just seen 2Were dinosaurs destined to be big? Testing Cope's rule 2Cannabis use mimics cognitive weakness that can lead to schizophrenia 2
(Date:7/28/2015)... 28, 2015  PDL BioPharma, Inc. (PDL, or the ... Company will release its second quarter 2015 financial results ... August 5, 2015, after market close. PDL,s management will ... 4:30 p.m. Eastern Time to discuss the financial results. ... available via the webcast link on the PDL website. ...
(Date:7/28/2015)... , ... July 28, 2015 , ... ... than EUR 1.022 billion in 2013; while production volume reached close to 1.84 ... producing country with a share of 75.5% of the region’s total aluminium hydroxide ...
(Date:7/28/2015)... ... July 28, 2015 , ... VetStem Biopharma will be offering weekly private guided ... local area veterinarians. , The tour and course will be given every Wednesday at ... VetStem’s Poway facility. Staff members are welcome to attend with their veterinarian as well. ...
(Date:7/28/2015)... July 28, 2015  Kerastem Technologies announce that the ... U.S. FDA Center For Biologics Evaluation and Research (CBER) ... a clinical trial investigating the safety and feasibility of ... early male pattern baldness (androgenic alopecia). The ... initial clinical work in Europe ...
Breaking Biology Technology:PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 3VetStem Biopharma weekly veterinary continuing education classes and GMP manufacturing facility tour 2Kerastem Receives Conditional Approval from FDA for Alopecia Trial 2
... Technology Council , a policy advisor to the governor ... eight additions to its board of directors. , ,The ... board that includes more than three dozen members of ... organization leaders: , , Eric Apfelbach, president and CEO ...
... Sciences today announced the release of a product that ... proteins, and perhaps improve the cost effectiveness of drug discovery. ... an extension of the company's existing PreserveX line, and it ... Society of Japan in Kyoto, Japan. CEO Ralph Kauten said ...
... move forward on its deployment of Project Lightspeed? , ,If ... be setting its sights higher on real broadband and long-term ... marketing strategy of Project Lightspeed should be to get fiber ... a true broadband package. Instead, it is a way to ...
Cached Biology Technology:AT&T should set sights higher than repackaging DSL with Project Lightspeed 2AT&T should set sights higher than repackaging DSL with Project Lightspeed 3AT&T should set sights higher than repackaging DSL with Project Lightspeed 4AT&T should set sights higher than repackaging DSL with Project Lightspeed 5AT&T should set sights higher than repackaging DSL with Project Lightspeed 6
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
A formulation of our Biolase DNA Polymerase which contains a Red Loading Dye...
Homo sapiens similar to Cytosolic acyl coenzyme A thioester hydrolase Antigen: Peptide...
Cag-A (IgG) -Ab EIA Sample Size: 10 l...
Biology Products: