Navigation Links
Researchers discover molecule that causes secondary stroke

Scientists at the University of Cincinnati (UC) College of Medicine have discovered the cause of a deadly type of secondary stroke known as cerebral vasospasm.

A constriction of the blood vessels in the brain, cerebral vasospasm usually occurs three to 10 days following a massive brain bleed known as hemorrhagic stroke. Sixty percent of patients who survive the initial stroke develop vasospasm, and 40 percent of them die from it.

Vasospasm, says neurology department researcher Joseph Clark, PhD, results from a buildup of toxins caused by bleeding from the initial stroke. "Normally the cerebral spinal fluid that envelopes the brain carries off wastes and exchanges them for nutrients at what's called the blood-brain barrier," Dr. Clark says. "After a hemorrhagic stroke, however, toxins given off by the brain bleed contribute to the development of specific molecules that later causes the constricting vasospasm." A research team led by Dr. Clark has now identified the molecules that trigger vasospasm, a breakthrough, he says, that "raises hopes of developing not only new ways to treat the condition, but also a diagnostic test to determine which hemorrhagic stroke survivors are at greater risk."

Several spinal fluid components were suspected of causing the vasospasm, Dr. Clark explains. They included hemoglobin, bilirubin and peroxidized lipids, and a group of bilirubin oxidation products that the researchers called BOXes.

Building on Dr. Clark's earlier studies in rats, the team measured each of the suspect agents in 12 hemorrhagic stroke patients. Within 10 days, four of the group suffered a secondary cerebral vasospasm. The same patients were also found to have elevated levels of bilirubin and significantly higher levels of BOXes.

One of the 12 who had elevated bilirubin, but hardly any BOXes, did not experience a secondary stroke.

When bilirubin is elevated, says team member Gail Pyne-Geithman, PhD, it must be exposed to
'"/>

Source:University of Cincinnati


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers find missing genes of ancient organism
7. Researchers trace evolution to relatively simple genetic changes
8. Researchers add new tool to tumor-treatment arsenal
9. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Researchers develop rapid diagnostic tool for pathogen identification
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers discover molecule that causes secondary stroke

(Date:7/23/2014)... The U.S. Environmental Protection Agency (EPA) today ... the University of Massachusetts Amherst School of Public ... three-year, $700,000 Science to Achieve Results (STAR) grant ... by Native subsistence hunters in subarctic North America ... exposure and to provide culturally-relevant recommendations for mitigation. ...
(Date:7/23/2014)... fable about the crow and the pitcher, a thirsty bird ... to drink from it, he finds the water level out ... pitcher, the bird drops pebbles into it one at ... him to drink his fill. , Highlighting the value of ... more effective than brute force. It also characterizes crows as ...
(Date:7/23/2014)... Defense recently awarded the STEMPREP Project at Southern ... its goal of increasing the number of minorities ... middle school students for the two-summer classroom phase ... students with summer opportunities at research labs. , ... School of Education and Human Development, boasts an ...
Breaking Biology News(10 mins):Studying impacts of indoor air pollution on tribal communities 2Studying impacts of indoor air pollution on tribal communities 3Smarter than a first-grader? 2Smarter than a first-grader? 3Smarter than a first-grader? 4Department of Defense awards $2.6 million grant to SMU STEM program for minority students 2
... are common, but few studies of lung nodule identification ... Researchers from Kaiser Permanente Southern California identified 7,112 patients ... information within the electronic medical record. Their ... International Association for the Study of Lung Cancer,s (IASLC) ...
... Your genes determine much about you, but environment can ... with consequences that can last a lifetime. In a ... ), researchers have for the first time shown that the ... the chemical modifications to DNA we are born with, that ...
... some cases of the progressive fatal neurological disease amyotrophic ... disease. Shedding light on how ALS destroys the cells ... in this gene affect the structure and growth of ... cells responsible for controlling muscles. People with ALS experience ...
Cached Biology News:Differences between human twins at birth highlight importance of intrauterine environment 2New gene mutations linked to ALS and nerve cell growth dysfunction 2New gene mutations linked to ALS and nerve cell growth dysfunction 3
(Date:7/23/2014)... , July 23, 2014  Having the right people ... vital to accelerating business growth and achieving clinical and ... Association (AHA) Leadership Summit, July 20-22, 2014, in ... of hospital executives and healthcare experts discussing how partnerships ... Carrocino , President & Chief Executive Officer of Cape ...
(Date:7/23/2014)... StemGenex® , the leading resource for ... at improving the lives of patients dealing with degenerative ... disease. StemGenex believes that a commitment to the ... when providing care to patients with degenerative diseases. ... accessible to the millions of individuals currently living with ...
(Date:7/23/2014)... Iowa (PRWEB) July 23, 2014 DuPont ... the business as vice president of Agricultural Biotechnology (ABT), ... Biotechnology where he served most recently as president, chief ... biotechnology and business leadership in the seed and crop ... said Paul E. Schickler , president of DuPont ...
(Date:7/23/2014)... -- regulated information -- UCB today announced an important ... positive topline results from the latest Phase 3 ... to evaluate the efficacy and safety of ... compared to placebo, as adjunctive treatment in adult ... controlled despite treatment with one or two concomitant ...
Breaking Biology Technology:MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7
... N.C., Dec. 8, 2010 Pharmaceutical Institute, ... pharmaceutical and biotech industry and a subsidiary of Campbell ... Hospital Marketplace e-course series.  It ... and Institutional IT Systems ...
... 8, 2010 Reportlinker.com announces that a new ... Merck KGaA: PharmaVitae Profile ... IntroductionThis analysis examines the historical and forecast ... sector. The profile encompasses global company strategy, portfolio ...
... 8, 2010 Aquatic Energy LLC announced today that ... Zulandi, have joined its Board of Directors.  "Our new ... experience to our company," stated David Johnston, CEO of ... time, as the company moves from proof-of-concept demonstration facilities ...
Cached Biology Technology:Hospital Marketplace E-Course Suite Adds Insight on Quality and Information Systems 2Reportlinker Adds Merck KGaA: PharmaVitae Profile 2Senior Energy Executives Join Aquatic Energy Board 2Senior Energy Executives Join Aquatic Energy Board 3
... enterprise microarray informatics platform for microarray data storage, ... and use it forever without paying ongoing license ... Acuity has all the analysis tools you need ... quality control statistics and normalization, all the way ...
... industry standard microarray image analysis software because ... analysis tools, visualizations, automation capabilities, performance and ... with every GenePix scanner, and it also ... all types of arrays. A wide range ...
A univariate (peak height or area) quantitative multi-component analysis package....
... H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH 2 (Disulfide ... peptide and 1 ... I-labelled peptide, please see ... ([ 1 2 ...
Biology Products: