Navigation Links
Researchers discover molecular mechanism that desensitizes us to cold

Mount Sinai School of Medicine researchers have discovered how the membrane protein that allows us to sense cold works and how this protein becomes desensitized so that one no longer feels the cold. The study, published this week as an advance online publication by Nature Neuroscience, focused on a specific region of the cold receptor which is found in many other receptors, including ones involved in taste, vision and fertilization. Therefore, the findings may have important implications across a wide range of areas.

Diomedes Logothetis, PhD, Dean of the Mount Sinai Graduate School of Biological Sciences, post-doctoral fellow Tibor Rohacs and colleagues studied the receptor that is responsible for the sensation of cold. They found that a specific region of this receptor interacts with a signaling lipid in the cell membrane called PIP2. Cold or menthol stimulate this receptor and alter the electrical properties of the membrane, a process that leads to the sensation of cold. When the receptor is stimulated, calcium enters the cell and stimulates the breakdown of PIP2. When PIP2 is broken down, the receptor becomes inactive, thus ending the sensation or desensitizing the cell to the cold stimulus.

"This finding provides critical information to help us understand how we sense heat and cold and from that to expand our understanding of temperature regulation," said Dr. Logothetis. "Additionally, because the region of this receptor that interacts with PIP2 is found in many similar membrane proteins, we now have a new lead in investigating regulation of the many functions in which these proteins are involved."

Many signals, such as neurotransmitters and growth factors are known to catalyze the breakdown of PIP2. Now that researchers know how PIP2 interacts with this large class of membrane proteins, they can begin to look out how these signals work and what effects they are having in various areas of the body.


'"/>

Source:Mount Sinai Hospital / Mount Sinai School of Medicine


Page: 1

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:3/10/2015)... -- Continuing its 167-year history of offering the Best, the ... Eye Scanning Password Authenticator , a device that confirms ... or sensitive data. Employing the same biometric ... device has a small camera that scans and saves ... them into an encrypted ID that cannot be forged ...
(Date:3/4/2015)... DUBLIN , Mar. 04, 2015 Research ... announced the addition of the "Global Biometrics ... their offering. The market for biometric ... CAGR of around 14% till 2020 ... will be increasing security needs, government projects and ...
(Date:2/25/2015)... 2015  ABC Financial Services (ABC), the leading ... and Fitness Industry, today announced enhancements to their ... latest upgrade includes advances to the agreement section ... via Identity One fingerprint biometrics. The features will ... displays at the International Health, Racquet & Sportsclub ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
... a component of salt, are elevated in many urban streams ... government study. Chloride levels above the recommended federal criteria ... 40 percent of urban streams tested. The study was ... chloride can inhibit plant growth, impair reproduction, and reduce the ...
... 16th 2009 / b3c newswire / - NiKem Research ... the Italian Ministry of Health, GLP certification of its bioanalysis ... NiKem Research has provided for many years high quality cost-effective ... ADME(T) and in vivo PK services associated to ...
... including the University of Colorado at Boulder have sequenced ... species, providing information that can be used to better ... Identifying such DNA barcodes can help wildlife officials ... species are in sharp decline from illegal trade estimated ...
Cached Biology News:Chloride found at levels that can harm aquatic life in urban streams of the Northern US 2NiKem Research receives certification for GLP Bioanalysis 2CU-Boulder team identifies DNA "barcodes to help track illegal trading of wildlife products 2CU-Boulder team identifies DNA "barcodes to help track illegal trading of wildlife products 3
(Date:3/27/2015)... 27, 2015 Working in collaboration with ... London , Richmond Pharmacology is the first ... 3 study for an investigational RNAi therapeutic being developed for ... the nerves and heart. Read press release ... Based at St Georges University of London ...
(Date:3/26/2015)... 26, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of ... the three months and full year ended December ... Results:Revenue for the quarter ended December 31, 2014 ... fourth quarter of 2013 and $1.5 million for ...
(Date:3/26/2015)... 2015  BioNano Genomics, Inc., the leader in genome ... as chief commercial officer. Salyer has more than 20 ... in life sciences. At BioNano, Salyer will oversee the ... platform to assemble a comprehensive view of complex genomes ... 32 institutions located in the United States ...
(Date:3/26/2015)... 2015 ReliantHeart, Inc., an innovative supplier ... supplier of precision transit-time flow measurement solutions, are collaborating ... the efficiency of the HeartAssist5® Left Ventricular ... experience greater mobility and peace of mind. , ... board, will draw 1/6th of the power required by ...
Breaking Biology Technology:Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
... has purchased a LEAP 3000 metrology system made by ... Wis. The Tohoku University system is the third system Imago has ... system in conjunction with its representatives based in Japan, the Noah ... enabling metrology at the atomic scale. , , ...
... - In Victorian England, the game of croquet was ... matter, and people could share the latest news without inhibition. ... goal of a research team working from the University ... to capture that sense of interactivity and bring it to ...
... you noticed recently the earnest discussions about a seemingly inalienable ... maybe that overstates the argument a little bit, but the ... their blogging activities on what Apple considered competitive secrets is ... in various media. , ,Then in the not-quite-yet-news bin one ...
Cached Biology Technology:The Croquet Project: An open source solution to the OS monopoly 2The Croquet Project: An open source solution to the OS monopoly 3The Croquet Project: An open source solution to the OS monopoly 4The Croquet Project: An open source solution to the OS monopoly 5Social engineering - Coming to an IT ship near you? 2Social engineering - Coming to an IT ship near you? 3
... MBP Coated Microplate, 96 Well Anti-phospho-MBP, ... Magnesium/ATP Cocktail, #20-11 Blocking Buffer, 10X, ... LumiGLO™ Chemiluminescen Applications: ... Routinely evalauted by non-radioactive ...
... ActivePro In Vitro Translation ... E.coli lysate, synthesizes higher ... well as proteins with ... competing kits. This results ...
One-step, microplate or cuvet, colorimetric, detection range 0.3 g/dL to 5 g/dL. Procedure: 5 min....
The Varian 4000 GC/MS system offers three easily switchable ionization configurations: internal ionization (II), external ionization (EI) or hybrid chemical ionization (CI)...
Biology Products: