Navigation Links
Researchers discover molecular mechanism that desensitizes us to cold

Mount Sinai School of Medicine researchers have discovered how the membrane protein that allows us to sense cold works and how this protein becomes desensitized so that one no longer feels the cold. The study, published this week as an advance online publication by Nature Neuroscience, focused on a specific region of the cold receptor which is found in many other receptors, including ones involved in taste, vision and fertilization. Therefore, the findings may have important implications across a wide range of areas.

Diomedes Logothetis, PhD, Dean of the Mount Sinai Graduate School of Biological Sciences, post-doctoral fellow Tibor Rohacs and colleagues studied the receptor that is responsible for the sensation of cold. They found that a specific region of this receptor interacts with a signaling lipid in the cell membrane called PIP2. Cold or menthol stimulate this receptor and alter the electrical properties of the membrane, a process that leads to the sensation of cold. When the receptor is stimulated, calcium enters the cell and stimulates the breakdown of PIP2. When PIP2 is broken down, the receptor becomes inactive, thus ending the sensation or desensitizing the cell to the cold stimulus.

"This finding provides critical information to help us understand how we sense heat and cold and from that to expand our understanding of temperature regulation," said Dr. Logothetis. "Additionally, because the region of this receptor that interacts with PIP2 is found in many similar membrane proteins, we now have a new lead in investigating regulation of the many functions in which these proteins are involved."

Many signals, such as neurotransmitters and growth factors are known to catalyze the breakdown of PIP2. Now that researchers know how PIP2 interacts with this large class of membrane proteins, they can begin to look out how these signals work and what effects they are having in various areas of the body.


'"/>

Source:Mount Sinai Hospital / Mount Sinai School of Medicine


Page: 1

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... Research and Markets has announced the addition ... Trends - Industry Forecast to 2025" report to their offering. ... The Global Biometric ... of around 15.1% over the next decade to reach approximately $1,580 ... market estimates and forecasts for all the given segments on global ...
(Date:3/22/2017)... YORK , March 21, 2017 ... Marketing Cloud used by retailers such as 1-800-Flowers ... its platform — Product Recommendations and Replenishment. Using Optimove,s ... give more personalized product and replenishment recommendations to ... but also on predictions of customer intent drawn ...
(Date:3/16/2017)... 2017 - Against identity fraud with DERMALOG solutions "Made in Germany "  ... ... project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial contribution against ... ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... 2017 , ... A recent survey conducted by the Weed Science Society of ... in 12 categories of broadleaf crops, fruits and vegetables, while common lambsquarters ranks as ... Canada participated in the 2016 survey, the second conducted by WSSA. A 2015 ...
(Date:5/23/2017)... MENLO PARK, CA (PRWEB) , ... May 23, 2017 , ... ... announced the publication of “Label-free isolation of prostate circulating tumor cells using Vortex ... publication is the result of a collaboration with Dr. Dino Di Carlo and Dr. ...
(Date:5/23/2017)... ... May 23, 2017 , ... Customers often prefer ... again and again. METTLER TOLEDO has released two new videos that show how ... integration of the ACT350 into Siemens and Allen Bradley PLCs is easy and ...
(Date:5/21/2017)... ... May 20, 2017 , ... CNSDose ... lengthy trial and error process by finding the right antidepressant faster. CNSDose ... the doctor-patient relationship through a personalized approach to treatment. , A ...
Breaking Biology Technology: