Navigation Links
Researchers Uncover Key Step In Manufacture of Memory Protein

A cellular enzyme appears to play a crucial role in the manufacture of a protein needed for long-term memory, according to a team of researchers led by scientists at the National Institute of Child Health and Human Development of the National Institutes of Health.

The protein is known as mBDNF, which stands for mature brain-derived neurotrophic factor. In an earlier study, another team of NICHD researchers had shown that mBDNF is essential for the formation of long-term memory, the ability to remember things for longer than a day.

“Understanding how BDNF is made may help us to better understand the learning process, perhaps leading to better treatments for disorders of learning and memory,?said Duane Alexander, M.D., Director of the National Institute of Child Health and Human Development.

The research team was led by Y.Peng Loh Ph.D, of NICHD’s Section on Cellular Neurobiology. The researchers published their work in the January 20 issue of Neuron.

Specifically, the researchers discovered that the enzyme carboxypeptidase E, (CPE) is needed to deliver the early, or inactive, form of BDNF ?proBDNF ?to a special compartment in the neuron (nerve cell.) Once in the compartment, proBDNF is chemically converted into active mBDNF. After mBDNF is formed, it is released to the outside of the neuron, where it binds to receptors on other neurons and stimulates them to form long-term memory.

Dr. Loh explained that, like other proteins, proBDNF is made inside the endoplasmic reticulum, a convoluted network of tubes and channels inside the cell. The proBDNF winds through the endoplasmic reticulum until it reaches another structure within the cell, the golgi apparatus. There, the proBDNF binds to CPE, which protrudes from special rafts of fatty, cholesterol-rich molecules known as lipids. If this binding process does not take place, proBDNF cannot be converted to its active form. Dr. Loh explained that the proBDNF molecule has four projection
'"/>

Source:NIH


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers reveal the infectious impact of salmon farms on wild salmon
4. Researchers identify target for cancer drugs
5. Researchers discover molecule that causes secondary stroke
6. Researchers find missing genes of ancient organism
7. Researchers trace evolution to relatively simple genetic changes
8. Researchers add new tool to tumor-treatment arsenal
9. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Researchers develop rapid diagnostic tool for pathogen identification
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Uncover Key Step Manufacture Memory Protein

(Date:5/6/2015)... Israel , May 6, 2015 LifeBEAM, ... most established helmet producer, announced today that they will ... Helmet, the world,s first bio-sensing cycling helmet and the ... released in two new colors in order to give ... the product. In addition, LifeBEAM and Lazer announced their ...
(Date:4/21/2015)... April 21, 2015 High ... policies are boosting access control systems market in ... to a recently published report by TechSci Research " ... the access control systems market in Saudi ... by 2020.The access control systems market in the Kingdom ...
(Date:4/14/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... New York Design Awards under the category  ,Product Design ... Design Awards are part of a global multi-disciplinary awards ... from the marketplace, industry and judging panel. Winners will ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... DCEvolution, climate change, stem cell researchScientists are frequently ... button issues that pervade the daily news headlines, ... bright lights of the television studio or leading ... from the American Institute of Biological Sciences (AIBS), ...
... College Park, MD, February 11, 2008 -- The American Institute ... Writing Awards today. The winners -- a scientist, a journalist, ... receive a prize of $3,000, an engraved Windsor chair, and ... pieces: , , Tim Folger won the 2007 AIP Science ...
... new thesis from he Swedish medical university Karolinska Institutet ... and women. The scientists who conducted the study think ... depression and chronic anxiety are more common in women ... neurotransmitter that is critical to the development and treatment ...
Cached Biology News:Priming scientists for successful media interviews 2Quantum weirdness, parallel worlds, dinosaur poop, and the ultimate fate of the universe... 2Quantum weirdness, parallel worlds, dinosaur poop, and the ultimate fate of the universe... 3Quantum weirdness, parallel worlds, dinosaur poop, and the ultimate fate of the universe... 4
(Date:5/27/2015)... , May 27, 2015 RXi ... company focused on discovering and developing innovative therapies ... today announced that it has commenced a public offering ... purchase shares of its common stock and overallotment ... stock. The shares of common stock, warrants and ...
(Date:5/27/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/8nqqdw/global_breast ) ... Breast Cancer Monoclonal Antibodies Market Outlook 2020" ... seems to dominate the breast cancer monoclonal antibody ... molecule, Herceptin has been able to dominate this ... breast cancer cells become recalcitrant and relapsed condition ...
(Date:5/27/2015)... Expanding in a big way into ... Biomed Inc. recently inked a deal with Arthur ... Ltd. , the largest endodontic distributor in Japan. The ... for Avalon Biomed, which manufactures Grey MTA Plus® and ... cements that have won renown from dentists around the ...
(Date:5/27/2015)... , May 27, 2015  Tikcro Technologies Ltd. (OTCQB: ... March 31, 2015. Aviv Boim ... continued pre-clinical work to generate functional specific antibodies, targeting ... stage, we are encouraged by the development progress. We ... new antibodies which modulate immune checkpoints gain clinical acceptance ...
Breaking Biology Technology:RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 2Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 3Dental Manufacturer Avalon Biomed Inks Major Deal with Japanese Distributor 2Dental Manufacturer Avalon Biomed Inks Major Deal with Japanese Distributor 3Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3
... EXTON, Pa., Oct. 27 BioTrends Research Group, ... results from 204 Nephrologists and 201 Renal Dietitians ... part of the management of dialysis,patients, particularly in ... Active Vitamin D, and Calcimimetic agents., In ...
... Research Group, Inc. was,named one of the 2007 ... by the Philadelphia 100(R), a joint project of ... of,Greater Philadelphia, and the Philadelphia Business Journal. The ... recognition is a testament to the uniqueness of ...
... call today at 4:30 p.m. ET -, SOUTH ... MGRM ) today reported financial results for the,quarter ... of $16.1 million for the third quarter of,2008, 55% ... 2007. This,growth was driven by revenue from Trofile(TM) for ...
Cached Biology Technology:BioTrends Releases TreatmentTrends(TM): Nephrology and Renal Dietitians, Two Syndicated Reports Providing Continuing Insight into the Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 2BioTrends Releases TreatmentTrends(TM): Nephrology and Renal Dietitians, Two Syndicated Reports Providing Continuing Insight into the Management of Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 3Monogram Announces 2008 Third Quarter Financial Results 2Monogram Announces 2008 Third Quarter Financial Results 3Monogram Announces 2008 Third Quarter Financial Results 4Monogram Announces 2008 Third Quarter Financial Results 5Monogram Announces 2008 Third Quarter Financial Results 6Monogram Announces 2008 Third Quarter Financial Results 7Monogram Announces 2008 Third Quarter Financial Results 8Monogram Announces 2008 Third Quarter Financial Results 9Monogram Announces 2008 Third Quarter Financial Results 10Monogram Announces 2008 Third Quarter Financial Results 11Monogram Announces 2008 Third Quarter Financial Results 12Monogram Announces 2008 Third Quarter Financial Results 13Monogram Announces 2008 Third Quarter Financial Results 14Monogram Announces 2008 Third Quarter Financial Results 15
...
...
Contains L-glutamine...
... 140kDa GenBank Accession NM_006256 ... acids 926-941 (DKKVKPPFIPTIRGRE) of human PRK2. ... Quality Assurance Routinely evaluated by immunoblot ... Stability 1 year at -20°C ...
Biology Products: