Navigation Links
Researchers Identify Cause of Early Bird Sleep Disorder

A few rare people who consistently nod off early, then wake up wide-eyed much before dawn, can blame a newly-found mutant gene for their sleep troubles, Howard Hughes Medical Institute researchers announced today.

This odd "time-shift" trait -- called familial advanced sleep phase syndrome (FASPS) -- was studied in one affected family by neurologist Louis J. Ptacek, a Howard Hughes Medical Institute researcher, and Ying-Hui Fu, at the University of California, San Francisco. Their report appears in the March 31, 2005, issue of the journal Nature.

The sleep-shifting mutation they found is in "a gene that was not previously shown in mammals to be a circadian rhythm gene," Ptacek explained. It's not yet clear how the mutant gene works to shift people's sleep time, their circadian rhythm, he added. But follow-on experiments in fruit flies and mice yielded results that are intriguing.

When the mutant gene was inserted into the flies, for example, it did the opposite of what was seen in the human family: it lengthened circadian rhythm. Yet in genetically engineered mice, the same gene change made the mice early risers -- mimicking what was seen in humans with FASPS.

So, studies of all three organisms -- flies, mice and humans -- "will help us understand the similarities and differences" in how the gene works in different settings, in different genetic backgrounds, he said. Experiments can be done in mice and flies, with results applying to humans, while the studies of humans can inform what's being seen in the flies and mice.

In addition, "these results show that the gene is a central component of the mammalian circadian clock, and suggest that mammalian and fly clocks may have different regulatory mechanisms, despite the highly conserved nature of their individual components," the research team wrote in Nature. Such studies may help unravel some of the fundamental mysteries of how circadian rhythms are established and maintained in
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Identify Cause Early Bird Sleep Disorder

(Date:10/2/2014)... CARTES SECURE CONNEXIONS 2014 Conference: A Step Ahead ... SECURE CONNEXIONS 2014 is being held at Paris Nord ... This 29 th  international meeting for the digital security ... together the global community of a constantly evolving sector. ... will set the pace for the event.   ...
(Date:10/1/2014)... discovered a new form of non-genetic inheritance, showing for ... previous sexual partner in flies at least., This ... Greek times, but was discredited in the early 20th ... out, UNSW Australia scientists Dr Angela Crean, Professor Russell ... male flies and studied their offspring., They found that ...
(Date:10/1/2014)... , Finnland, October 1, 2014 /PRNewswire/ ... Durchbruch im Bereich der Biowissenschaften   ... ein Kommen und Gehen zahlreicher Detektionstechnologien. Einige ... zum goldenen Standard. Die Photonen-Upconversion ist eine ... letzten Jahren mit Begeisterung aufgenommen wurde. Jetzt ...
Breaking Biology News(10 mins):CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 2CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 3CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 4Semen secrets: How a previous sexual partner can influence another male's offspring 2Innovative Verwendungslösung für die Photonen-Upconversion 2Innovative Verwendungslösung für die Photonen-Upconversion 3
... ease the antibiotic drought, scientists in Massachusetts are describing ... in efforts to discover badly needed new antibiotics. Their ... monthly journal. Frederick Ausubel and colleagues note ... germ-fighting drugs involve adding the potential drug to cultures ...
... Pa., Aug. 4 ComCam International, Inc. (Pink Sheets: CMCJ), ... and services, today announced that it has been selected by ... integration for a Maritime Domain Awareness and Seaport security project. ... stated, "Our two companies have worked informally for about a ...
... paint has been restricted in the United States since ... in major countries from three continents there is still ... to sell consumer paints that contain dangerous levels of ... PhD, and his team have found that approximately 73 ...
Cached Biology News:ComCam Selected by ePortation on New Maritime Domain Awareness Project 2Lead-based consumer paint remains a global public health threat 2Lead-based consumer paint remains a global public health threat 3
(Date:10/1/2014)... 2014  Spherix Incorporated (Nasdaq: SPEX) -- an intellectual property ... of intellectual property, announced today that the Markman ... in the U.S. District Court for the Northern ... been rescheduled for November 10, 2014.  This hearing ... Court Order setting the Markman date was received ...
(Date:10/1/2014)... Jolla, Calif. (PRWEB) September 30, 2014 ... announced the initial round of grants for the ... an undertaking that aims to develop and revolutionize ... circuit functions of the human brain. This first ... for fiscal year 2014 was allocated to more ...
(Date:10/1/2014)... Centreville, VA (PRWEB) October 01, 2014 ... the Diagnostic, Clinical Therapeutics, Healthcare IT, and Laboratory Testing ... and regulatory positions at the director level and above ... payers struggling to stay on top of rapid breakthroughs ... a result, many diagnostic companies have been forced to ...
(Date:10/1/2014)... Industry leaders from retail pharmacies to ... theme, ,Commercial Opportunities in the Era of Reform, from ... Elsevier , a world-leading provider of scientific, technical and ... of some of the industry,s most prominent healthcare leaders ... in the future. The Elsevier Healthcare and ...
Breaking Biology Technology:Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3
... Senesco Technologies , Inc. ("Senesco" or the "Company") (NYSE ... 2009, the Company entered into a definitive purchase agreement with Partlet ... 1,111,111 shares of its common stock (the "Shares") at a price ... up to 1,000,000 shares of common stock, which warrants are exercisable ...
... its discovery just a few years ago, graphene has ... super-materials poised to transform the electronics and nanotechnology landscape. ... of Arizona State University explains, this two dimensional honeycomb ... Its unusual properties make it ideal for applications that ...
... , KENILWORTH, N.J., July 9 Schering-Plough Corporation ... Schering-Plough K.K., the company,s country operation in Japan, ... mg Tablets for the treatment of major depressive ... Seika Kabushiki Kaisha, Ltd. Schering-Plough and Meiji Seika ...
Cached Biology Technology:Senesco Technologies Enters Into Agreement For Up To $1.0 Million In Financing 2Senesco Technologies Enters Into Agreement For Up To $1.0 Million In Financing 3Senesco Technologies Enters Into Agreement For Up To $1.0 Million In Financing 4Material world: Graphene's versatility promises new applications 2Material world: Graphene's versatility promises new applications 3Material world: Graphene's versatility promises new applications 4REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 2REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 3REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 4REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 5
... of Class II Biological Safety Cabinets ... to the world's highest safety standards. ... cabinets cannot be adjusted out of ... noise and arm rest ensure safety ...
... The Holten MaxiSafe 2010 Class II ... ergonomical working condition of comfort while ... efficiency and performance.,Refined operator, environment and ... both exhausted and recirculated air.,Bottom filters ...
... is designed for paramagnetic bead precipitation from ... PCR plates with no additional accessories. The ... a standard SBS 96-well microplate footprint. The ... guarantees easy and fast (as little as ...
... Minidizer is a personal desktop unit ideal for ... requirements. , Rotation speed set at 12 ... 80o C , Bottle capacity of four ... 15 ml conical ,plastic bottles , Consistent, ...
Biology Products: