Navigation Links
Researchers Identify Cause of Early Bird Sleep Disorder

A few rare people who consistently nod off early, then wake up wide-eyed much before dawn, can blame a newly-found mutant gene for their sleep troubles, Howard Hughes Medical Institute researchers announced today.

This odd "time-shift" trait -- called familial advanced sleep phase syndrome (FASPS) -- was studied in one affected family by neurologist Louis J. Ptacek, a Howard Hughes Medical Institute researcher, and Ying-Hui Fu, at the University of California, San Francisco. Their report appears in the March 31, 2005, issue of the journal Nature.

The sleep-shifting mutation they found is in "a gene that was not previously shown in mammals to be a circadian rhythm gene," Ptacek explained. It's not yet clear how the mutant gene works to shift people's sleep time, their circadian rhythm, he added. But follow-on experiments in fruit flies and mice yielded results that are intriguing.

When the mutant gene was inserted into the flies, for example, it did the opposite of what was seen in the human family: it lengthened circadian rhythm. Yet in genetically engineered mice, the same gene change made the mice early risers -- mimicking what was seen in humans with FASPS.

So, studies of all three organisms -- flies, mice and humans -- "will help us understand the similarities and differences" in how the gene works in different settings, in different genetic backgrounds, he said. Experiments can be done in mice and flies, with results applying to humans, while the studies of humans can inform what's being seen in the flies and mice.

In addition, "these results show that the gene is a central component of the mammalian circadian clock, and suggest that mammalian and fly clocks may have different regulatory mechanisms, despite the highly conserved nature of their individual components," the research team wrote in Nature. Such studies may help unravel some of the fundamental mysteries of how circadian rhythms are established and maintained in
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Identify Cause Early Bird Sleep Disorder

(Date:5/8/2015)... SAN JOSE, Calif. , May 8, 2015 ... human interface solutions, today announced that members of the executive ... J.P. Morgan 43rd Annual Technology, Media and Telecom Conference ... Westin Waterfront Hotel in Boston, MA ... Date: May 27, 2015 Time: 2:45pm ET Location: The New ...
(Date:4/27/2015)... 27, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... customers the first week of May, 2015 and will ... May. Gino Pereira , Chief ... the company as Wocket® enters the consumer market. We ...
(Date:4/17/2015)... BURNABY, Canada , April 17, 2015 /PRNewswire/ ... projects, growing security concerns, and technological advancement to ... Arabia until 2020   ... " Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric ... is projected to register growth at CAGR ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... American Association for Cancer Research congratulates 12 of its members ... among the 65 new members and five foreign associates. ... health and medicine, the award recognizes individuals who have demonstrated ... of health and medicine. "This is a great ...
... National Institute of Standards and Technology (NIST) may breathe ... technique for cell biology. The paper,* appearing this week ... improved hardware and better signal processing, a powerful form ... maps of the contents of cells without damaging them. ...
... October 14, 2010 A team of biomedical engineers from ... awarded a $6.25 million dollar, five-year Multi University Research Initiative ... the effects of blast waves on the neural circuitry of ... the use of improvised explosive devices (IEDs), blast-induced traumatic brain ...
Cached Biology News:The AACR congratulates its members elected to the Institute of Medicine 2Faster CARS, less damage: NIST chemical microscopy shows potential for cell diagnostics 2Columbia engineer part of team to receive $6.2 million DOD grant for blast research 2
(Date:5/20/2015)... May 19, 2015 Research and Markets ... "Global Cell Therapy Market Outlook 2020 " ... therapy in tissue and regenerative medicine is expected to ... options which could help in the growth of deregulated ... but they are unable to form new tissue or ...
(Date:5/20/2015)... The global genotyping market is expected to grow ... of 2015 to 2020 to reach $17.0billion in 2020. ... and development process and to provide personalized therapy, factors ... investments by key manufacturers to offer advanced and innovative ... Browse 113 market data tables & 37 figures spread ...
(Date:5/20/2015)... Agricultural firm H.J. Baker & Bro., Inc. today ... Since the purchase of Tiger Industries and Tiger-Sunbelt ... H.J. Baker has leveraged the innovation of the Tiger-Sul ... of product offerings and solutions expertise. The deal brought ... of Tiger-Sul, transforming the company into a leading enterprise ...
(Date:5/20/2015)... , May 20, 2015  Haemonetics Corporation (NYSE: ... President & CEO, will present at The Jefferies 2015 ... on June 1 st , 2015 at 8:30am ... Mr. Concannon,s presentation live via webcast at: ... (NYSE: HAE ) is a global healthcare company ...
Breaking Biology Technology:Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3
... in third quarter 2008; up 40% year-to-date , ... goodwill impairment charge , , ... Inc. (Nasdaq: ENCO ) , a full service ... countries for many of the world,s leading pharmaceutical and ...
... this years, most unique must-have gift , ... New York, NY(PRWEB) November ... from the customers, DNA, launch DNA Mini Portraits™, a more affordable line ... DNA Minis are the most personal and unique gifting solution for this ...
... Zounds Hearing, a unique manufacturing,and retail company ... point and professional service, announces the introduction of,assistive ... all who are hard of,hearing. The various devices ... Hearing,Centers retail locations effective November 24, 2008. ...
Cached Biology Technology:Encorium Reports Third Quarter 2008 Financial Results 2Encorium Reports Third Quarter 2008 Financial Results 3Encorium Reports Third Quarter 2008 Financial Results 4Encorium Reports Third Quarter 2008 Financial Results 5Encorium Reports Third Quarter 2008 Financial Results 6Encorium Reports Third Quarter 2008 Financial Results 7Encorium Reports Third Quarter 2008 Financial Results 8Encorium Reports Third Quarter 2008 Financial Results 9DNA 11, Creators of DNA Art, Introduces a More Affordable Line of Custom Portraits for this Year's Gift Giving Season 2Zounds Offers the Gift of Hearing This Holiday Season With a Range of New Products 2