Navigation Links
Researchers Identify Cause of Early Bird Sleep Disorder

A few rare people who consistently nod off early, then wake up wide-eyed much before dawn, can blame a newly-found mutant gene for their sleep troubles, Howard Hughes Medical Institute researchers announced today.

This odd "time-shift" trait -- called familial advanced sleep phase syndrome (FASPS) -- was studied in one affected family by neurologist Louis J. Ptacek, a Howard Hughes Medical Institute researcher, and Ying-Hui Fu, at the University of California, San Francisco. Their report appears in the March 31, 2005, issue of the journal Nature.

The sleep-shifting mutation they found is in "a gene that was not previously shown in mammals to be a circadian rhythm gene," Ptacek explained. It's not yet clear how the mutant gene works to shift people's sleep time, their circadian rhythm, he added. But follow-on experiments in fruit flies and mice yielded results that are intriguing.

When the mutant gene was inserted into the flies, for example, it did the opposite of what was seen in the human family: it lengthened circadian rhythm. Yet in genetically engineered mice, the same gene change made the mice early risers -- mimicking what was seen in humans with FASPS.

So, studies of all three organisms -- flies, mice and humans -- "will help us understand the similarities and differences" in how the gene works in different settings, in different genetic backgrounds, he said. Experiments can be done in mice and flies, with results applying to humans, while the studies of humans can inform what's being seen in the flies and mice.

In addition, "these results show that the gene is a central component of the mammalian circadian clock, and suggest that mammalian and fly clocks may have different regulatory mechanisms, despite the highly conserved nature of their individual components," the research team wrote in Nature. Such studies may help unravel some of the fundamental mysteries of how circadian rhythms are established and maintained in
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Identify Cause Early Bird Sleep Disorder

(Date:11/7/2014)... , November 6, 2014 Leading ... for better mobile security revolutionizing online transactions.  Companies in focus ... Holdings Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... ), eBay Inc. (NASDAQ: EBAY ) and MasterCard ... NXTD and NXTDW), a biometric authentication company focused on ...
(Date:11/5/2014)... in the UTSA College of Sciences, is one ... receive a two-year $300,00 National Science Foundation (NSF) ... funding supports President Obama,s BRAIN Initiative, a federal ... that will demystify complex brain processes. , ... broken into the interactions of multiple components, each ...
(Date:11/4/2014)... – Temple University School of Medicine announced today ... an initiative funded by the Bill & Melinda ... of Obstetrics, Gynecology and Reproductive Sciences; and Vice ... University School of Medicine will pursue an innovative ... Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2
... Researchers at Polytechnic Institute of New York University ... the smallest single virus particles in solution, an advance ... setting and shrink test result wait times from weeks ... applied physics and member of the Othmer-Jacobs Department of ...
... an array of essential functions, including cell signaling, communication ... of cells. They are critical targets for drug delivery ... biomarkers early warning beacons announcing the pre-symptomatic presence ... the binding properties of membrane proteins is essential, detailed ...
... people can drop pounds quickly in the early phases of ... to keep the weight off in the long term. ... long-term weight loss even more challenging. A new study ... to weight loss in the short term are not effective ...
Cached Biology News:By detecting smallest virus, researchers open possibilities for early disease detection 2By detecting smallest virus, researchers open possibilities for early disease detection 3A new look at proteins in living cells 2A new look at proteins in living cells 3A new look at proteins in living cells 4Is long-term weight loss possible after menopause? 2Is long-term weight loss possible after menopause? 3
(Date:11/21/2014)... The report, "Synthetic Biology ... Cloning kits), Technology (Bioinformatics, Nanotechnology, Gene Synthesis, ... Bioremediation) - Global Forecast to 2018", analyses ... opportunities, and challenges. , Browse 99 market ... 185 pages and in-depth TOC of the ...
(Date:11/21/2014)... Arkansas (PRWEB) November 20, 2014 ... Pinnacle Ozone Solutions, LLC (Pinnacle), and PCI, Inc., ... announced that they have been selected to provide ... of Fayetteville, Arkansas Paul R. Noland Wastewater Treatment. ... BlueInGreen’s patented HyDOZ® gas dissolution technology, ...
(Date:11/21/2014)... Texas (PRWEB) November 21, 2014 ... Sodium Ferrocyanide Industry” is a professional and in-depth ... provides Sodium ferrocyanide information, like its definition, ... as industry overview. This report covers the international ... as global (such as the US, Europe, Asia, ...
(Date:11/21/2014)... , Nov. 20, 2014 Polaris ... been dosed in its Phase 1 trial of ... for the treatment of malignant pleural mesothelioma (MPM) ... is conducting clinical trials on ADI-PEG 20, both ... for the treatment of several other indications, including ...
Breaking Biology Technology:Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2
... Advantages in Efficacy Will Drive Prescription Rates, According ... to a New Report ... Decision Resources, one of the,world,s leading research and advisory ... its approval in early 2009,Centocor/Janssen-Cilag,s ustekinumab will become the ...
... FRANCISCO, Feb. 13 BioSpace, the world,s leading,online ... company, hosted,over 1,000 biotechnology and pharmaceutical job candidates ... on Monday February 4, 2008., The BioSpace ... biotechnology,pharmaceutical, medical device, and diagnostics career candidates from,around ...
... antibody to be presented at AACR ... Special Conference on Cancer Stem Cells -, TORONTO, Feb. ... discovering and developing the next wave of,antibody therapeutics, today announced ... stem cell antibody will be,presented at the AACR Special Conference ...
Cached Biology Technology:Centocor/Janssen-Cilag's Ustekinumab Will Become the Gold Standard for Psoriasis By 2011 2BioSpace Career Fair in San Francisco Welcomes Over 1,000 Bioscience Professionals 2ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 2ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 3ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 4
... peptide derived from the internal region of ... Specific for the internal region of the ... the target band at ~590 kDa. ... media from primary tracheobranchial epithelial cultures and ...
Lipid-rich bovine serum albumin for cell culture. It is chromatographically purified and has an IgG content 1.0% (w/w)....
Prepared with distilled water. Yeast extract solution is autolyzed at 150 g/L....
Request Info...
Biology Products: