Navigation Links
Research advances quest for HIV-1 vaccine

Scientists have uncovered new information that may help guide design of vaccines for HIV-1, the virus that causes AIDS. A new detailed structural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far. The research is published in the February issue of Immunity.

Vaccination has been a successful strategy for protecting humans from many potentially harmful viruses. However, designing a suitable vaccine for HIV-1 has been a highly challenging and thus far unsuccessful endeavor. HIV-1 is enormously variable and it has been difficult to isolate antibodies that will recognize the many different strains of the virus. The antibody 4E10 was derived from HIV-1 infected patients by Dr. Hermann Katinger in Vienna and is the broadest acting neutralizing antibody against HIV-1 that is currently known. This antibody recognizes a protein called gp41 that is found on the surface of the virus. The gp41 protein is thought to play a key role in mediating entry of HIV-1 into human cells.

A research group led by Drs. Dennis R. Burton and Ian A. Wilson from The Scripps Research Institute in La Jolla, California performed a study examining the detailed molecular structure of the complex formed when 4E10 binds to gp41 and determining how interaction of 4E10 with gp41 influences the virus.

X-ray crystallography was used to determine the structure of the complex formed by association of 4E10 with a peptide fragment that is identical to the section of gp41 that the antibody recognizes. The researchers identified the specific amino acids on gp41 that 4E10 interacts with and the 3D structure adopted by these amino acids. These study results suggest that 4E10 interacts with gp41 at a conserved region very close to the surface of the virus and they reveal some special characteristics of 4E10 that make it unusually
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research on Worms Yields Clues on Aging
6. Researchers reveal the infectious impact of salmon farms on wild salmon
7. Researchers identify target for cancer drugs
8. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
9. Researchers discover molecule that causes secondary stroke
10. Researchers find missing genes of ancient organism
11. Researchers trace evolution to relatively simple genetic changes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Research advances quest for HIV vaccine

(Date:7/27/2015)...   Zynx Health ™, the market leader ... today announced that its ZynxCarebook ™ mobile ... smartphones and tablets. With this expansion, care team ... ZynxCarebook to securely exchange messages and share assessments ... to other care settings, and improve clinical outcomes ...
(Date:7/21/2015)... Passwords have proven futile for securing ... U.S. Office of Personnel Management breach. Biometric authentication ... but developers and end-users are concerned about how ... Biometrics-as-a-Service provider HYPR Corp. announced today the general ... party integration. A video overview ...
(Date:7/9/2015)... , July 07, 2015 ... announced the addition of the "Biometrics for ... Forecasts 2015-2020" report to their offering. ... major contributor to this growth and the forecast ... billion in revenue for companies involved in delivering ...
Breaking Biology News(10 mins):Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... the genetics of so many organisms that have different ... gathering full sets of genetic information from organisms rapidly ... to the "trees" of each individual case and detail. ... Science by David Wake, Marvalee Wake and Chelsea ...
... Mouse models are yielding important clues about the nature ... in 110 children in the U.S.[1] In labs at ... studying strains of mice that inherently mimic the repetitive ... Georgianna Gould, Ph.D., research assistant professor of physiology in ...
... ESCEO will be staging the European Congress on ... in Europe, to be held in Valencia, Spain ... of March 7, 2011 fast approaches, registrants are ... 1st IOF-ESCEO Pre-Clinical Symposium (from March 22-23, 2011). ...
Cached Biology News:Serotonin plays role in many autism cases, studies confirm 28 special sessions at European Congress on Osteoporosis and Osteoarthritis in Valencia 2
(Date:7/30/2015)... , July 30, 2015 Ascendis ... company that applies its innovative TransCon technology to ... top-line results from a six-month Phase 2 study ... TransCon Growth Hormone in 53 treatment-naïve, pre-pubertal children ... "We are extremely pleased with the top-line results ...
(Date:7/30/2015)... , July 30, 2015  Discovery Laboratories, ... it has received the second $1.0M tranche under ... Research (SBIR) grant valued at up to $3.0 ... aerosolized KL4 surfactant as a potential medical countermeasure ...  Discovery Labs was awarded an initial $1.0 million ...
(Date:7/30/2015)... ... July 30, 2015 , ... GEA's ... designed for continuous operation up to 1500 bar. The sanitary design gauge of ... preventing toxic contamination. , The Pony™ NS2006L homogenizer is an ideal solution for ...
(Date:7/29/2015)... -- Sanofi, un leader mondial et ... le premier semestre 2015. Le Directeur Général ... Visionner l,interview vidéo et lire la transcription :  ... sommaire de l,interview :  - Résultats ... - Diabète - Praluent ...
Breaking Biology Technology:Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... implementation of quality systems in product design ... ... assay, COLUMBIA, Md., Oct. 1 Cylex has ... 13485:2003 certification,includes compliance with the Canadian Medical Devices Conformity ...
... Sept. 30 Synthetech, Inc. (OTC,Bulletin Board: NZYM) ... Director of Manufacturing effective on October 1, 2008. ... to Synthetech. Dr. Farkas,has over 13 years, experience ... previous positions in manufacturing and supply chain,management at ...
... Presidential Support for Faster Registration ... of Modern Medicines in Ukraine -, ... of MaxWell Biocorporation, LLC, and Dr. Peter M. Leitner, President ... honor,Ukrainian President Victor Yushchenko., (Logo: http://www.newscom.com/cgi-bin/prnh/20080624/NETU078LOGO ), ...
Cached Biology Technology:Cylex(TM) Receives ISO 13485:2003 and 9001:2000 Quality Certifications 2Synthetech Announces New Director of Manufacturing 2Ukrainian President Yushchenko: Pharmaceuticals 'Very Important' 2
... DTT White solid.. PACKAGED UNDER INERT ... so reaction is "driven" to completion. A protective ... surfactant found in many other preparations. Blocks the ... ≥97% by titration. Contaminants: Heavy metals: ...
... virus of Japan, also named Sendai virus) ... transfection of molecules by means of membrane ... (RNAi), Protein, Oligo, cDNA, Antibodies, Vector, and ... GenomONE-Neo EX has a high fusing capability ...
... Whole Genome ChIP-on-chip Microarray is specifically ... (S. cerevisiae) DNA binding proteins by ... DNA microarrays. This set delivers robust ... greater true binding events and fewer ...
... highest precision, more user-friendliness and absolute reliability ... the definition of the Mastercycler ep system. ... research has been developing dynamically. The same ... Systems. To keep pace with these ...
Biology Products: